{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:59:52Z","timestamp":1756994392692},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1906,5,25]]},"abstract":"<jats:p>From the experiments detailed in this paper it may be concluded that Amanita phalloides contains besides phallin, or the h\u00e6molytic principle of Kobert, another body of toxic nature. Phallin is thermolabile, and is destroyed by the action of pepsin and pancreatin. The other toxic body is thermostable and is resistant to pepsin and pancreatin. The two substances, moreover, possess different toxophoric and haptophoric groups, since an antiserum produced by the immunization of animals to the thermostable body has no neutralizing effects upon phallin.<\/jats:p>\n               <jats:p>The thermolable body, phallin, produces the subcutaneous \u0153dema and h\u00e6moglobinuria, and, in virtue of its blood-laking properties, the pigmentation of the spleen. The thermostable body produces h\u00e6morrhage and necrosis, and the fatty degeneration of the parenchymatous organs. The two bodies exist side by side in watery extracts of the fungus, but they cannot be considered as two constituents of a single poison exerting a variety of effects. To the h\u00e6molysin the name phallin has already been given by its discoverer, Kobert. For the thermostable substance described now for the first time, the name Amanito-toxin is proposed provisionally.<\/jats:p>","DOI":"10.1084\/jem.8.3.437","type":"journal-article","created":{"date-parts":[[2004,6,17]],"date-time":"2004-06-17T22:31:16Z","timestamp":1087511476000},"page":"437-450","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["THE TOXICOLOGICAL CONSTITUTION OF AMANITA PHALLOIDES"],"prefix":"10.1084","volume":"8","author":[{"given":"William W.","family":"Ford","sequence":"first","affiliation":[{"name":"From the Bacteriological Laboratory, Johns Hopkins University."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1906,5,25]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/8\/3\/437\/1184149\/437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/8\/3\/437\/1184149\/437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:59:23Z","timestamp":1601733563000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/8\/3\/437\/4940\/THE-TOXICOLOGICAL-CONSTITUTION-OF-AMANITA"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1906,5,25]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1906,5,25]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.8.3.437","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1906,5,25]]}}}