{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:18:40Z","timestamp":1756995520701},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1945,8,1]]},"abstract":"<jats:p>1. Type-specific antibodies were demonstrated by the indirect bacteriostatic test in sera from human adults convalescing from group A streptococcal infection of the upper respiratory tract. The time of appearance of the antibodies varied from 3 to 5 weeks; and they persisted in 2 patients for at least 37 weeks after the onset of the infection.<\/jats:p>\n               <jats:p>2. The specificity of the antibody response in one serum was tested with strains of 7 heterologous types; in another, with 6; and in the third, with 2; but in no instance were cross-reactions observed. Moreover, each convalescent serum showed approximately equal bacteriostasis for 7 different strains of the same type as that which caused the infection.<\/jats:p>\n               <jats:p>3. The antibodies were specifically absorbed from the serum by homologous heat-killed streptococci, but not significantly by strains of heterologous types.<\/jats:p>\n               <jats:p>4. The specific M antigen of the streptococcal cell with its respective antibody, and not the T substance, appeared to be concerned in the reaction.<\/jats:p>\n               <jats:p>5. In spite of numerous technical difficulties inherent in the method, this bacteriostatic test provides a useful procedure for studying type-specific immunity in streptococcal infections.<\/jats:p>","DOI":"10.1084\/jem.82.2.93","type":"journal-article","created":{"date-parts":[[2004,6,21]],"date-time":"2004-06-21T23:43:35Z","timestamp":1087861415000},"page":"93-106","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["BACTERIOSTATIC EFFECT OF HUMAN SERA ON GROUP A STREPTOCOCCI"],"prefix":"10.1084","volume":"82","author":[{"given":"Sidney","family":"Rothbard","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1945,8,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/82\/2\/93\/1141380\/93.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/82\/2\/93\/1141380\/93.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T08:27:30Z","timestamp":1601713650000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/82\/2\/93\/4886\/BACTERIOSTATIC-EFFECT-OF-HUMAN-SERA-ON-GROUP-A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1945,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1945,8,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.82.2.93","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1945,8,1]]}}}