{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:10:30Z","timestamp":1758280230430},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1948,1,1]]},"abstract":"<jats:p>After disintegration by sonic vibrations the contents of the hemolytic streptococcus can be separated by differential centrifugation into three fractions: an insoluble residue, cytoplasmic particles, and a solution of proteins of smaller unit size.<\/jats:p>\n               <jats:p>The residue (R) presumably comprises the cell walls of the bacteria and contains the type-specific M protein. The cytoplasmic particles (CP) contain some lipoid, the group-specific carbohydrate, and nucleoprotein of the ribose type. The supernate fraction (S) contains two components, presumably protein, at least one of which is part of a dissociable nucleoprotein of the desoxyribose type.<\/jats:p>\n               <jats:p>Both CP and S precipitate and fix complement with antistreptococcal sera. Both give rise to antibodies on injection into rabbits. Both are of broad reactivity. CP and S can be shown to be serologically distinct by several means, including cross-absorption tests.<\/jats:p>\n               <jats:p>On continued disintegration of the organism an inverse relation is noted between the yield of R and that of CP, whereas the yield of S is constant.<\/jats:p>\n               <jats:p>A theory as to the structure of the streptococcal cell is offered in terms of the data presented.<\/jats:p>","DOI":"10.1084\/jem.87.1.41","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"41-56","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER"],"prefix":"10.1084","volume":"87","author":[{"given":"T. N.","family":"Harris","sequence":"first","affiliation":[{"name":"From The Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), the Children's Seashore House for Invalid Children, Atlantic City, and the Philadelphia General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1948,1,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/87\/1\/41\/1183711\/41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/87\/1\/41\/1183711\/41.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:49:08Z","timestamp":1601732948000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/87\/1\/41\/5122\/STUDIES-IN-THE-RELATION-OF-THE-HEMOLYTIC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1948,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1948,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.87.1.41","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1948,1,1]]}}}