{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:41:53Z","timestamp":1756993313012},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1948,1,1]]},"abstract":"<jats:p>Complement-fixing antibodies to the cytoplasmic particles (CP) and to the S fraction of streptococcal nucleoproteins are present in normal human sera, the range of concentrations varying among the age groups.<\/jats:p>\n               <jats:p>The titer of these antibodies rises between the first half-week and the 3rd week of scarlet fever, in more than 80 per cent of the cases. The titers then remain elevated for at least 4 months.<\/jats:p>\n               <jats:p>In children, 91 per cent of the normal sera examined showed anti-CP titers up to 32; 87 per cent of sera in active rheumatic disease had titers above this level. Corresponding data with S fell in the same range of percentage distribution.<\/jats:p>\n               <jats:p>Anti-CP and anti-S titers remained elevated long after the rheumatic process had reached quiescence. No correlation of serologic titer with the degree of clinical activity was found in the case of either antibody.<\/jats:p>","DOI":"10.1084\/jem.87.1.57","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"57-70","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["STUDIES IN THE RELATION OF THE HEMOLYTIC STREPTOCOCCUS TO RHEUMATIC FEVER"],"prefix":"10.1084","volume":"87","author":[{"given":"T. N.","family":"Harris","sequence":"first","affiliation":[{"name":"From The Children's Hospital of Philadelphia (Department of Pediatrics, School of Medicine, University of Pennsylvania), the Children's Seashore House for Invalid Children, Atlantic City, and the Philadelphia General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1948,1,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/87\/1\/57\/1183761\/57.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/87\/1\/57\/1183761\/57.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:50:31Z","timestamp":1601733031000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/87\/1\/57\/5112\/STUDIES-IN-THE-RELATION-OF-THE-HEMOLYTIC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1948,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1948,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.87.1.57","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1948,1,1]]}}}