{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T20:33:16Z","timestamp":1721248396473},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1948,9,1]]},"abstract":"<jats:p>The relationship between the fever of acute infection and that following injection of bacterial pyrogen was studied by administering pyrogens to animals convalescent from acute infections.<\/jats:p>\n               <jats:p>Rabbits surviving dermal pneumococcal infections or peritonitis due to Escherichia coli were given intravenous injections of typhoid or E. coli vaccine. They showed no evidence of tolerance to the fever-promoting effect of these pyrogenic materials.<\/jats:p>\n               <jats:p>Tolerance did develop in infected animals given daily pyrogen injections during the course of the infection.<\/jats:p>\n               <jats:p>Certain previous observations upon the ability of rabbits to develop tolerance to pyrogens, the broad nature of the tolerance, and its duration were confirmed.<\/jats:p>\n               <jats:p>It is concluded that the pyrogen produced by certain bacteria plays little or no ro\u0302le in the production of the fever of infection.<\/jats:p>\n               <jats:p>These findings are compatible with the hypothesis that there is a common factor, perhaps a product of cell injury, underlying the fever accompanying diseases of various types.<\/jats:p>","DOI":"10.1084\/jem.88.3.267","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"267-278","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["OBSERVATIONS ON THE FEVER CAUSED BY BACTERIAL PYROGENS"],"prefix":"10.1084","volume":"88","author":[{"suffix":"Jr.","given":"Ivan L.","family":"Bennett","sequence":"first","affiliation":[{"name":"From the Naval Medical Research Institute, Bethesda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1948,9,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/88\/3\/267\/1183819\/267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/88\/3\/267\/1183819\/267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:51:57Z","timestamp":1601733117000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/88\/3\/267\/5167\/OBSERVATIONS-ON-THE-FEVER-CAUSED-BY-BACTERIAL"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1948,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1948,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.88.3.267","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1948,9,1]]}}}