{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:29:18Z","timestamp":1772782158181,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1949,1,1]]},"abstract":"<jats:p>The intravenous injection of one large dose of serum into rabbits caused a variety of changes of considerable complexity.<\/jats:p>\n               <jats:p>1. There was an immediate proliferation of mesenchymal cells, including plasma cells, particularly in heart, lungs, and spleen.<\/jats:p>\n               <jats:p>2. The signs of serum disease developed only at the time of abundant antibody formation, before significant quantities of antibody were laid down in the vascular connective tissue.<\/jats:p>\n               <jats:p>3. Allergic arteritis, marked glomerular nephritis, myocardial necrosis, and Aschoff body-like structures were seen only after hypersensitivity had developed. It appears that most, if not all, of these pathological alterations were true Arthus phenomena.<\/jats:p>\n               <jats:p>4. There were at least two distinct varieties of allergic arteritis and glomerular nephritis, namely a proliferative one, following the first injection, and a a necrotizing one, seen only after 2 injections. It appears that the first was a subacute Arthus phenomenon, while the latter was an acute Arthus phenomenon superimposed on a subacute one. The subacute experimental glomerular nephritis resembled the intracapillary glomerulonephritis in man, while the acute variety was like human extracapillary glomerular nephritis.<\/jats:p>","DOI":"10.1084\/jem.89.1.23","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"23-36","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["EXPERIMENTAL SERUM DISEASE"],"prefix":"10.1084","volume":"89","author":[{"given":"W. E.","family":"Ehrich","sequence":"first","affiliation":[{"name":"From the Graduate School of Medicine of the University of Pennsylvania, the Wyeth Institute of Applied Biochemistry, and the Philadelphia General Hospital, Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Seifter","sequence":"additional","affiliation":[{"name":"From the Graduate School of Medicine of the University of Pennsylvania, the Wyeth Institute of Applied Biochemistry, and the Philadelphia General Hospital, Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Forman","sequence":"additional","affiliation":[{"name":"From the Graduate School of Medicine of the University of Pennsylvania, the Wyeth Institute of Applied Biochemistry, and the Philadelphia General Hospital, Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1949,1,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/89\/1\/23\/1183931\/23.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/89\/1\/23\/1183931\/23.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:55:15Z","timestamp":1601733315000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/89\/1\/23\/5209\/EXPERIMENTAL-SERUM-DISEASE-A-PATHOGENETIC-STUDY"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1949,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1949,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.89.1.23","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1949,1,1]]}}}