{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:12:56Z","timestamp":1756995176111},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1949,3,1]]},"abstract":"<jats:p>The total plasmin and the trypsin inhibitor were titrated separately in samples of serum taken at weekly intervals from three different groups of scarlet fever patients: (a) those who did not develop any complications, (b) those who developed purulent complications, and (c) those who developed rheumatic fever.<\/jats:p>\n               <jats:p>When these determinations were plotted, it was found that the resulting curves showed characteristic patterns for each of the diseases investigated.<\/jats:p>\n               <jats:p>The uncomplicated cases had plasmin curves which were considerably higher on the charts than the inhibitor curves.<\/jats:p>\n               <jats:p>The septic cases had plasmin and inhibitor curves which were closer together on the charts.<\/jats:p>\n               <jats:p>The rheumatic cases had plasmin and inhibitor curves which were close together and which crossed at the time of rheumatic activity so that the inhibitor curve reached a higher level than the plasmin curve.<\/jats:p>","DOI":"10.1084\/jem.89.3.309","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"309-324","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["QUANTITATIVE STUDIES ON THE TOTAL PLASMIN AND THE TRYPSIN INHIBITOR OF HUMAN BLOOD SERUM"],"prefix":"10.1084","volume":"89","author":[{"given":"Edgar W.","family":"Todd","sequence":"first","affiliation":[{"name":"From the Hospital of The Rockefeller Institute for Medical Research, New York, and The Rheumatic Fever Research Institute, Northwestern University, Chicago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1949,3,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/89\/3\/309\/1184021\/309.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/89\/3\/309\/1184021\/309.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T13:56:50Z","timestamp":1601733410000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/89\/3\/309\/5226\/QUANTITATIVE-STUDIES-ON-THE-TOTAL-PLASMIN-AND-THE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1949,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1949,3,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.89.3.309","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1949,3,1]]}}}