{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:01:45Z","timestamp":1757700105398},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1952,12,1]]},"abstract":"<jats:p>Intravenous injection of thorotrast or trypan blue rendered rabbits susceptible to the production of bilateral cortical necrosis of the kidneys by a single intravenous injection of small amounts of meningococcal or Serratia marcescens toxin. This reaction was not produced when thorotrast or trypan blue were injected after toxin had been given.<\/jats:p>\n               <jats:p>A single intradermal injection of toxin produced hemorrhagic skin lesions resembling the local Shwartzman reaction in rabbits given thorotrast 6 hours previously. These animals also developed bilateral cortical necrosis of the kidneys. When the order of injection was reversed, and thorotrast given after toxin, neither skin nor kidney lesions occurred.<\/jats:p>\n               <jats:p>The skin and kidney lesions in thorotrast-treated rabbits were, like the local and generalized Shwartzman reactions, completely prevented by treatment with nitrogen mustard, in doses sufficient to produce polymorphonuclear leukopenia.<\/jats:p>\n               <jats:p>The significance of these reactions, and their relationship to the previously described response to toxin in cortisone-treated rabbits, are discussed.<\/jats:p>","DOI":"10.1084\/jem.96.6.625","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T18:35:50Z","timestamp":1087929350000},"page":"625-641","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":84,"title":["STUDIES ON THE GENERALIZED SHWARTZMAN REACTION"],"prefix":"10.1084","volume":"96","author":[{"given":"Robert A.","family":"Good","sequence":"first","affiliation":[{"name":"From the Heart Hospital Research Laboratories and the Department of Pediatrics, University of Minnesota Medical School, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Thomas","sequence":"additional","affiliation":[{"name":"From the Heart Hospital Research Laboratories and the Department of Pediatrics, University of Minnesota Medical School, Minneapolis"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1952,12,1]]},"container-title":["Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/96\/6\/625\/1185055\/625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jem\/article-pdf\/96\/6\/625\/1185055\/625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T14:16:11Z","timestamp":1601734571000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/96\/6\/625\/10657\/STUDIES-ON-THE-GENERALIZED-SHWARTZMAN-REACTION-II"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1952,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1952,12,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.96.6.625","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1952,12,1]]}}}