{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:16:58Z","timestamp":1762100218190},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,11,1]]},"abstract":"<jats:p>Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet factor 3. Since platelet factor 3 can be demonstrated in platelet-poor plasma as well as platelet-rich plasma after endotoxin injection, it seems likely that an actual transfer of factor 3 from platelets to plasma occurs and that this activity is then rapidly inactivated or cleared from the blood stream.<\/jats:p>","DOI":"10.1084\/jem.116.5.619","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"619-633","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":82,"title":["EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS"],"prefix":"10.1084","volume":"116","author":[{"given":"Herbert I.","family":"Horowitz","sequence":"first","affiliation":[{"name":"From the Department of Medicine, The New York Hospital-Cornell Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger M.","family":"Des Prez","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, The New York Hospital-Cornell Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward W.","family":"Hook","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, The New York Hospital-Cornell Medical Center, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1962,11,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/116\/5\/619\/1649625\/619.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/116\/5\/619\/1649625\/619.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:28:06Z","timestamp":1690226886000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/116\/5\/619\/3127\/EFFECTS-OF-BACTERIAL-ENDOTOXIN-ON-RABBIT-PLATELETS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1962,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.116.5.619","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1962,11,1]]}}}