{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:21:25Z","timestamp":1771374085071,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"3","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1965,9,1]]},"abstract":"<jats:p>Two strains of selectively inbred rats were demonstrated previously to have opposite genetic predisposition to develop hypertension from NaCl ingestion (1, 2), DOCA-NaCl (3), and unilateral renal artery compression without NaCl (3).<\/jats:p>\n               <jats:p>Using these same strains, similar disparate responses were elicited with two other models for inducing experimental hypertension, namely cortisone and adrenal regeneration.<\/jats:p>\n               <jats:p>On the basis of these experiences, it is proposed that the genetic substrate will be found to modify significantly the influence of all non-genetic factors considered to play a primary role in the etiology of experimental hypertension. Furthermore, it is suggested that similar genetic and non-genetic factors interact to produce hypertension in man. An hypothesis has been elaborated that is compatible with the experimental data and there is some clinical evidence to support this hypothesis.<\/jats:p>","DOI":"10.1084\/jem.122.3.533","type":"journal-article","created":{"date-parts":[[2004,6,22]],"date-time":"2004-06-22T20:51:07Z","timestamp":1087937467000},"page":"533-545","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["EFFECTS OF CHRONIC EXCESS SALT INGESTION"],"prefix":"10.1084","volume":"122","author":[{"given":"Lewis K.","family":"Dahl","sequence":"first","affiliation":[{"name":"From the Medical Research Center, Brookhaven National Laboratory, Upton, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Heine","sequence":"additional","affiliation":[{"name":"From the Medical Research Center, Brookhaven National Laboratory, Upton, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Tassinari","sequence":"additional","affiliation":[{"name":"From the Medical Research Center, Brookhaven National Laboratory, Upton, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1965,9,1]]},"container-title":["The Journal of Experimental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/122\/3\/533\/1650935\/533.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/122\/3\/533\/1650935\/533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T19:48:10Z","timestamp":1690228090000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/122\/3\/533\/3871\/EFFECTS-OF-CHRONIC-EXCESS-SALT-INGESTION-FURTHER"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1965,9,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.122.3.533","relation":{},"ISSN":["1540-9538","0022-1007"],"issn-type":[{"value":"1540-9538","type":"electronic"},{"value":"0022-1007","type":"print"}],"subject":[],"published":{"date-parts":[[1965,9,1]]}}}