{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T03:16:08Z","timestamp":1782011768334,"version":"3.54.5"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,2,1]]},"abstract":"<jats:p>Evidence is presented to support the contention that IgM demonstrable by surface immunofluorescent staining on H-2-activated T cells represents specifically adsorbed B-cell-derived alloantibody. T cells activated to H-2 determinants expressed surface IgM only when the progenitor cell populations contained B lymphocytes. IgM was not detected on T cells activated to determinants which fail to stimulate alloantibody production (e.g., M-locus determinants). In addition, IgM-negative H-2 activated T cells (derived from B-cell-depleted lymphoid cells), unlike M-locus-activated T cells, adsorbed IgM in a specific manner when incubated in vitro with \"early bleed\" antisera raised against the activating H-2 determinants.<\/jats:p>","DOI":"10.1084\/jem.143.2.444","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes."],"prefix":"10.1084","volume":"143","author":[{"given":"L","family":"Hudson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Sprent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1976,2,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/143\/2\/444\/1657286\/444.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/143\/2\/444\/1657286\/444.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T22:45:41Z","timestamp":1690238741000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/143\/2\/444\/21999\/Specific-adsorption-of-IgM-antibody-onto-H-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1976,2,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.143.2.444","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,2,1]]}}}