{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T01:58:22Z","timestamp":1744163902226},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,1,1]]},"abstract":"<jats:p>Immunization of BALB\/c mice with nuclease leads to the production of anti-nuclease antibodies bearing a set of cross-reactive idiotypes (Id) distinct from those produced by B10.D2 mice after similar immunization. In both strains, such immunization with nuclease also leads to the production of splenic T helper cells (TH), which provide nuclease-specific help in an in vitro plaque-forming cell response to nuclease-TNP. Pig anti-(BALB\/c antinuclease) anti-idiotypic antibodies (pig anti-BALB\/c Id) react only with TH of nuclease-primed BALB\/c and not with B10.D2 animals. After administration of pig anti-BALB\/c Id in complete Freund's adjuvant to BALB\/c and B10.D2 mice, Id-bearing nonantigen-binding molecules were induced in both strains. Such treatment also resulted in the induction of nuclease-specific splenic TH cells in both strains. BALB\/c TH cells induced by anti-Id, like the majority of nuclease-primed BALB\/c TH cells, bore BALB\/c Id, as shown by their functional elimination with anti-Id plus complement. B10.D2 TH cells induced by anti-Id, unlike TH cells from nuclease-primed B10.D2 mice, also bore BALB\/c idiotypic determinants by the same criterion. Thus, it appears that one can manipulate the expression of Id on serum immunoglobulins and on antigen-specific TH cells by administration of exogenous anti-Id reagents. These results have implications both for network interactions in the immune response and for the genetic basis of Igh-C linked Id expression.<\/jats:p>","DOI":"10.1084\/jem.155.1.190","type":"journal-article","created":{"date-parts":[[2004,6,23]],"date-time":"2004-06-23T21:00:50Z","timestamp":1088024450000},"page":"190-200","update-policy":"http:\/\/dx.doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Modification of T cell antinuclease idiotype expression by in vivo administration of anti-idiotype."],"prefix":"10.1084","volume":"155","author":[{"given":"G G","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P I","family":"Nadler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Hodes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Sachs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1982,1,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/155\/1\/190\/1662701\/190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/155\/1\/190\/1662701\/190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:29:02Z","timestamp":1690244942000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/155\/1\/190\/22895\/Modification-of-T-cell-antinuclease-idiotype"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.155.1.190","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1,1]]}}}