{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:38:45Z","timestamp":1784371125162,"version":"3.55.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,11,1]]},"abstract":"<jats:p>We have reported the identification of human gene MAGE-1, which directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes (CTL). We show here that CTL directed against this antigen, which was named MZ2-E, recognize a nonapeptide encoded by the third exon of gene MAGE-1. The CTL also recognize this peptide when it is presented by mouse cells transfected with an HLA-A1 gene, confirming the association of antigen MZ2-E with the HLA-A1 molecule. Other members of the MAGE gene family do not code for the same peptide, suggesting that only MAGE-1 produces the antigen recognized by the anti-MZ2-E CTL. Our results open the possibility of immunizing HLA-A1 patients whose tumor expresses MAGE-1 either with the antigenic peptide or with autologous antigen-presenting cells pulsed with the peptide.<\/jats:p>","DOI":"10.1084\/jem.176.5.1453","type":"journal-article","created":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T07:56:10Z","timestamp":1088063770000},"page":"1453-1457","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":486,"title":["A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E."],"prefix":"10.1084","volume":"176","author":[{"given":"C","family":"Traversari","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"van der Bruggen","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I F","family":"Luescher","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Lurquin","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Chomez","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Van Pel","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"De Plaen","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Amar-Costesec","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Boon","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Brussels Branch, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1992,11,1]]},"container-title":["The Journal of experimental medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/5\/1453\/1673719\/1453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jem\/article-pdf\/176\/5\/1453\/1673719\/1453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T04:47:30Z","timestamp":1690260450000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jem\/article\/176\/5\/1453\/58243\/A-nonapeptide-encoded-by-human-gene-MAGE-1-is"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,11,1]]}},"URL":"https:\/\/doi.org\/10.1084\/jem.176.5.1453","relation":{},"ISSN":["0022-1007","1540-9538"],"issn-type":[{"value":"0022-1007","type":"print"},{"value":"1540-9538","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11,1]]}}}