{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:45:18Z","timestamp":1770698718777,"version":"3.49.0"},"reference-count":30,"publisher":"Rockefeller University Press","issue":"12","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,6,15]]},"abstract":"<jats:p>Clonally distributed inhibitory receptors negatively regulate natural killer (NK) cell function via specific interactions with allelic forms of major histocompatibility complex (MHC) class I molecules. In the mouse, the Ly-49 family of inhibitory receptors is found not only on NK cells but also on a minor (NK1.1+) T cell subset. Using Ly-49 transgenic mice, we show here that the development of NK1.1+ T cells, in contrast to NK or conventional T cells, is impaired when their Ly-49 receptors engage self-MHC class I molecules. Impaired NK1.1+ T cell development in transgenic mice is associated with a failure to select the appropriate CD1-reactive T cell receptor repertoire. In normal mice, NK1.1+ T cell maturation is accompanied by extinction of Ly-49 receptor expression. Collectively, our data imply that developmentally regulated extinction of inhibitory MHC-specific receptors is required for normal NK1.1+ T cell maturation and selection.<\/jats:p>","DOI":"10.1084\/jem.187.12.2109","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:49:30Z","timestamp":1027702170000},"page":"2109-2114","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Developmentally Regulated Extinction of Ly-49 Receptor Expression Permits Maturation and Selection of NK1.1+ T Cells"],"prefix":"10.1084","volume":"187","author":[{"given":"H.","family":"Robson MacDonald","sequence":"first","affiliation":[{"name":"From the Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland"}]},{"given":"Rosemary K.","family":"Lees","sequence":"additional","affiliation":[{"name":"From the Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland"}]},{"given":"Werner","family":"Held","sequence":"additional","affiliation":[{"name":"From the Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland"}]}],"member":"291","published-online":{"date-parts":[[1998,6,15]]},"reference":[{"key":"2023072507490477900_B1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1084\/jem.182.3.633","article-title":"NK1.1+ T cell receptor \u03b1\u03b2+cells: new clues to their origin, specificity and function","volume":"182","author":"MacDonald","year":"1995","journal-title":"J Exp Med"},{"key":"2023072507490477900_B2","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4049\/jimmunol.155.3.1020","article-title":"Natural T cells. 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