{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:07:19Z","timestamp":1770412039877,"version":"3.49.0"},"reference-count":37,"publisher":"Rockefeller University Press","issue":"13","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,12,24]]},"abstract":"<jats:p>Identification of a thymus-seeding progenitor originating from human bone marrow (BM) constitutes a key milestone in understanding the mechanisms of T cell development and provides new potential for correcting T cell deficiencies. We report the characterization of a novel lymphoid-restricted subset, which is part of the lineage-negative CD34+CD10+ progenitor population and which is distinct from B cell\u2013committed precursors (in view of the absence of CD24 expression). We demonstrate that these Lin\u2212CD34+CD10+CD24\u2212 progenitors have a very low myeloid potential but can generate B, T, and natural killer lymphocytes and coexpress recombination activating gene 1, terminal deoxynucleotide transferase, PAX5, interleukin 7 receptor \u03b1, and CD3\u03b5. These progenitors are present in the cord blood and in the BM but can also be found in the blood throughout life. Moreover, they belong to the most immature thymocyte population. Collectively, these findings unravel the existence of a postnatal lymphoid-polarized population that is capable of migrating from the BM to the thymus.<\/jats:p>","DOI":"10.1084\/jem.20071003","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T01:35:19Z","timestamp":1197336919000},"page":"3085-3093","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":100,"title":["A human postnatal lymphoid progenitor capable of circulating and seeding the thymus"],"prefix":"10.1084","volume":"204","author":[{"given":"Emmanuelle M.","family":"Six","sequence":"first","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"}]},{"given":"Delphine","family":"Bonhomme","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"}]},{"given":"Marta","family":"Monteiro","sequence":"additional","affiliation":[{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"3INSERM, U591, 75015 Paris, France"}]},{"given":"Kheira","family":"Beldjord","sequence":"additional","affiliation":[{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"4Laboratoire d'He\u0301matologie"},{"name":"7INSERM, EMI0210, 75015 Paris, France"}]},{"given":"Monika","family":"Jurkowska","sequence":"additional","affiliation":[{"name":"4Laboratoire d'He\u0301matologie"}]},{"given":"Corinne","family":"Cordier-Garcia","sequence":"additional","affiliation":[{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"}]},{"given":"Alexandrine","family":"Garrigue","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"5De\u0301partement de Biothe\u0301rapie,"}]},{"given":"Liliane","family":"Dal Cortivo","sequence":"additional","affiliation":[{"name":"5De\u0301partement de Biothe\u0301rapie,"}]},{"given":"Benedita","family":"Rocha","sequence":"additional","affiliation":[{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"3INSERM, U591, 75015 Paris, France"}]},{"given":"Alain","family":"Fischer","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"6Service d'Immunologie et d'He\u0301matologie Pe\u0301diatrique, Hopital Necker-Enfants Malades, Assistance Publique\u2013Ho\u0302pitaux de Paris, 75015 Paris, France"}]},{"given":"Marina","family":"Cavazzana-Calvo","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"},{"name":"5De\u0301partement de Biothe\u0301rapie,"}]},{"given":"Isabelle","family":"Andre\u0301-Schmutz","sequence":"additional","affiliation":[{"name":"1Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (INSERM), U768, 75015 Paris, France"},{"name":"2Faculte\u0301 de Me\u0301decine Rene\u0301 Descartes, Institut Federatif de Recherche 94, Universite\u0301 Paris-Descartes, 75015 Paris, France"}]}],"member":"291","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"2023072515264805900_BIB1","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4049\/jimmunol.148.6.1604","volume":"148","year":"1992","journal-title":"J. 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