{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:29:31Z","timestamp":1772137771648,"version":"3.50.1"},"reference-count":38,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,6,8]]},"abstract":"<jats:p>We describe new T cell receptor (TCR) transgenic mice (relapsing-remitting [RR] mice) carrying a TCR specific for myelin oligodendrocyte glycoprotein (MOG) peptide 92\u2013106 in the context of I-As. Backcrossed to the SJL\/J background, most RR mice spontaneously develop RR experimental autoimmune encephalomyelitis (EAE) with episodes often altering between different central nervous system tissues like the cerebellum, optic nerve, and spinal cord. Development of spontaneous EAE depends on the presence of an intact B cell compartment and on the expression of MOG autoantigen. There is no spontaneous EAE development in B cell\u2013depleted mice or in transgenic mice lacking MOG. Transgenic T cells seem to expand MOG autoreactive B cells from the endogenous repertoire. The expanded autoreactive B cells produce autoantibodies binding to a conformational epitope on the native MOG protein while ignoring the T cell target peptide. The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS.<\/jats:p>","DOI":"10.1084\/jem.20090299","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T20:46:01Z","timestamp":1243889161000},"page":"1303-1316","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":231,"title":["Spontaneous relapsing-remitting EAE in the SJL\/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells"],"prefix":"10.1084","volume":"206","author":[{"given":"Bernadette","family":"P\u00f6llinger","sequence":"first","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Gurumoorthy","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Kerstin","family":"Berer","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Hans","family":"Lassmann","sequence":"additional","affiliation":[{"name":"Center for Brain Research, Medical University of Vienna, A-1090 Vienna, Austria 3"}]},{"given":"Michael R.","family":"B\u00f6sl","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Robert","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Immunology, Biogen Idec, San Diego, CA 92122 4"}]},{"given":"Helena S.","family":"Domingues","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Andreas","family":"Holz","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Florian C.","family":"Kurschus","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]},{"given":"Hartmut","family":"Wekerle","sequence":"additional","affiliation":[{"name":"Department of Neuroimmunology 1 and 2"},{"name":"Transgenic Service, Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany 1 and 2"}]}],"member":"291","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2023072920195672800_bib1","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00109-007-0218-x","article-title":"Experimental models of spontaneous autoimmune disease in the central nervous system","volume":"85","author":"Krishnamoorthy","year":"2007","journal-title":"J. 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