{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:29:35Z","timestamp":1772137775104,"version":"3.50.1"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"8","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,8,2]]},"abstract":"<jats:p>Infection usually leads to the development of acquired immune responses associated with clearance or control of the infecting organism. However, if not adequately regulated, immune-mediated pathology can result. Tuberculosis is a worldwide threat, and development of an effective vaccine requires that the protective immune response to Mycobacterium tuberculosis (Mtb) be dissected from the pathological immune response. This distinction is particularly important if new vaccines are to be delivered to Mtb-exposed individuals, as repeated antigenic exposure can lead to pathological complications. Using a model wherein mice are vaccinated with bacille Calmette-Gu\u00e9rin after Mtb infection, we show that repeated vaccination results in increased IL-17, tumor necrosis factor, IL-6, and MIP-2 expression, influx of granulocytes\/neutrophils, and lung tissue damage. This pathological response is abrogated in mice deficient in the gene encoding IL-23p19 or in the presence of IL-17\u2013blocking antibody. This finding that repeated exposure to mycobacterial antigen promotes enhanced IL-17\u2013dependent pathological consequences has important implications for the design of effective vaccines against Mtb.<\/jats:p>","DOI":"10.1084\/jem.20100265","type":"journal-article","created":{"date-parts":[[2010,7,12]],"date-time":"2010-07-12T23:00:12Z","timestamp":1278975612000},"page":"1609-1616","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":226,"title":["Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with\n                    <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1084","volume":"207","author":[{"given":"Andrea","family":"Cruz","sequence":"first","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]},{"given":"Alexandra G.","family":"Fraga","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]},{"given":"Jeffrey J.","family":"Fountain","sequence":"additional","affiliation":[{"name":"Trudeau Institute, Saranac Lake, NY 12983 2"}]},{"given":"Javier","family":"Rangel-Moreno","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY 12208 3"}]},{"given":"Eg\u00eddio","family":"Torrado","sequence":"additional","affiliation":[{"name":"Trudeau Institute, Saranac Lake, NY 12983 2"}]},{"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]},{"given":"Daniela R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]},{"given":"Troy D.","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY 12208 3"}]},{"given":"Jorge","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]},{"given":"Andrea M.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Trudeau Institute, Saranac Lake, NY 12983 2"}]},{"given":"Ant\u00f3nio G.","family":"Castro","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, 4710-057 Braga, Portugal 1"}]}],"member":"291","published-online":{"date-parts":[[2010,7,12]]},"reference":[{"key":"2023072601500563600_bib1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jama.271.9.698","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. 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