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(https:\/\/doi.org\/10.1084\/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.<\/jats:p>","DOI":"10.1084\/jem.20160471","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T14:10:20Z","timestamp":1495548620000},"page":"2153-2156","update-policy":"https:\/\/doi.org\/10.1084\/jem.crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Tolerogenic insulin peptide therapy precipitates type 1 diabetes"],"prefix":"10.1084","volume":"214","author":[{"given":"Marie-Louise","family":"Bergman","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal 1"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1110-9816","authenticated-orcid":true,"given":"Thiago","family":"Lopes-Carvalho","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal 1"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8786-9424","authenticated-orcid":true,"given":"Ana-Catarina","family":"Martins","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal 1"}]},{"given":"Fabio A.","family":"Grieco","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2453-5889","authenticated-orcid":true,"given":"D\u00e9cio L.","family":"Eizirik","sequence":"additional","affiliation":[{"name":"Center for Diabetes Research, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium 2"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-614X","authenticated-orcid":true,"given":"Jocelyne","family":"Demengeot","sequence":"additional","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia, Oeiras, Portugal 1"}]}],"member":"291","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"2023072603570372200_bib1","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1939-4551-7-6","article-title":"Sublingual immunotherapy: World Allergy Organization position paper 2013 update","volume":"7","author":"Canonica","year":"2014","journal-title":"World Allergy Organ. 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