{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:59:18Z","timestamp":1774439958112,"version":"3.50.1"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"5","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,11,1]]},"abstract":"<jats:p>Olfactory neurons respond to odors with a change in conductance that mediates an influx of cations including Ca2+. The concomitant increase in [Cai] has been postulated to play a role in the adaptation to maintained odorant stimulation (Kurahashi, T., and T. Shibuya. 1990. Brain Research. 515:261-268. Kramer, R. H., and S. A. Siegelbaum. 1992. Neuron. 9:897-906. Zufall, F., G. M. Shepherd, and S. Firestein. 1991. Proceedings of the Royal Society of London, B. 246:225-230.) We have imaged the distribution of [Cai] in rat olfactory neurons (RON) using the Ca2+ indicator fura-2. A large percentage of the RON (42%, n = 35) responded to odorants with an increase in [Cai]. About half of the responding neurons displayed an increase in [Cai] at the apical end of the cell, but not at the soma. Moreover, in those cells that responded to odors with a standing [Cai] gradient, the gradient could be maintained for long periods of time (minutes) provided that the cells were continuously stimulated. In contrast, K(+)-induced depolarization elicited a more homogeneous increase in [Cai]. The spatially inhomogeneous increase in [Cai] elicited by odorants in some cells has important implications for the role of Ca2+ in adaptation because channels and enzymes regulated by Ca2+ will be affected differently depending on their location.<\/jats:p>","DOI":"10.1085\/jgp.102.5.907","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T23:51:34Z","timestamp":1084492294000},"page":"907-924","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Odorant-regulated Ca2+ gradients in rat olfactory neurons."],"prefix":"10.1085","volume":"102","author":[{"given":"D","family":"Restrepo","sequence":"first","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Okada","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Teeter","sequence":"additional","affiliation":[{"name":"Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1993,11,1]]},"container-title":["The Journal of general physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/102\/5\/907\/1767711\/907.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/102\/5\/907\/1767711\/907.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T10:31:03Z","timestamp":1690367463000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/102\/5\/907\/26320\/Odorant-regulated-Ca2-gradients-in-rat-olfactory"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,11,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.102.5.907","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11,1]]}}}