{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:25:18Z","timestamp":1791102318119,"version":"4.1.0"},"reference-count":74,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,6,1]]},"abstract":"<jats:p>The properties of inositol 1,4,5-trisphosphate (IP3)-dependent intracellular calcium oscillations in pancreatic acinar cells depend crucially on the agonist used to stimulate them. Acetylcholine or carbachol (CCh) cause high-frequency (10\u201312-s period) calcium oscillations that are superimposed on a raised baseline, while cholecystokinin (CCK) causes long-period (&amp;gt;100-s period) baseline spiking. We show that physiological concentrations of CCK induce rapid phosphorylation of the IP3 receptor, which is not true of physiological concentrations of CCh. Based on this and other experimental data, we construct a mathematical model of agonist-specific intracellular calcium oscillations in pancreatic acinar cells. Model simulations agree with previous experimental work on the rates of activation and inactivation of the IP3 receptor by calcium (DuFour, J.-F., I.M. Arias, and T.J. Turner. 1997. J. Biol. Chem. 272:2675\u20132681), and reproduce both short-period, raised baseline oscillations, and long-period baseline spiking. The steady state open probability curve of the model IP3 receptor is an increasing function of calcium concentration, as found for type-III IP3 receptors by Hagar et al. (Hagar, R.E., A.D. Burgstahler, M.H. Nathanson, and B.E. Ehrlich. 1998. Nature. 396:81\u201384). We use the model to predict the effect of the removal of external calcium, and this prediction is confirmed experimentally. We also predict that, for type-III IP3 receptors, the steady state open probability curve will shift to lower calcium concentrations as the background IP3 concentration increases. We conclude that the differences between CCh- and CCK-induced calcium oscillations in pancreatic acinar cells can be explained by two principal mechanisms: (a) CCK causes more phosphorylation of the IP3 receptor than does CCh, and the phosphorylated receptor cannot pass calcium current; and (b) the rate of calcium ATPase pumping and the rate of calcium influx from the outside the cell are greater in the presence of CCh than in the presence of CCK.<\/jats:p>","DOI":"10.1085\/jgp.113.6.851","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:50:20Z","timestamp":1027702220000},"page":"851-872","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":87,"title":["Agonist-dependent Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor"],"prefix":"10.1085","volume":"113","author":[{"given":"Andrew P.","family":"LeBeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Yule","sequence":"additional","affiliation":[{"name":"From the Mathematical Research Branch, National Institutes of Health, Bethesda, Maryland; \u2021Department of Physiology and \u00a7Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109-1109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy E.","family":"Groblewski","sequence":"additional","affiliation":[{"name":"From the Mathematical Research Branch, National Institutes of Health, Bethesda, Maryland; \u2021Department of Physiology and \u00a7Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109-1109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Sneyd","sequence":"additional","affiliation":[{"name":"From the Mathematical Research Branch, National Institutes of Health, Bethesda, Maryland; \u2021Department of Physiology and \u00a7Department of Mathematics, University of Michigan, Ann Arbor, Michigan 48109-1109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"2023072615464143600_B1","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/S0006-3495(93)81191-3","article-title":"A single-pool model for intra-cellular calcium oscillations and waves in the Xenopus laevisoocyte","volume":"65","author":"Atri","year":"1993","journal-title":"Biophysical J"},{"key":"2023072615464143600_B2","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1016\/S0021-9258(19)38704-6","article-title":"Calcium oscillations","volume":"265","author":"Berridge","year":"1990","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B3","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1091\/mbc.1.9.675","article-title":"Inositol trisphosphate analogues induce different oscillatory patterns in Xenopusoocytes","volume":"1","author":"Berridge","year":"1990","journal-title":"Cell Regul"},{"key":"2023072615464143600_B4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1113\/jphysiol.1997.sp021927","article-title":"Elementary and global aspects of calcium signalling","volume":"499","author":"Berridge","year":"1997","journal-title":"J Physiol"},{"key":"2023072615464143600_B5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0143-4160(94)90019-1","article-title":"Theoretical analysis of calcium wave propagation based on inositol (1,4,5)-trisphosphate (InsP3) receptor functional properties","volume":"16","author":"Bezprozvanny","year":"1994","journal-title":"Cell Calc"},{"key":"2023072615464143600_B6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00232713","article-title":"The inositol 1,4,5-trisphosphate (InsP3) receptor","volume":"145","author":"Bezprozvanny","year":"1995","journal-title":"J Membr Biol"},{"key":"2023072615464143600_B7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s004240050198","article-title":"Simultaneous presence of cAMP and cGMP exert a co-ordinated inhibitory effect on the agonist-evoked Ca2+signal in pancreatic acinar cells","volume":"432","author":"Camello","year":"1966","journal-title":"Pfl\u00fcgers Arch"},{"key":"2023072615464143600_B8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0092-8674(95)90124-8","article-title":"Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+flux","volume":"83","author":"Cameron","year":"1995","journal-title":"Cell"},{"key":"2023072615464143600_B9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/bj3280785","article-title":"Differential regulation of types-1 and -3 inositol trisphosphate receptor by cytosolic Ca2+","volume":"328","author":"Cardy","year":"1997","journal-title":"Biochem J"},{"key":"2023072615464143600_B10","doi-asserted-by":"crossref","first-page":"9895","DOI":"10.1073\/pnas.89.20.9895","article-title":"A single pool IP3-receptor based model for agonist stimulated Ca2+oscillations","volume":"89","author":"De Young","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072615464143600_B11","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1074\/jbc.272.5.2675","article-title":"Inositol 1,4,5-trisphosphate and calcium regulate the calcium channel function of the hepatic inositol 1,4,5-trisphosphate receptor","volume":"272","author":"Dufour","year":"1997","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B12","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0006-3495(96)79373-6","article-title":"Quantal release, incremental detection and long-period Ca2+ oscillations in a model based on regulatory Ca2+-binding sites along the permeation pathway","volume":"71","author":"Dupont","year":"1996","journal-title":"Biophys J"},{"key":"2023072615464143600_B13","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.2017683","article-title":"Calcium as a coagonist of inositol 1,4,5-trisphospate-induced calcium release","volume":"252","author":"Finch","year":"1991","journal-title":"Science"},{"key":"2023072615464143600_B14","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+indicators with greatly improved fluorescent properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/23954","article-title":"Type III InsP3receptor channel stays open in the presence of increased calcium","volume":"396","author":"Hagar","year":"1998","journal-title":"Nature"},{"key":"2023072615464143600_B16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/bj2930413","article-title":"Multiple mechanisms by which protein kinase A potentiates inositol 1,4,5-trisphosphate-induced Ca2+mobilization in permeabilized hepatocytes","volume":"293","author":"Hajn\u00f3czky","year":"1993","journal-title":"Biochem J"},{"key":"2023072615464143600_B17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/370474a0","article-title":"The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate","volume":"370","author":"Hajn\u00f3czky","year":"1994","journal-title":"Nature"},{"key":"2023072615464143600_B18","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1093\/emboj\/16.12.3533","article-title":"Minimal requirements for calcium oscillations driven by the IP3receptor","volume":"16","author":"Hajn\u00f3czky","year":"1997","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072615464143600_B19","doi-asserted-by":"crossref","first-page":"23059","DOI":"10.1016\/S0021-9258(19)49425-8","article-title":"Phosphorylation of the inositol trisphosphate receptor in isolated rat hepatocytes","volume":"268","author":"Joseph","year":"1993","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0898-6568(95)02012-8","article-title":"The inositol triphosphate receptor family","volume":"8","author":"Joseph","year":"1996","journal-title":"Cell Signal"},{"key":"2023072615464143600_B21","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1085\/jgp.110.5.529","article-title":"Inositol 1,4,5-trisphosphate (InsP3) and calcium interact to increase the dynamic range of InsP3receptor-dependent calcium signaling","volume":"110","author":"Kaftan","year":"1997","journal-title":"J Gen Physiol"},{"key":"2023072615464143600_B22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0092-8674(93)90514-Q","article-title":"Subcellular distribution of Ca2+ release channels underlying Ca2+waves and oscillations in exocrine pancreas","volume":"74","author":"Kasai","year":"1993","journal-title":"Cell"},{"key":"2023072615464143600_B23","doi-asserted-by":"crossref","first-page":"12859","DOI":"10.1016\/S0021-9258(18)51566-0","article-title":"Ca2+oscillations induced by hormonal stimulation of individual fura-2\u2013loaded hepatocytes","volume":"264","author":"Kawanishi","year":"1989","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/jtbi.1996.0365","article-title":"Signal-induced Ca2+ oscillations through the regulation of the inositol 1,4,5-trisphosphate-gated Ca2+channel: an allosteric model","volume":"186","author":"Laurent","year":"1997","journal-title":"J Theor Biol"},{"key":"2023072615464143600_B25","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/0143-4160(93)90096-O","article-title":"Two different spatiotemporal patterns for Ca2+ oscillations in pancreatic acinar cells: evidence of a role for protein kinase C in Ins(1,4,5)P3-mediated Ca2+signalling","volume":"14","author":"Lawrie","year":"1993","journal-title":"Cell Calc"},{"key":"2023072615464143600_B26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1073\/pnas.91.1.58","article-title":"Calcium oscillations in pituitary gonadotrophs: comparison of experiment and theory","volume":"91","author":"Li","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072615464143600_B27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jtbi.1994.1041","article-title":"Equations for InsP3 receptor-mediated [Ca2+] oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism","volume":"166","author":"Li","year":"1994","journal-title":"J Theor Biol"},{"key":"2023072615464143600_B28","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0006-3495(97)78758-7","article-title":"Sensing and refilling calcium stores in an excitable cell","volume":"72","author":"Li","year":"1997","journal-title":"Biophys J"},{"key":"2023072615464143600_B29","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0021-9258(18)52300-0","article-title":"Synchronized oscillation of Ca2+ entry and Ca2+release in agonist-stimulated AR42J cells","volume":"266","author":"Loessberg","year":"1991","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B30","doi-asserted-by":"crossref","first-page":"14483","DOI":"10.1016\/S0021-9258(19)49738-X","article-title":"Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps","volume":"2667","author":"Lytton","year":"1992","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bj3210573","article-title":"Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3receptors","volume":"321","author":"Marchant","year":"1997","journal-title":"Biochem J"},{"key":"2023072615464143600_B32","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1021\/bi980808k","article-title":"Rapid activation and partial inactivation of inositol trisphosphate receptors by inositol trisphosphate","volume":"37","author":"Marchant","year":"1998","journal-title":"Biochemistry"},{"key":"2023072615464143600_B33","doi-asserted-by":"crossref","first-page":"13214","DOI":"10.1016\/S0021-9258(19)38639-9","article-title":"Biphasic effects of cytosolic Ca2+ on Ins(1,4,5)P3-stimulated Ca2+mobilization in hepatocytes","volume":"268","author":"Marshall","year":"1993","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/bj2630333","article-title":"Relationship between hormonal, GTP and Ins(1,4,5)P3-stimulated Ca2+uptake and release in pancreatic acinar cells","volume":"263","author":"Muallem","year":"1989","journal-title":"Biochem J"},{"key":"2023072615464143600_B35","first-page":"305","article-title":"Regulation of intracellular calcium in epithelial cells","volume":"1","author":"Muallem","year":"1990","journal-title":"Semin Cell Biol"},{"key":"2023072615464143600_B36","doi-asserted-by":"crossref","first-page":"18118","DOI":"10.1016\/S0021-9258(19)37160-1","article-title":"Mechanism of Ca2+wave propagation in pancreatic acinar cells","volume":"267","author":"Nathanson","year":"1992","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B37","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1016\/S0021-9258(17)37597-X","article-title":"Localization of the type 3 inositol 1,4,5-trisphosphate receptor in the Ca2+wave trigger zone of pancreatic acinar cells","volume":"269","author":"Nathanson","year":"1994","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B38","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1074\/jbc.271.29.17253","article-title":"Reversible desensitization of inositol trisphosphate\u2013induced calcium release provides a mechanism for repetitive calcium spikes","volume":"271","author":"Oancea","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B39","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/j.1460-2075.1990.tb08162.x","article-title":"Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent C1\u2212current recording in single pancreatic acinar cells","volume":"9","author":"Osipchuk","year":"1990","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072615464143600_B40","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1073\/pnas.87.1.260","article-title":"Inhibition by Ca2+ of inositol trisphosphate\u2013mediated Ca2+ liberation: a possible mechanism for oscillatory release of Ca2+","volume":"87","author":"Parker","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072615464143600_B41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01868467","article-title":"Oscillating intracellular Ca2+signals evoked by activation of receptors linked to inositol lipid hydrolysis: mechanism of generation","volume":"118","author":"Petersen","year":"1990","journal-title":"J Membr Biol"},{"key":"2023072615464143600_B42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0143-4160(91)90015-7","article-title":"Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+signals","volume":"12","author":"Petersen","year":"1991","journal-title":"Cell Calc"},{"key":"2023072615464143600_B43","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/j.1460-2075.1991.tb07979.x","article-title":"Different patterns of receptor-activated cytoplasmic Ca2+ oscillations in single pancreatic acinar cells: dependence on receptor type, agonist concentration and intracellular Ca2+buffering","volume":"10","author":"Peterson","year":"1991","journal-title":"EMBO (Eur Mol Biol Organ) J"},{"key":"2023072615464143600_B44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/0006-291X(92)90675-B","article-title":"Cyclic AMP-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor inhibits Ca2+release from platelet membranes","volume":"184","author":"Quinton","year":"1992","journal-title":"Biochem Biophys Commun"},{"key":"2023072615464143600_B45"},{"key":"2023072615464143600_B46","doi-asserted-by":"crossref","first-page":"25899","DOI":"10.1074\/jbc.272.41.25899","article-title":"Molecular and functional evidence for multiple Ca2+-binding in the type I inositol 1,4,5-trisphosphate receptor","volume":"272","author":"Sienaert","year":"1997","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B47","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1096\/fasebj.9.14.7589988","article-title":"Mechanisms of calcium oscillations and waves: a quantitative analysis","volume":"9","author":"Sneyd","year":"1995","journal-title":"FASEB J"},{"key":"2023072615464143600_B48","doi-asserted-by":"crossref","first-page":"19769","DOI":"10.1016\/S0021-9258(19)36580-9","article-title":"Gap junction communication modulates [Ca2+]ioscillations and enzyme secretion in pancreatic acini","volume":"268","author":"Stauffer","year":"1993","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B49","doi-asserted-by":"crossref","first-page":"8747","DOI":"10.1073\/pnas.85.22.8747","article-title":"Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium","volume":"85","author":"Supattapone","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072615464143600_B50","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-3495(96)79567-X","article-title":"Simplification and analysis of models of calcium dynamics based on IP3-sensitive calcium channel kinetics","volume":"70","author":"Tang","year":"1996","journal-title":"Biophys J"},{"key":"2023072615464143600_B51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00237369","article-title":"Calcium and inositol trisphosphate receptors","volume":"145","author":"Taylor","year":"1995","journal-title":"J Membr Biol"},{"key":"2023072615464143600_B52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0005-2760(98)00122-2","article-title":"Inositol trisphosphate receptors: Ca2+-modulated intracellular Ca2+channels","volume":"1436","author":"Taylor","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"2023072615464143600_B53","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1073\/pnas.95.4.1613","article-title":"Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+release by cAMP-dependent protein kinase in a living cell","volume":"95","author":"Tertyshnikova","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2023072615464143600_B54","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0143-4160(93)90100-K","article-title":"Ca2+oscillations in pancreatic acinar cells: spatiotemporal relationships and functional implications","volume":"14","author":"Thorn","year":"1993","journal-title":"Cell Calc"},{"key":"2023072615464143600_B55","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0092-8674(93)90513-P","article-title":"Local and global cytosolic Ca2+oscillations in exocrine cells evoked by agonists and inositol trisphosphate","volume":"74","author":"Thorn","year":"1993","journal-title":"Cell"},{"key":"2023072615464143600_B56","doi-asserted-by":"crossref","first-page":"C147","DOI":"10.1152\/ajpcell.1990.258.1.C147","article-title":"Oscillatory model of calcium signaling in rat pancreatic acinar cells","volume":"258","author":"Tsunoda","year":"1990","journal-title":"Am J Physiol"},{"key":"2023072615464143600_B57","doi-asserted-by":"crossref","first-page":"C1086","DOI":"10.1152\/ajpcell.1990.258.6.C1086","article-title":"Regulation of inositol 1,4,5-trisphosphate\u2013induced Ca2+release II. Effect of cAMP- dependent protein kinase","volume":"258","author":"Volpe","year":"1990","journal-title":"Am J Physiol"},{"key":"2023072615464143600_B58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/339317a0","article-title":"Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration","volume":"339","author":"Wakui","year":"1989","journal-title":"Nature"},{"key":"2023072615464143600_B59","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1523\/JNEUROSCI.11-10-03239.1991","article-title":"Inositol 1,4,5-trisphosphate\u2013gated channels in cerebellum: presence of multiple conductance states","volume":"11","author":"Watras","year":"1991","journal-title":"J Neurosci"},{"key":"2023072615464143600_B60","first-page":"E517","article-title":"Action of secretagogues on a new preparation of functionally intact pancreatic acini","volume":"235","author":"Williams","year":"1978","journal-title":"Am J Physiol"},{"key":"2023072615464143600_B61","doi-asserted-by":"crossref","first-page":"11678","DOI":"10.1074\/jbc.270.19.11678","article-title":"Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell types","volume":"270","author":"Wojcikiewicz","year":"1995","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B62","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1074\/jbc.273.10.5670","article-title":"Phosphorylation in inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cells","volume":"273","author":"Wojcikiewicz","year":"1998","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B63","doi-asserted-by":"crossref","first-page":"29169","DOI":"10.1074\/jbc.270.49.29169","article-title":"Differential regulation of Ca2+ release-activated Ca2+influx by heterotrimeric G proteins","volume":"270","author":"Xu","year":"1995","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B64","doi-asserted-by":"crossref","first-page":"11737","DOI":"10.1074\/jbc.271.20.11737","article-title":"Regulation of the inositol 1,4,5-trisphosphate\u2013activated Ca2+by activation of G proteins","volume":"271","author":"Xu","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B65","doi-asserted-by":"crossref","first-page":"24684","DOI":"10.1074\/jbc.271.40.24684","article-title":"Spacial compartmentalization of Ca2+signaling complexes in pancreatic acini","volume":"271","author":"Xu","year":"1996","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B66","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0143-4160(97)90015-4","article-title":"nNOS and Ca2+influx in rat pancreatic acinar and submandibular salivary gland cells","volume":"22","author":"Xu","year":"1997","journal-title":"Cell Calc"},{"key":"2023072615464143600_B67","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bj3220591","article-title":"Ca2+differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors","volume":"322","author":"Yoneshima","year":"1997","journal-title":"Biochem J"},{"key":"2023072615464143600_B68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0021-5198(19)31401-5","article-title":"Structure and function and inositol 1,4,5-trisphosphate receptor","volume":"74","author":"Yoshida","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"2023072615464143600_B69","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0014-5793(88)80951-7","article-title":"Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine","volume":"239","author":"Yule","year":"1988","journal-title":"FEBS Lett"},{"key":"2023072615464143600_B70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0143-4160(91)90016-8","article-title":"Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells","volume":"12","author":"Yule","year":"1991","journal-title":"Cell Calc"},{"key":"2023072615464143600_B71","first-page":"G999","article-title":"A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists","volume":"265","author":"Yule","year":"1993","journal-title":"Am J Physiol"},{"key":"2023072615464143600_B72","doi-asserted-by":"crossref","first-page":"C1285","DOI":"10.1152\/ajpcell.1996.271.4.C1285","article-title":"Intercellular calcium waves in rat pancreatic acini: mechanism of transmission","volume":"271","author":"Yule","year":"1996","journal-title":"Am J Physiol"},{"key":"2023072615464143600_B73","doi-asserted-by":"crossref","first-page":"15419","DOI":"10.1016\/S0021-9258(19)49550-1","article-title":"Activation of the plasma membrane Ca2+pump during agonist stimulation of pancreatic acini","volume":"267","author":"Zhang","year":"1992","journal-title":"J Biol Chem"},{"key":"2023072615464143600_B74","doi-asserted-by":"crossref","first-page":"7214","DOI":"10.1021\/bi952471h","article-title":"Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase","volume":"35","author":"Zhu","year":"1996","journal-title":"Biochemistry"}],"container-title":["The Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/113\/6\/851\/1772998\/gp-7887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/113\/6\/851\/1772998\/gp-7887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T18:41:32Z","timestamp":1690396892000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/113\/6\/851\/26794\/Agonist-dependent-Phosphorylation-of-the-Inositol"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6,1]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.113.6.851","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6,1]]}}}