{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:07:11Z","timestamp":1792570031014,"version":"4.5.0"},"reference-count":31,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:p>Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K+ channels and has been proposed to be the acute O2 sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O2 sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K+ channel \u03b1-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K+ channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O2-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K+ channel gene expression but it does not alter the intrinsic O2 sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O2 sensor.<\/jats:p>","DOI":"10.1085\/jgp.200609591","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:31:53Z","timestamp":1158021113000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["Acute Oxygen Sensing in Heme Oxygenase-2 Null Mice"],"prefix":"10.1085","volume":"128","author":[{"given":"Patricia","family":"Ortega-Sa\u0301enz","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaciones Biome\u0301dicas, Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pascual","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Biome\u0301dicas, Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Go\u0301mez-Di\u0301az","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Biome\u0301dicas, Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301","family":"Lo\u0301pez-Barneo","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaciones Biome\u0301dicas, Hospital Universitario Virgen del Roci\u0301o, Universidad de Sevilla, Sevilla 41013, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2006,9,11]]},"reference":[{"key":"2023072620434917700_BIB1","doi-asserted-by":"crossref","first-page":"7944","DOI":"10.1073\/pnas.96.14.7944","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072620434917700_BIB2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.bbrc.2004.05.195","volume":"320","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023072620434917700_BIB3","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","volume":"287","year":"2000","journal-title":"Science."},{"key":"2023072620434917700_BIB4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0891-5849(02)00805-5","volume":"32","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"2023072620434917700_BIB5","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1073\/pnas.96.5.2445","volume":"96","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072620434917700_BIB6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0306-4522(00)00216-5","volume":"99","year":"2000","journal-title":"Neuroscience."},{"key":"2023072620434917700_BIB7","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1073\/pnas.97.8.4374","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072620434917700_BIB8","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1126\/science.1107069","volume":"306","year":"2004","journal-title":"Science."},{"key":"2023072620434917700_BIB9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/01.RES.87.9.789","volume":"87","year":"2000","journal-title":"Circ. Res."},{"key":"2023072620434917700_BIB10","doi-asserted-by":"crossref","first-page":"C167","DOI":"10.1152\/ajpcell.1998.274.1.C167","volume":"274","year":"1998","journal-title":"Am. J. Physiol."},{"key":"2023072620434917700_BIB11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.2456613","volume":"241","year":"1988","journal-title":"Science."},{"key":"2023072620434917700_BIB12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","volume":"63","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"2023072620434917700_BIB13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.200509338","volume":"126","year":"2005","journal-title":"J. Gen. Physiol."},{"key":"2023072620434917700_BIB14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/9780470035009.ch6","volume":"272","year":"2006","journal-title":"Novartis Found. Symp."},{"key":"2023072620434917700_BIB15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev.pharmtox.37.1.517","volume":"37","year":"1997","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2023072620434917700_BIB16","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1161\/CIRCULATIONAHA.104.529404","volume":"112","year":"2005","journal-title":"Circulation."},{"key":"2023072620434917700_BIB17","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1073\/pnas.030522297","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072620434917700_BIB18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nn812","volume":"5","year":"2002","journal-title":"Nat. Neurosci."},{"key":"2023072620434917700_BIB19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1113\/jphysiol.2004.062281","volume":"557","year":"2004","journal-title":"J. Physiol."},{"key":"2023072620434917700_BIB20","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1128\/MCB.24.24.10933-10940.2004","volume":"24","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2023072620434917700_BIB21","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0896-6273(95)90177-9","volume":"15","year":"1995","journal-title":"Neuron."},{"key":"2023072620434917700_BIB22","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1152\/jappl.2000.88.6.2287","volume":"88","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"2023072620434917700_BIB23","first-page":"1","volume":"358","year":"1985","journal-title":"J. Physiol."},{"key":"2023072620434917700_BIB24","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1073\/pnas.82.23.7865","volume":"82","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072620434917700_BIB25","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nature02003","volume":"425","year":"2003","journal-title":"Nature."},{"key":"2023072620434917700_BIB26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1113\/jphysiol.1997.sp021876","volume":"498","year":"1997","journal-title":"J. Physiol."},{"key":"2023072620434917700_BIB27","doi-asserted-by":"crossref","first-page":"8222","DOI":"10.1074\/jbc.272.13.8222","volume":"272","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2023072620434917700_BIB28","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra050002","volume":"353","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2023072620434917700_BIB29","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1126\/science.1105010","volume":"306","year":"2004","journal-title":"Science."},{"key":"2023072620434917700_BIB30","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.1995.sp020606","volume":"483","year":"1995","journal-title":"J. Physiol."},{"key":"2023072620434917700_BIB31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1073\/pnas.92.1.295","volume":"92","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA."}],"container-title":["The Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/128\/4\/405\/1783396\/405.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/128\/4\/405\/1783396\/405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T11:33:16Z","timestamp":1707219196000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/128\/4\/405\/42627\/Acute-Oxygen-Sensing-in-Heme-Oxygenase-2-Null-Mice"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,11]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.200609591","relation":{},"ISSN":["1540-7748","0022-1295"],"issn-type":[{"value":"1540-7748","type":"electronic"},{"value":"0022-1295","type":"print"}],"subject":[],"published":{"date-parts":[[2006,9,11]]}}}