{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:50:32Z","timestamp":1788461432610,"version":"build-2803163510"},"reference-count":38,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:p>Adjustment of the Na\/K ATPase activity to changes in oxygen availability is a matter of survival for neuronal cells. We have used freshly isolated rat cerebellar granule cells to study oxygen sensitivity of the Na\/K ATPase function. Along with transport and hydrolytic activity of the enzyme we have monitored alterations in free radical production, cellular reduced glutathione, and ATP levels. Both active K+ influx and ouabain-sensitive inorganic phosphate production were maximal within the physiological pO2 range of 3\u20135 kPa. Transport and hydrolytic activity of the Na\/K ATPase was equally suppressed under hypoxic and hyperoxic conditions. The ATPase response to changes in oxygenation was isoform specific and limited to the \u03b11-containing isozyme whereas \u03b12\/3-containing isozymes were oxygen insensitive. Rapid activation of the enzyme within a narrow window of oxygen concentrations did not correlate with alterations in the cellular ATP content or substantial shifts in redox potential but was completely abolished when NO production by the cells was blocked by l-NAME. Taken together our observations suggest that NO and its derivatives are involved in maintenance of high Na\/K ATPase activity under physiological conditions.<\/jats:p>","DOI":"10.1085\/jgp.200709783","type":"journal-article","created":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T17:48:31Z","timestamp":1190656111000},"page":"389-398","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Oxygen-induced Regulation of Na\/K ATPase in Cerebellar Granule Cells"],"prefix":"10.1085","volume":"130","author":[{"given":"Irina Yu.","family":"Petrushanko","sequence":"first","affiliation":[{"name":"1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology (ZIHP), University of Zurich, Zurich CH-8057, Switzerland"},{"name":"2Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai B.","family":"Bogdanov","sequence":"additional","affiliation":[{"name":"1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology (ZIHP), University of Zurich, Zurich CH-8057, Switzerland"},{"name":"3International Biotechnological Center of Lomonosov, Department of Biochemistry, Moscow State University, Moscow, 119992 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lapina","sequence":"additional","affiliation":[{"name":"1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology (ZIHP), University of Zurich, Zurich CH-8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Boldyrev","sequence":"additional","affiliation":[{"name":"3International Biotechnological Center of Lomonosov, Department of Biochemistry, Moscow State University, Moscow, 119992 Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Gassmann","sequence":"additional","affiliation":[{"name":"1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology (ZIHP), University of Zurich, Zurich CH-8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Yu.","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"1Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology (ZIHP), University of Zurich, Zurich CH-8057, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2007,9,24]]},"reference":[{"key":"2023072920403437900_BIB1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.freeradbiomed.2005.03.017","volume":"39","year":"2005","journal-title":"Free Radic. 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