{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:39:14Z","timestamp":1790642354236,"version":"4.1.0"},"reference-count":70,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>Background K+ channels of the TASK family are believed to participate in sensory transduction by chemoreceptor (glomus) cells of the carotid body (CB). However, studies on the systemic CB-mediated ventilatory response to hypoxia and hypercapnia in TASK1- and\/or TASK3-deficient mice have yielded conflicting results. We have characterized the glomus cell phenotype of TASK-null mice and studied the responses of individual cells to hypoxia and other chemical stimuli. CB morphology and glomus cell size were normal in wild-type as well as in TASK1\u2212\/\u2212 or double TASK1\/3\u2212\/\u2212 mice. Patch-clamped TASK1\/3-null glomus cells had significantly higher membrane resistance and less hyperpolarized resting potential than their wild-type counterpart. These electrical parameters were practically normal in TASK1\u2212\/\u2212 cells. Sensitivity of background currents to changes of extracellular pH was drastically diminished in TASK1\/3-null cells. In contrast with these observations, responsiveness to hypoxia or hypercapnia of either TASK1\u2212\/\u2212 or double TASK1\/3\u2212\/\u2212 cells, as estimated by the amperometric measurement of catecholamine release, was apparently normal. TASK1\/3 knockout cells showed an enhanced secretory rate in basal (normoxic) conditions compatible with their increased excitability. Responsiveness to hypoxia of TASK1\/3-null cells was maintained after pharmacological blockade of maxi-K+ channels. These data in the TASK-null mouse model indicate that TASK3 channels contribute to the background K+ current in glomus cells and to their sensitivity to external pH. They also suggest that, although TASK1 channels might be dispensable for O2\/CO2 sensing in mouse CB cells, TASK3 channels (or TASK1\/3 heteromers) could mediate hypoxic depolarization of normal glomus cells. The ability of TASK1\/3\u2212\/\u2212 glomus cells to maintain a powerful response to hypoxia even after blockade of maxi-K+ channels, suggests the existence of multiple sensor and\/or effector mechanisms, which could confer upon the cells a high adaptability to maintain their chemosensory function.<\/jats:p>","DOI":"10.1085\/jgp.200910302","type":"journal-article","created":{"date-parts":[[2010,3,29]],"date-time":"2010-03-29T14:53:19Z","timestamp":1269874399000},"page":"379-392","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":88,"title":["Carotid body chemosensory responses in mice deficient of TASK channels"],"prefix":"10.1085","volume":"135","author":[{"given":"Patricia","family":"Ortega-S\u00e1enz","sequence":"first","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin L.","family":"Levitsky","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Marcos-Almaraz","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Bonilla-Henao","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pascual","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"L\u00f3pez-Barneo","sequence":"additional","affiliation":[{"name":"Instituto de Biomedicina de Sevilla (IBIS) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Universitario Virgen del Roc\u00edo, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, 41013 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,3,29]]},"reference":[{"key":"2023072521313941600_bib1","doi-asserted-by":"publisher","first-page":"11455","DOI":"10.1523\/JNEUROSCI.3153-05.2005","article-title":"Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons","volume":"25","author":"Aller","year":"2005","journal-title":"J. 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