{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:01:51Z","timestamp":1792008111714,"version":"4.4.0"},"reference-count":65,"publisher":"Rockefeller University Press","issue":"4","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,10,1]]},"abstract":"<jats:p>Tetanic electrical stimulation induces two separate calcium signals in rat skeletal myotubes, a fast one, dependent on Cav 1.1 or dihydropyridine receptors (DHPRs) and ryanodine receptors and related to contraction, and a slow signal, dependent on DHPR and inositol trisphosphate receptors (IP3Rs) and related to transcriptional events. We searched for slow calcium signals in adult muscle fibers using isolated adult flexor digitorum brevis fibers from 5\u20137-wk-old mice, loaded with fluo-3. When stimulated with trains of 0.3-ms pulses at various frequencies, cells responded with a fast calcium signal associated with muscle contraction, followed by a slower signal similar to one previously described in cultured myotubes. Nifedipine inhibited the slow signal more effectively than the fast one, suggesting a role for DHPR in its onset. The IP3R inhibitors Xestospongin B or C (5 \u00b5M) also inhibited it. The amplitude of post-tetanic calcium transients depends on both tetanus frequency and duration, having a maximum at 10\u201320 Hz. At this stimulation frequency, an increase of the slow isoform of troponin I mRNA was detected, while the fast isoform of this gene was inhibited. All three IP3R isoforms were present in adult muscle. IP3R-1 was differentially expressed in different types of muscle fibers, being higher in a subset of fast-type fibers. Interestingly, isolated fibers from the slow soleus muscle did not reveal the slow calcium signal induced by electrical stimulus. These results support the idea that IP3R-dependent slow calcium signals may be characteristic of distinct types of muscle fibers and may participate in the activation of specific transcriptional programs of slow and fast phenotype.<\/jats:p>","DOI":"10.1085\/jgp.200910397","type":"journal-article","created":{"date-parts":[[2010,9,14]],"date-time":"2010-09-14T00:39:58Z","timestamp":1284424798000},"page":"455-467","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["IP3-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers"],"prefix":"10.1085","volume":"136","author":[{"given":"Mariana","family":"Casas","sequence":"first","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 1"},{"name":"Escuela de Tecnolog\u00eda M\u00e9dica, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Jorquera","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Escobar","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Molg\u00f3","sequence":"additional","affiliation":[{"name":"Institut de Neurobiologie Alfred Fessard, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette cedex, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Jaimovich","sequence":"additional","affiliation":[{"name":"Centro de Estudios Moleculares de la C\u00e9lula, ICBM, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2010,9,13]]},"reference":[{"key":"2023072521352676900_bib1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1085\/jgp.20028671","article-title":"Dihydropyridine receptors as voltage sensors for a depolarization-evoked, IP3R-mediated, slow calcium signal in skeletal muscle cells","volume":"121","author":"Araya","year":"2003","journal-title":"J. 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