{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:13:02Z","timestamp":1789974782857,"version":"4.0.1"},"reference-count":26,"publisher":"Rockefeller University Press","issue":"5","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL057832"],"award-info":[{"award-number":["HL057832"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR054098"],"award-info":[{"award-number":["AR054098"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM11397"],"award-info":[{"award-number":["GM11397"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,5,1]]},"DOI":"10.1085\/jgp.201611599","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T13:19:31Z","timestamp":1461590371000},"page":"369-373","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Approaching ryanodine receptor therapeutics from the calcin angle"],"prefix":"10.1085","volume":"147","author":[{"given":"Josefina","family":"Ramos-Franco","sequence":"first","affiliation":[{"name":"Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fill","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2016,4,25]]},"reference":[{"key":"2023072623464196600_bib1","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00424-010-0794-4","article-title":"Ryanodine receptor channelopathies","volume":"460","author":"Betzenhauser","year":"2010","journal-title":"Pflugers Arch."},{"key":"2023072623464196600_bib2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.bbamem.2006.02.007","article-title":"Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor","volume":"1758","author":"Boisseau","year":"2006","journal-title":"Biochim. Biophys. Acta."},{"key":"2023072623464196600_bib3","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.ejphar.2013.11.012","article-title":"Calcium channelopathies and Alzheimer\u2019s disease: insight into therapeutic success and failures","volume":"739","author":"Chakroborty","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"2023072623464196600_bib4","doi-asserted-by":"publisher","first-page":"2436","DOI":"10.1016\/S0006-3495(02)75587-2","article-title":"Role of the proposed pore-forming segment of the Ca2+ release channel (ryanodine receptor) in ryanodine interaction","volume":"82","author":"Chen","year":"2002","journal-title":"Biophys. J."},{"key":"2023072623464196600_bib5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0006-3495(97)78055-X","article-title":"Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors","volume":"73","author":"Copello","year":"1997","journal-title":"Biophys. J."},{"key":"2023072623464196600_bib6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1113\/jphysiol.1958.sp006034","article-title":"The ionic requirements for the production of action potentials in crustacean muscle fibres","volume":"142","author":"Fatt","year":"1958","journal-title":"J. Physiol."},{"key":"2023072623464196600_bib7","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.3390\/ph3041093","article-title":"Imperatoxin A, a cell-penetrating peptide from scorpion venom, as a probe of Ca-release channels\/ryanodine receptors","volume":"3","author":"Gurrola","year":"2010","journal-title":"Pharmaceuticals (Basel)."},{"key":"2023072623464196600_bib8","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/sj.bjp.0704307","article-title":"Effects of dantrolene and its derivatives on Ca2+ release from the sarcoplasmic reticulum of mouse skeletal muscle fibres","volume":"134","author":"Ikemoto","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"2023072623464196600_bib9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/WAD.0000000000000076","article-title":"Dantrolene, a treatment for Alzheimer disease?","volume":"29","author":"Liang","year":"2015","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"2023072623464196600_bib10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1085\/jgp.104.3.425","article-title":"How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca2+-release channel?","volume":"104","author":"Lindsay","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"2023072623464196600_bib11","unstructured":"Liu, Y.\n          \n          2008. Ryanodine receptor function in intracellular calcium signaling. PhD dissertation. ProQuest\/UMI #3345086. Loyola University Chicago, Chicago. 126 pp."},{"key":"2023072623464196600_bib12","doi-asserted-by":"publisher","first-page":"e0125366","DOI":"10.1371\/journal.pone.0125366","article-title":"Antiarrhythmic Effects of dantrolene in patients with catecholaminergic polymorphic ventricular tachycardia and replication of the responses using iPSC models","volume":"10","author":"Penttinen","year":"2015","journal-title":"PLoS One."},{"key":"2023072623464196600_bib13","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00424-009-0658-y","article-title":"Trifluoperazine: a rynodine receptor agonist","volume":"458","author":"Qin","year":"2009","journal-title":"Pflugers Arch."},{"key":"2023072623464196600_bib14","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00424-010-0839-8","article-title":"Ryanodol action on calcium sparks in ventricular myocytes","volume":"460","author":"Ramos-Franco","year":"2010","journal-title":"Pflugers Arch."},{"key":"2023072623464196600_bib15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1085\/jgp.201411321","article-title":"The couplonopathies: A comparative approach to a class of diseases of skeletal and cardiac muscle","volume":"145","author":"R\u00edos","year":"2015","journal-title":"J. Gen. Physiol."},{"key":"2023072623464196600_bib16","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1083\/jcb.146.2.493","article-title":"Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor","volume":"146","author":"Sams\u00f3","year":"1999","journal-title":"J. Cell Biol."},{"key":"2023072623464196600_bib17","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1476-5381.2009.00147.x","article-title":"Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors","volume":"157","author":"Schwartz","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"2023072623464196600_bib18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s002329900113","article-title":"Modification of the conductance and gating properties of ryanodine receptors by suramin","volume":"153","author":"Sitsapesan","year":"1996","journal-title":"J. Membr. Biol."},{"key":"2023072623464196600_bib19","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1161\/01.RES.0000032490.04207.BD","article-title":"Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes","volume":"91","author":"Terentyev","year":"2002","journal-title":"Circ. Res."},{"key":"2023072623464196600_bib20","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1085\/jgp.111.5.679","article-title":"Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle","volume":"111","author":"Tripathy","year":"1998","journal-title":"J. Gen. Physiol."},{"key":"2023072623464196600_bib21","doi-asserted-by":"publisher","first-page":"12185","DOI":"10.1073\/pnas.89.24.12185","article-title":"Scorpion toxins targeted against the sarcoplasmic reticulum Ca2+-release channel of skeletal and cardiac muscle","volume":"89","author":"Valdivia","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072623464196600_bib22","doi-asserted-by":"publisher","first-page":"2321.e1","DOI":"10.1016\/j.neurobiolaging.2010.05.004","article-title":"Carvedilol as a potential novel agent for the treatment of Alzheimer\u2019s disease","volume":"32","author":"Wang","year":"2011","journal-title":"Neurobiol. Aging."},{"key":"2023072623464196600_bib23","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201511499","article-title":"Structure\u2013function relationships of peptides forming the calcin family of ryanodine receptor ligands","author":"Xiao","year":"2016","journal-title":"J. Gen. Physiol."},{"key":"2023072623464196600_bib24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1042\/BJ20150548","article-title":"Non-\u03b2-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure","volume":"470","author":"Zhang","year":"2015","journal-title":"Biochem. J."},{"key":"2023072623464196600_bib25","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nm.2406","article-title":"Carvedilol and its new analogs suppress arrhythmogenic store overload\u2013induced Ca2+ release","volume":"17","author":"Zhou","year":"2011","journal-title":"Nat. Med."},{"key":"2023072623464196600_bib26","doi-asserted-by":"publisher","first-page":"H2008","DOI":"10.1152\/ajpheart.00523.2008","article-title":"Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes","volume":"295","author":"Zima","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/147\/5\/369\/1795425\/jgp_201611599.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/147\/5\/369\/1795425\/jgp_201611599.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T23:46:51Z","timestamp":1690415211000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/147\/5\/369\/43521\/Approaching-ryanodine-receptor-therapeutics-from"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,25]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.201611599","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,25]]}}}