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Routine exercise has been shown to improve cardiac function, morphology, and molecular signatures. Likewise, the acute and chronic changes that occur in the heart in response to injury, disease, and stress are well characterized, albeit not fully understood. In this study, we investigated how exercise and myocardial injury affect contraction\u2013relaxation coupling. We retrospectively analyzed the correlation between the maximal speed of contraction and the maximal speed of relaxation of canine myocardium after receiving surgically induced myocardial infarction, followed by either sedentary recovery or exercise training for 10\u201312 wk. We used isolated right ventricular trabeculae, which were electrically paced at different lengths, frequencies, and with increasing \u03b2-adrenoceptor stimulation. In all conditions, contraction and relaxation were linearly correlated, irrespective of injury or training history. Based on these results and the available literature, we posit that contraction\u2013relaxation coupling is a fundamental myocardial property that resides in the structural arrangement of proteins at the level of the sarcomere and that this may be regulated by the actions of cardiac myosin binding protein C (cMyBP-C) on actin and myosin.<\/jats:p>","DOI":"10.1085\/jgp.202012829","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T01:39:48Z","timestamp":1618364388000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Contraction\u2013relaxation coupling is unaltered by exercise training and infarction in isolated canine myocardium"],"prefix":"10.1085","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-5731","authenticated-orcid":true,"given":"Farbod","family":"Fazlollahi","sequence":"first","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge J.","family":"Santini Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-4748","authenticated-orcid":true,"given":"Steven J.","family":"Repas","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-443X","authenticated-orcid":true,"given":"Benjamin D.","family":"Canan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George E.","family":"Billman","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3014","authenticated-orcid":true,"given":"Paul M.L.","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine, Ohio State University, Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"2023072707360558200_bib1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.jmb.2008.09.065","article-title":"Myosin binding protein C positioned to play a key role in regulation of muscle contraction: structure and interactions of domain C1","volume":"384","author":"Ababou","year":"2008","journal-title":"J. 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