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Significant spike rate changes with respect to basal firing rate were observed for optical activations lasting 200 ms and 1 s as well as for 1 s long trains of 10 ms pulses at 50 Hz. For all conditions, the net effect of optical activation on the integrated spike rate is significantly reduced because of PSS. Three lines of evidence indicate that this PSS is due to intrinsic factors. Firstly, PSS is induced when the optical stimulation is restricted to a single MLI using a 405-nm laser delivering a diffraction-limited spot at the focal plane. Secondly, PSS is not affected by block of GABA-A or GABA-B receptors, ruling out synaptic interactions amongst MLIs. Thirdly, PSS is mimicked in whole-cell recording experiments by step depolarizations under current clamp. Activation of Ca-dependent K channels during the spike trains appears as a likely candidate to underlie PSS. Using immunocytochemistry, we find that one such channel type, KCa1.1, is present in the somato-dendritic and axonal compartments of MLIs. In cell-attached recordings, charybdotoxin and iberiotoxin significantly reduce the optically induced PSS, while TRAM-34 does not affect it, suggesting that KCa1.1 channels, but not KCa3.1 channels, contribute to PSS.<\/jats:p>","DOI":"10.1085\/jgp.202113004","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T13:53:06Z","timestamp":1667483586000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["KCa1.1 channels contribute to optogenetically driven post-stimulation silencing in cerebellar molecular layer interneurons"],"prefix":"10.1085","volume":"155","author":[{"given":"Merouann","family":"Kassa","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, Saints-P\u00e8res Paris Institute for the Neurosciences, Paris, France 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6933-1153","authenticated-orcid":true,"given":"Jonathan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Superieure (IBENS), Ecole Normale Superieure, Centre National de la Recherche Scientifique, INSERM, Paris Sciences et Lettres Research University, Paris, France 2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-8735","authenticated-orcid":true,"given":"Abdelali","family":"Jalil","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, Saints-P\u00e8res Paris Institute for the Neurosciences, Paris, France 1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-9711","authenticated-orcid":true,"given":"Isabel","family":"Llano","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Centre National de la Recherche Scientifique, Saints-P\u00e8res Paris Institute for the Neurosciences, Paris, France 1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"2022122114504355400_bib1","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1152\/jn.1999.82.4.1697","article-title":"Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum","volume":"82","author":"Aizenman","year":"1999","journal-title":"J. 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