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The GI tract, especially the colon, is the home base for gut microbiome which dynamically regulates immune function. The gut\u2019s immune system also provides an effective defense against harmful pathogens entering the GI tract while maintaining immune homeostasis to avoid exaggerated immune reaction to innocuous food and commensal antigens which are important causes of inflammatory disorders such as coeliac disease and inflammatory bowel diseases (IBD). Various ion channels have been detected in multiple cell types throughout the GI tract. By regulating membrane properties and intracellular biochemical signaling, ion channels play a critical role in synchronized signaling among diverse cellular components in the gut that orchestrates the GI immune response. This work focuses on the role of ion channels in immune cells, non-immune resident cells, and neuroimmune interactions in the gut at the steady state and pathological conditions. Understanding the cellular and molecular basis of ion channel signaling in these immune-related pathways and initial testing of pharmacological intervention will facilitate the development of ion channel\u2013based therapeutic approaches for the treatment of intestinal inflammation.<\/jats:p>","DOI":"10.1085\/jgp.202113042","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T15:45:14Z","timestamp":1669995914000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Ion channel regulation of gut immunity"],"prefix":"10.1085","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-7912","authenticated-orcid":true,"given":"Jing","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 1"},{"name":"Center for Neurological and Psychiatric Research and Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zili","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8967-7522","authenticated-orcid":true,"given":"Hongzhen","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2022,12,2]]},"reference":[{"key":"2022120215450127400_bib1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1101\/pdb.top083329","article-title":"Optogenetics: Opsins and optical interfaces in neuroscience","volume":"2014","author":"Adamantidis","year":"2014","journal-title":"Cold Spring Harb. 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