{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:33:41Z","timestamp":1778643221204,"version":"3.51.4"},"reference-count":205,"publisher":"Rockefeller University Press","issue":"3","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":328,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["0630236N"],"award-info":[{"award-number":["0630236N"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Established Investigator Award","award":["0340160N"],"award-info":[{"award-number":["0340160N"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL122865"],"award-info":[{"award-number":["R01 HL122865"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL108232"],"award-info":[{"award-number":["HL108232"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL64043"],"award-info":[{"award-number":["HL64043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,6]]},"abstract":"<jats:p>Pulmonary hypertension (PH) is a devastating disease characterized by a progressive increase in pulmonary arterial pressure leading to right ventricular failure and death. A major cellular response in this disease is the contraction of smooth muscle cells (SMCs) of the pulmonary vasculature. Cell contraction is determined by the increase in intracellular Ca2+ concentration ([Ca2+]i), which is generated and regulated by various ion channels. Several studies by us and others have shown that ryanodine receptor 2 (RyR2), a Ca2+-releasing channel in the sarcoplasmic reticulum (SR), is an essential ion channel for the control of [Ca2+]i in pulmonary artery SMCs (PASMCs), thereby mediating the sustained vasoconstriction seen in PH. FK506-binding protein 12.6 (FKBP12.6) strongly associates with RyR2 to stabilize its functional activity. FKBP12.6 can be dissociated from RyR2 by a hypoxic stimulus to increase channel function and Ca2+ release, leading to pulmonary vasoconstriction and PH. More specifically, dissociation of the RyR2\u2013FKBP12.6 complex is a consequence of increased mitochondrial ROS generation mediated by the Rieske iron-sulfur protein (RISP) at the mitochondrial complex III after hypoxia. Overall, RyR2\/FKBP12.6 dissociation and the corresponding signaling pathway may be an important factor in the development of PH. Novel drugs and biologics targeting RyR2, FKBP12.6, and related molecules may become unique effective therapeutics for PH.<\/jats:p>","DOI":"10.1085\/jgp.202213100","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:05:31Z","timestamp":1673363131000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Role of ryanodine receptor 2 and FK506-binding protein 12.6 dissociation in pulmonary hypertension"],"prefix":"10.1085","volume":"155","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7483-3844","authenticated-orcid":true,"given":"Yong-Xiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Albany Medical College 1 , Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6226-7363","authenticated-orcid":true,"given":"Jorge","family":"Reyes-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Albany Medical College 1 , Albany, NY, USA"},{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 2 Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-4917","authenticated-orcid":true,"given":"Annarita","family":"Di Mise","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Albany Medical College 1 , Albany, NY, USA"},{"name":"Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari 3 , Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Min","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Physiology, Albany Medical College 1 , Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"2023011015040679600_bib1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1569-9048(02)00053-8","article-title":"Endothelium-derived mediators and hypoxic pulmonary vasoconstriction","volume":"132","author":"Aaronson","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"2023011015040679600_bib2","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/s41569-020-00443-x","article-title":"Mechanisms of ryanodine receptor 2 dysfunction in heart failure","volume":"17","author":"Alvarado","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"2023011015040679600_bib3","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.cmet.2011.05.014","article-title":"Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging","volume":"14","author":"Andersson","year":"2011","journal-title":"Cell Metab."},{"key":"2023011015040679600_bib4","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.115.020951","article-title":"Potassium channel subfamily K member 3 (KCNK3) contributes to the development of pulmonary arterial hypertension","volume":"133","author":"Antigny","year":"2016","journal-title":"Circulation"},{"key":"2023011015040679600_bib5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1152\/nips.01388.2002","article-title":"The mechanism(s) of hypoxic pulmonary vasoconstriction: Potassium channels, redox O2 sensors, and controversies","volume":"17","author":"Archer","year":"2002","journal-title":"News Physiol. Sci."},{"key":"2023011015040679600_bib6","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1161\/01.RES.73.6.1100","article-title":"A redox-based O2 sensor in rat pulmonary vasculature","volume":"73","author":"Archer","year":"1993","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib7","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1172\/JCI333","article-title":"Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes","volume":"101","author":"Archer","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2023011015040679600_bib8","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1152\/japplphysiol.00890.2002","article-title":"Human pulmonary vascular response to 4 h of hypercapnia and hypocapnia measured using Doppler echocardiography","volume":"94","author":"Balanos","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"2023011015040679600_bib9","doi-asserted-by":"publisher","first-page":"734210","DOI":"10.3389\/fphys.2021.734210","article-title":"RyR2 and calcium release in heart failure","volume":"12","author":"Benitah","year":"2021","journal-title":"Front. Physiol."},{"key":"2023011015040679600_bib10","first-page":"L156","article-title":"Biphasic contractile response of pulmonary artery to hypoxia","volume":"261","author":"Bennie","year":"1991","journal-title":"Am. J. Physiol."},{"key":"2023011015040679600_bib11","doi-asserted-by":"publisher","first-page":"L797","DOI":"10.1152\/ajplung.00253.2007","article-title":"Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries","volume":"294","author":"Broughton","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib12","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1113\/expphysiol.2012.065474","article-title":"The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: Vasoconstrictor and structural mechanisms contribute equally","volume":"97","author":"Cahill","year":"2012","journal-title":"Exp. Physiol."},{"key":"2023011015040679600_bib13","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ceca.2009.05.007","article-title":"Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors","volume":"46","author":"Chalmers","year":"2009","journal-title":"Cell Calcium"},{"key":"2023011015040679600_bib14","doi-asserted-by":"publisher","first-page":"5","DOI":"10.14814\/phy2.13396","article-title":"Human hypoxic pulmonary vasoconstriction is unaltered by 8\u00a0h of preceding isocapnic hyperoxia","volume":"5","author":"Cheng","year":"2017","journal-title":"Physiol. Rep."},{"key":"2023011015040679600_bib15","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1113\/jphysiol.2003.059568","article-title":"Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries","volume":"556","author":"Cheranov","year":"2004","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib16","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1161\/01.RES.0000223059.19250.91","article-title":"A calmodulin-binding site on cyclin E mediates Ca2+-sensitive G1\/s transitions in vascular smooth muscle cells","volume":"98","author":"Choi","year":"2006","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1196\/annals.1378.053","article-title":"Role of reactive oxygen species in Kv channel inhibition and vasoconstriction induced by TP receptor activation in rat pulmonary arteries","volume":"1091","author":"Cogolludo","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2023011015040679600_bib18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/14728222.2020.1708326","article-title":"Targeting pathological leak of ryanodine receptors: Preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure","volume":"24","author":"Connell","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"2023011015040679600_bib19","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.freeradbiomed.2011.12.001","article-title":"Myeloperoxidase-derived oxidants inhibit sarco\/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells","volume":"52","author":"Cook","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"2023011015040679600_bib20","doi-asserted-by":"publisher","first-page":"9596","DOI":"10.1074\/jbc.275.13.9596","article-title":"Requirement of ryanodine receptor subtypes 1 and 2 for Ca2+-induced Ca2+ release in vascular myocytes","volume":"275","author":"Coussin","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib21","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/micc.12027","article-title":"Ryanodine receptors, calcium signaling, and regulation of vascular tone in the cerebral parenchymal microcirculation","volume":"20","author":"Dabertrand","year":"2013","journal-title":"Microcirculation"},{"key":"2023011015040679600_bib22","doi-asserted-by":"publisher","first-page":"C66","DOI":"10.1152\/ajpcell.00290.2020","article-title":"PDGF\/MEK\/ERK axis represses Ca2+ clearance via decreasing the abundance of plasma membrane Ca2+ pump PMCA4 in pulmonary arterial smooth muscle cells","volume":"320","author":"Deng","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2023011015040679600_bib23","doi-asserted-by":"publisher","first-page":"11435","DOI":"10.1074\/jbc.M703875200","article-title":"Induction of hypoxia-inducible factor 1\u03b1 gene expression by vascular endothelial growth factor","volume":"283","author":"Deudero","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2147\/DMSO.S30005","article-title":"Cardiac ryanodine receptor in metabolic syndrome: Is JTV519 (K201) future therapy?","volume":"5","author":"Dincer","year":"2012","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"2023011015040679600_bib25","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41569-020-0394-8","article-title":"Intracellular calcium leak in heart failure and atrial fibrillation: A unifying mechanism and therapeutic target","volume":"17","author":"Dridi","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"2023011015040679600_bib26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1469-7793.1999.139aa.x","article-title":"Release of Ca2+ from the sarcoplasmic reticulum increases mitochondrial [Ca2+] in rat pulmonary artery smooth muscle cells","volume":"516","author":"Drummond","year":"1999","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib27","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010368","article-title":"A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c 7580T&gt;G for 6 years in a 9-year-old child","volume":"97","author":"Duan","year":"2018","journal-title":"Medicine"},{"key":"2023011015040679600_bib28","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.chest.2016.09.001","article-title":"Hypoxic pulmonary vasoconstriction: From molecular mechanisms to medicine","volume":"151","author":"Dunham-Snary","year":"2017","journal-title":"Chest"},{"key":"2023011015040679600_bib29","doi-asserted-by":"publisher","first-page":"135249","DOI":"10.1155\/2009\/135249","article-title":"Role of ryanodine receptor subtypes in initiation and formation of calcium sparks in arterial smooth muscle: Comparison with striated muscle","volume":"2009","author":"Essin","year":"2009","journal-title":"J. Biomed. Biotechnol."},{"key":"2023011015040679600_bib30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S1569-9048(02)00046-0","article-title":"Hypoxic pulmonary vasoconstriction: Cyclic adenosine diphosphate-ribose, smooth muscle Ca2+ stores and the endothelium","volume":"132","author":"Evans","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"2023011015040679600_bib31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-319-18440-1_11","article-title":"Modulation of the LKB1-AMPK signalling pathway underpins hypoxic pulmonary vasoconstriction and pulmonary hypertension","volume":"860","author":"Evans","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023011015040679600_bib32","doi-asserted-by":"publisher","first-page":"H887","DOI":"10.1152\/ajpheart.1998.275.3.H887","article-title":"Resting potentials and potassium currents during development of pulmonary artery smooth muscle cells","volume":"275","author":"Evans","year":"1998","journal-title":"Am. J. Physiol."},{"key":"2023011015040679600_bib33","doi-asserted-by":"publisher","first-page":"9324018","DOI":"10.1155\/2019\/9324018","article-title":"Crosstalk between calcium and ROS in pathophysiological conditions","volume":"2019","author":"Feno","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2023011015040679600_bib34","doi-asserted-by":"publisher","first-page":"951497","DOI":"10.1155\/2012\/951497","article-title":"Pathogenic role of store-operated and receptor-operated Ca2+ channels in pulmonary arterial hypertension","volume":"2012","author":"Fernandez","year":"2012","journal-title":"J. Signal Transduct."},{"key":"2023011015040679600_bib35","doi-asserted-by":"publisher","first-page":"C581","DOI":"10.1152\/ajpcell.00202.2014","article-title":"Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype","volume":"308","author":"Fernandez","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2023011015040679600_bib36","doi-asserted-by":"publisher","first-page":"21022","DOI":"10.1074\/jbc.M600670200","article-title":"Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol","volume":"281","author":"Fessenden","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib37","doi-asserted-by":"publisher","first-page":"28727","DOI":"10.1074\/jbc.M303821200","article-title":"Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol","volume":"278","author":"Fessenden","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.biocel.2014.08.012","article-title":"Mitochondria: Roles in pulmonary hypertension","volume":"55","author":"Freund-Michel","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2023011015040679600_bib39","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: A new therapeutic target?","volume":"109","author":"Frey","year":"2004","journal-title":"Circulation"},{"key":"2023011015040679600_bib40","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1097\/00005344-200012000-00011","article-title":"Endothelin-1-induced contraction of mesenteric small arteries is mediated by ryanodine receptor Ca2+ channels and cyclic ADP-ribose","volume":"36","author":"Giulumian","year":"2000","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2023011015040679600_bib41","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1080\/19336950.2017.1344799","article-title":"FK506-binding proteins 12 and 12.6 (FKBPs) as regulators of cardiac ryanodine receptors: Insights from new functional and structural knowledge","volume":"11","author":"Gonano","year":"2017","journal-title":"Channels"},{"key":"2023011015040679600_bib42","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1113\/jphysiol.2001.015966","article-title":"Crosstalk between ryanodine receptors and IP3 receptors as a factor shaping spontaneous Ca2+-release events in rabbit portal vein myocytes","volume":"542","author":"Gordienko","year":"2002","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib43","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1074\/jbc.M311459200","article-title":"Preservation of base-line hemodynamic function and loss of inducible cardioprotection in adult mice lacking protein kinase C epsilon","volume":"279","author":"Gray","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1469-7793.1997.053bc.x","article-title":"Modulation of Ca2+-activated Cl\u2212 currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake","volume":"505","author":"Greenwood","year":"1997","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib45","doi-asserted-by":"publisher","first-page":"H77","DOI":"10.1152\/ajpheart.01355.2007","article-title":"A novel signaling pathway of ADP-ribosyl cyclase activation by angiotensin II in adult rat cardiomyocytes","volume":"295","author":"Gul","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023011015040679600_bib46","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15011","article-title":"The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes","volume":"9","author":"Guo","year":"2021","journal-title":"Physiol. Rep."},{"key":"2023011015040679600_bib47","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1054\/ceca.2000.0124","article-title":"Calcium signalling in sarcoplasmic reticulum, cytoplasm and mitochondria during activation of rabbit aorta myocytes","volume":"27","author":"Gurney","year":"2000","journal-title":"Cell Calcium"},{"key":"2023011015040679600_bib48","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1161\/01.RES.0000099883.68414.61","article-title":"Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells","volume":"93","author":"Gurney","year":"2003","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib49","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.cmet.2005.05.001","article-title":"Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing","volume":"1","author":"Guzy","year":"2005","journal-title":"Cell Metab."},{"key":"2023011015040679600_bib50","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ejphar.2006.10.005","article-title":"K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization","volume":"555","author":"Hasumi","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"2023011015040679600_bib51","doi-asserted-by":"publisher","first-page":"C166","DOI":"10.1152\/ajpcell.00159.2017","article-title":"RhoA increases ASIC1a plasma membrane localization and calcium influx in pulmonary arterial smooth muscle cells following chronic hypoxia","volume":"314","author":"Herbert","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2023011015040679600_bib52","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1164\/rccm.201604-0814OC","article-title":"MicroRNA-138 and microRNA-25 down-regulate mitochondrial calcium uniporter, causing the pulmonary arterial hypertension cancer phenotype","volume":"195","author":"Hong","year":"2017","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023011015040679600_bib53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/cvr\/cvt105","article-title":"Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: Effects of synthetic selective NF-kB inhibitor IMD-0354","volume":"99","author":"Hosokawa","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"2023011015040679600_bib54","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1113\/JP275857","article-title":"Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension","volume":"597","author":"Hu","year":"2019","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib55","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1161\/HYPERTENSIONAHA.120.15561","article-title":"Oxidation of ryanodine receptors promotes Ca2+ leakage and contributes to right ventricular dysfunction in pulmonary hypertension","volume":"77","author":"Huang","year":"2021","journal-title":"Hypertension"},{"key":"2023011015040679600_bib56","doi-asserted-by":"publisher","first-page":"2045894020956592","DOI":"10.1177\/2045894020956592","article-title":"Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused\/ventilated mouse lung","volume":"10","author":"Jain","year":"2020","journal-title":"Pulm. Circ."},{"key":"2023011015040679600_bib57","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cardiores.2007.08.013","article-title":"Inhibition of SR Ca2+ uptake: A novel action of the RyR2-FKBP12.6 antagonist K201","volume":"76","author":"James","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"2023011015040679600_bib58","doi-asserted-by":"publisher","first-page":"L271","DOI":"10.1152\/ajplung.00020.2009","article-title":"ASIC1 contributes to pulmonary vascular smooth muscle store-operated Ca2+ entry","volume":"297","author":"Jernigan","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib59","doi-asserted-by":"publisher","first-page":"L801","DOI":"10.1152\/ajplung.00443.2003","article-title":"Endothelium-derived reactive oxygen species and endothelin-1 attenuate NO-dependent pulmonary vasodilation following chronic hypoxia","volume":"287","author":"Jernigan","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib60","doi-asserted-by":"publisher","first-page":"L515","DOI":"10.1152\/ajplung.00355.2007","article-title":"Reactive oxygen species mediate RhoA\/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia","volume":"295","author":"Jernigan","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib61","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/ddr.430330406","article-title":"New 1,4-benzothiazepine derivative, K201, demonstrates cardioprotective effects against sudden cardiac cell death andintracellular calcium blocking action","volume":"33","author":"Kaneko","year":"1994","journal-title":"Drug Dev. Res."},{"key":"2023011015040679600_bib62","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2174\/157488409788184972","article-title":"Pharmacological characteristics and clinical applications of K201","volume":"4","author":"Kaneko","year":"2009","journal-title":"Curr. Clin. Pharmacol."},{"key":"2023011015040679600_bib63","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1016\/j.bbagen.2012.12.015","article-title":"Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1\/2 and NF-\u03baB activation in vascular smooth muscle cells","volume":"1830","author":"Karki","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2023011015040679600_bib64","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010090","article-title":"Role of ryanodine type 2 receptors in elementary Ca2+ signaling in arteries and vascular adaptive responses","volume":"8","author":"Ka\u00dfmann","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"2023011015040679600_bib65","doi-asserted-by":"publisher","first-page":"431","DOI":"10.4196\/kjpp.2011.15.6.431","article-title":"Alteration of ryanodine-receptors in cultured rat aortic smooth muscle cells","volume":"15","author":"Kim","year":"2011","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"2023011015040679600_bib66","doi-asserted-by":"publisher","first-page":"L368","DOI":"10.1152\/ajplung.00253.2014","article-title":"Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia","volume":"308","author":"Kim","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib67","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1254\/jjp.79.275","article-title":"Effects of a novel cardioprotective drug, JTV-519, on membrane currents of guinea pig ventricular myocytes","volume":"79","author":"Kimura","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"key":"2023011015040679600_bib68","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s002100000230","article-title":"Effects of JTV-519, a novel anti-ischaemic drug, on the delayed rectifier K+ current in guinea-pig ventricular myocytes","volume":"361","author":"Kiriyama","year":"2000","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"2023011015040679600_bib69","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S1097-2765(00)00041-1","article-title":"Gating of store-operated channels by conformational coupling to ryanodine receptors","volume":"6","author":"Kiselyov","year":"2000","journal-title":"Mol. Cell"},{"key":"2023011015040679600_bib70","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/ijms221910795","article-title":"The ryanodine receptor as a sensor for intracellular environments in muscles","volume":"22","author":"Kobayashi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023011015040679600_bib71","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.freeradbiomed.2011.01.010","article-title":"Primary role of mitochondrial Rieske iron-sulfur protein in hypoxic ROS production in pulmonary artery myocytes","volume":"50","author":"Korde","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"2023011015040679600_bib72","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0079-6107(03)00056-7","article-title":"Calcium-induced calcium release in smooth muscle: The case for loose coupling","volume":"83","author":"Kotlikoff","year":"2003","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"2023011015040679600_bib73","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1469-7793.2001.00211.x","article-title":"Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: Identity of the hypoxic sensor","volume":"536","author":"Leach","year":"2001","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib74","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1165\/rcmb.2014-0141OC","article-title":"CD38 mediates angiotensin II-induced intracellular Ca2+ release in rat pulmonary arterial smooth muscle cells","volume":"52","author":"Lee","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023011015040679600_bib75","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1172\/JCI35346","article-title":"Leaky Ca2+ release channel\/ryanodine receptor 2 causes seizures and sudden cardiac death in mice","volume":"118","author":"Lehnart","year":"2008","journal-title":"J. Clin. Invest."},{"key":"2023011015040679600_bib76","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1161\/HYPERTENSIONAHA.114.03220","article-title":"Inhibition of nuclear factor-\u03baB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice","volume":"63","author":"Li","year":"2014","journal-title":"Hypertension"},{"key":"2023011015040679600_bib77","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1166\/msr.2013.1022","article-title":"Cyclic ADP-ribose and NAADP in vascular regulation and diseases","volume":"2","author":"Li","year":"2013","journal-title":"Messenger"},{"key":"2023011015040679600_bib78","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s00424-008-0556-8","article-title":"Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells","volume":"457","author":"Li","year":"2009","journal-title":"Pflugers Arch."},{"key":"2023011015040679600_bib79","doi-asserted-by":"publisher","first-page":"119016","DOI":"10.1016\/j.lfs.2021.119016","article-title":"Diversity of ryanodine receptor 1-mediated Ca2+ signaling in systemic and pulmonary artery smooth muscle cells","volume":"270","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"2023011015040679600_bib80","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/biomedicines10020341","article-title":"Mitochondrial metabolism, redox, and calcium homeostasis in pulmonary arterial hypertension","volume":"10","author":"Liang","year":"2022","journal-title":"Biomedicines"},{"key":"2023011015040679600_bib81","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/ars.2009.3047","article-title":"Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes","volume":"14","author":"Liao","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"2023011015040679600_bib82","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1093\/cvr\/cvw067","article-title":"Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes","volume":"111","author":"Lin","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"2023011015040679600_bib83","doi-asserted-by":"publisher","first-page":"H1321","DOI":"10.1152\/ajpheart.00795.2002","article-title":"Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction","volume":"284","author":"Littler","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023011015040679600_bib84","doi-asserted-by":"publisher","first-page":"L322","DOI":"10.1152\/ajplung.00337.2002","article-title":"Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries","volume":"285","author":"Liu","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib85","doi-asserted-by":"publisher","first-page":"L2","DOI":"10.1152\/ajplung.00135.2005","article-title":"Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidase (gp91phox)","volume":"290","author":"Liu","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib86","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.1073\/pnas.0813307106","article-title":"Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle","volume":"106","author":"Liu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023011015040679600_bib87","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1161\/01.RES.77.3.638","article-title":"Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5\u2032 enhancer","volume":"77","author":"Liu","year":"1995","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib88","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1242\/jcs.064071","article-title":"Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor","volume":"123","author":"Liu","year":"2010","journal-title":"J. Cell Sci."},{"key":"2023011015040679600_bib89","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1161\/hh2301.100250","article-title":"Regulation of calcium sparks and spontaneous transient outward currents by RyR3 in arterial vascular smooth muscle cells","volume":"89","author":"L\u00f6hn","year":"2001","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib90","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1152\/japplphysiol.01383.2010","article-title":"Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes","volume":"111","author":"Lunde","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"2023011015040679600_bib91","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1086\/674770","article-title":"A comprehensive review: The evolution of animal models in pulmonary hypertension research; are we there yet?","volume":"3","author":"Maarman","year":"2013","journal-title":"Pulm. Circ."},{"key":"2023011015040679600_bib92","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-3-030-68748-9_2","article-title":"Cellular and molecular processes in pulmonary hypertension","volume":"1304","author":"Maietta","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023011015040679600_bib93","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1124\/jpet.109.160119","article-title":"Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats","volume":"332","author":"Mam","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023011015040679600_bib94","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.mayocp.2020.04.039","article-title":"Pulmonary hypertension: A brief guide for clinicians","volume":"95","author":"Mandras","year":"2020","journal-title":"Mayo Clin. Proc."},{"key":"2023011015040679600_bib95","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0024-3205(98)00393-2","article-title":"Mechanisms involved in the cellular calcium homeostasis in vascular smooth muscle: Calcium pumps","volume":"64","author":"Mar\u00edn","year":"1999","journal-title":"Life Sci."},{"key":"2023011015040679600_bib96","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1165\/ajrcmb.15.5.8918370","article-title":"Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction","volume":"15","author":"Marshall","year":"1996","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023011015040679600_bib97","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00424-012-1108-9","article-title":"Mitochondrial regulation of cytosolic Ca\u00b2\u207a signals in smooth muscle","volume":"464","author":"McCarron","year":"2012","journal-title":"Pflugers Arch."},{"key":"2023011015040679600_bib98","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/micc.12039","article-title":"Examining the role of mitochondria in Ca\u00b2\u207a signaling in native vascular smooth muscle","volume":"20","author":"McCarron","year":"2013","journal-title":"Microcirculation"},{"key":"2023011015040679600_bib99","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1113\/jphysiol.1996.sp021771","article-title":"The temporal profile of calcium transients in voltage clamped gastric myocytes from Bufo marinus","volume":"497","author":"McGeown","year":"1996","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib100","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1378\/chest.07-2984","article-title":"Generation of oxidants by hypoxic human pulmonary and coronary smooth-muscle cells","volume":"133","author":"Mehta","year":"2008","journal-title":"Chest"},{"key":"2023011015040679600_bib101","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1038\/s41467-020-17314-1","article-title":"Rieske iron-sulfur protein induces FKBP12.6\/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-\u03baB\/cyclin D1 pathway","volume":"11","author":"Mei","year":"2020","journal-title":"Nat. Commun."},{"key":"2023011015040679600_bib102","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054208","article-title":"Stabilization of the skeletal muscle ryanodine receptor ion channel-FKBP12 complex by the 1,4-benzothiazepine derivative S107","volume":"8","author":"Mei","year":"2013","journal-title":"PLoS One"},{"key":"2023011015040679600_bib103","first-page":"361","article-title":"Acute hypoxic pulmonary vasoconstriction: A model of oxygen sensing","volume":"44","author":"Michelakis","year":"1995","journal-title":"Physiol. Res."},{"key":"2023011015040679600_bib104","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1161\/hc0202.101974","article-title":"Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: Role of increased expression and activity of voltage-gated potassium channels","volume":"105","author":"Michelakis","year":"2002","journal-title":"Circulation"},{"key":"2023011015040679600_bib105","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/sj.bjp.0703713","article-title":"Inhibitory effects of JTV-519, a novel cardioprotective drug, on potassium currents and experimental atrial fibrillation in guinea-pig hearts","volume":"131","author":"Nakaya","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"2023011015040679600_bib106","doi-asserted-by":"publisher","first-page":"C313","DOI":"10.1152\/ajpcell.00258.2007","article-title":"Cell culture alters Ca2+ entry pathways activated by store-depletion or hypoxia in canine pulmonary arterial smooth muscle cells","volume":"294","author":"Ng","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2023011015040679600_bib107","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1113\/jphysiol.2004.078311","article-title":"Mobilization of sarcoplasmic reticulum stores by hypoxia leads to consequent activation of capacitative Ca2+ entry in isolated canine pulmonary arterial smooth muscle cells","volume":"563","author":"Ng","year":"2005","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib108","doi-asserted-by":"publisher","first-page":"172777","DOI":"10.1016\/j.ejphar.2019.172777","article-title":"Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor","volume":"865","author":"Novelli","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"2023011015040679600_bib109","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.yjmcc.2015.06.009","article-title":"Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity","volume":"85","author":"Oda","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023011015040679600_bib110","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.1161\/CIRCULATIONAHA.104.507921","article-title":"Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure","volume":"111","author":"Oda","year":"2005","journal-title":"Circulation"},{"key":"2023011015040679600_bib111","doi-asserted-by":"publisher","first-page":"L15","DOI":"10.1152\/ajplung.00372.2002","article-title":"Opposite effects of redox status on membrane potential, cytosolic calcium, and tone in pulmonary arteries and ductus arteriosus","volume":"286","author":"Olschewski","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib112","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.RES.0000219677.12988.e9","article-title":"Impact of TASK-1 in human pulmonary artery smooth muscle cells","volume":"98","author":"Olschewski","year":"2006","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib113","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1038\/sj.bjp.0702006","article-title":"Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle","volume":"124","author":"Osipenko","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"2023011015040679600_bib114","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1161\/01.RES.86.5.534","article-title":"Potential role for kv3.1b channels as oxygen sensors","volume":"86","author":"Osipenko","year":"2000","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib115","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/1074248412465489","article-title":"Protective effect of K201 on isoproterenol-induced and ischemic-reperfusion-induced ventricular arrhythmias in the rat: Comparison with diltiazem","volume":"18","author":"Otani","year":"2013","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"2023011015040679600_bib116","doi-asserted-by":"publisher","first-page":"800965","DOI":"10.1183\/13993003.00965-2018","article-title":"Targeting TMEM16A to reverse vasoconstriction and remodelling in\u00a0idiopathic pulmonary arterial hypertension","volume":"53","author":"Papp","year":"2019","journal-title":"Eur. Respir. J."},{"key":"2023011015040679600_bib117","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.biocel.2017.09.022","article-title":"Hypoxia-induced activation of specific members of the NF-kB family and its relevance to pulmonary vascular remodeling","volume":"92","author":"Patel","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2023011015040679600_bib118","first-page":"605","article-title":"Acute hypoxia activates store-operated Ca2+ entry and increases intracellular Ca2+ concentration in rat distal pulmonary venous smooth muscle cells","volume":"5","author":"Peng","year":"2013","journal-title":"J. Thorac. Dis."},{"key":"2023011015040679600_bib119","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00424-010-0850-0","article-title":"Modulation of Ca2+ release through ryanodine receptors in vascular smooth muscle by protein kinase Calpha","volume":"460","author":"Peng","year":"2010","journal-title":"Pflugers Arch."},{"key":"2023011015040679600_bib120","doi-asserted-by":"publisher","first-page":"625763","DOI":"10.3389\/fmed.2021.625763","article-title":"Novel TNIP2 and TRAF2 variants are implicated in the pathogenesis of pulmonary arterial hypertension","volume":"8","author":"Pienkos","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"2023011015040679600_bib121","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1161\/01.RES.77.1.131","article-title":"[Ca2+]i inhibition of K+ channels in canine pulmonary artery. Novel mechanism for hypoxia-induced membrane depolarization","volume":"77","author":"Post","year":"1995","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib122","doi-asserted-by":"publisher","first-page":"C882","DOI":"10.1152\/ajpcell.1992.262.4.C882","article-title":"Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction","volume":"262","author":"Post","year":"1992","journal-title":"Am. J. Physiol."},{"key":"2023011015040679600_bib123","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/cphy.c100054","article-title":"Reactive oxygen species: Impact on skeletal muscle","volume":"1","author":"Powers","year":"2011","journal-title":"Compr. Physiol."},{"key":"2023011015040679600_bib124","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1055\/s-0039-1687818","article-title":"AGE-RAGE stress in the pathophysiology of pulmonary hypertension and its treatment","volume":"28","author":"Prasad","year":"2019","journal-title":"Int. J. Angiol."},{"key":"2023011015040679600_bib125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075415","article-title":"Nuclear factor \u03ba-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension","volume":"8","author":"Price","year":"2013","journal-title":"PLoS One"},{"key":"2023011015040679600_bib126","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1378\/chest.11-0793","article-title":"Inflammation in pulmonary arterial hypertension","volume":"141","author":"Price","year":"2012","journal-title":"Chest"},{"key":"2023011015040679600_bib127","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1161\/01.CIR.103.2.196","article-title":"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia","volume":"103","author":"Priori","year":"2001","journal-title":"Circulation"},{"key":"2023011015040679600_bib128","doi-asserted-by":"publisher","first-page":"21874","DOI":"10.1073\/pnas.1911304116","article-title":"Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility","volume":"116","author":"Pritchard","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023011015040679600_bib129","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/SHK.0000000000001606","article-title":"Overexpressed lncRNA AC068039.4 contributes to proliferation and cell cycle progression of pulmonary artery smooth muscle cells via sponging miR-26a-5p\/TRPC6 in hypoxic pulmonary arterial hypertension","volume":"55","author":"Qin","year":"2021","journal-title":"Shock"},{"key":"2023011015040679600_bib130","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1165\/rcmb.2011-0128OC","article-title":"Hypoxia-induced pulmonary arterial smooth muscle cell proliferation is controlled by forkhead box M1","volume":"46","author":"Raghavan","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023011015040679600_bib131","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1002\/1531-8249(200011)48:5&lt;774::AID-ANA11&gt;3.0.CO;2-I","article-title":"An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production","volume":"48","author":"Rana","year":"2000","journal-title":"Ann. Neurol."},{"key":"2023011015040679600_bib132","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.bbrc.2006.10.116","article-title":"Mitochondrial ROS-PKCepsilon signaling axis is uniquely involved in hypoxic increase in [Ca2+]i in pulmonary artery smooth muscle cells","volume":"351","author":"Rathore","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023011015040679600_bib133","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.freeradbiomed.2008.06.012","article-title":"Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKC\u03b5 signaling axis in pulmonary artery smooth muscle cells","volume":"45","author":"Rathore","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"2023011015040679600_bib134","doi-asserted-by":"publisher","first-page":"174692","DOI":"10.1016\/j.ejphar.2021.174692","article-title":"Transient receptor potential cation channel subfamily V (TRPV) and its importance in asthma","volume":"915","author":"Reyes-Garc\u00eda","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"2023011015040679600_bib135","doi-asserted-by":"publisher","first-page":"2998","DOI":"10.3892\/ijmm.2018.3910","article-title":"Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)","volume":"42","author":"Reyes-Garc\u00eda","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"2023011015040679600_bib136","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/978-3-030-68748-9_15","article-title":"Sex hormones and lung inflammation","volume":"1304","author":"Reyes-Garc\u00eda","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023011015040679600_bib137","doi-asserted-by":"publisher","first-page":"486","DOI":"10.3389\/fphys.2018.00486","article-title":"Revisiting the role of TRP, Orai, and ASIC channels in the pulmonary arterial response to hypoxia","volume":"9","author":"Reyes","year":"2018","journal-title":"Front. Physiol."},{"key":"2023011015040679600_bib138","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1179\/174329210X12650506623401","article-title":"Nox isoforms in vascular pathophysiology: Insights from transgenic and knockout mouse models","volume":"15","author":"Rivera","year":"2010","journal-title":"Redox Rep."},{"key":"2023011015040679600_bib139","first-page":"H301","article-title":"Hypoxic vasoconstriction and intracellular Ca2+ in pulmonary arteries: Evidence for PKC-independent Ca2+ sensitization","volume":"268","author":"Robertson","year":"1995","journal-title":"Am. J. Physiol."},{"key":"2023011015040679600_bib140","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/CIRCRESAHA.113.301129","article-title":"The right ventricle in pulmonary arterial hypertension: Disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure","volume":"115","author":"Ryan","year":"2014","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib141","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/cells9102197","article-title":"Hypoxia promotes mitochondrial complex I abundance via HIF-1\u03b1 in complex III and complex IV eficient cells","volume":"9","author":"Saldana-Caboverde","year":"2020","journal-title":"Cells"},{"key":"2023011015040679600_bib142","doi-asserted-by":"publisher","first-page":"24804","DOI":"10.1074\/jbc.M501487200","article-title":"The foot structure from the type 1 ryanodine receptor is required for functional coupling to store-operated channels","volume":"280","author":"Sampieri","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib143","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3181\/0712-RM-337","article-title":"Role of oxidative stress and NFkB in hypoxia-induced pulmonary edema","volume":"233","author":"Sarada","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"2023011015040679600_bib144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164795","article-title":"Patient-specific human induced pluripotent stem cell model assessed with electrical pacing validates S107 as a potential therapeutic agent for catecholaminergic polymorphic ventricular tachycardia","volume":"11","author":"Sasaki","year":"2016","journal-title":"PLoS One"},{"key":"2023011015040679600_bib145","doi-asserted-by":"publisher","first-page":"L48","DOI":"10.1152\/ajplung.00362.2013","article-title":"Role of Kv7 channels in responses of the pulmonary circulation to hypoxia","volume":"308","author":"Sedivy","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib146","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1042\/BJ20051214","article-title":"Quantitative mapping of oxidation-sensitive cysteine residues in SERCA in vivo and in vitro by HPLC-electrospray-tandem MS: Selective protein oxidation during biological aging","volume":"394","author":"Sharov","year":"2006","journal-title":"Biochem. J."},{"key":"2023011015040679600_bib147","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2023011015040679600_bib148","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.chest.2019.04.111","article-title":"Pulmonary vascular distensibility and early pulmonary vascular remodeling in pulmonary hypertension","volume":"156","author":"Singh","year":"2019","journal-title":"Chest"},{"key":"2023011015040679600_bib149","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1113\/JP275852","article-title":"Sensors and signals: The role of reactive oxygen species in hypoxic pulmonary vasoconstriction","volume":"597","author":"Smith","year":"2019","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib150","doi-asserted-by":"publisher","first-page":"L1455","DOI":"10.1152\/ajplung.00148.2015","article-title":"Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells","volume":"309","author":"Song","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib151","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/978-3-319-63245-2_17","article-title":"Cross talk between mitochondrial reactive oxygen species and sarcoplasmic reticulum calcium in pulmonary arterial smooth muscle cells","volume":"967","author":"Song","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023011015040679600_bib152","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1113\/jphysiol.2012.232520","article-title":"Chronic hypoxia-induced upregulation of Ca2+-activated Cl\u2212 channel in pulmonary arterial myocytes: A mechanism contributing to enhanced vasoreactivity","volume":"590","author":"Sun","year":"2012","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib153","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.hrthm.2022.02.003","article-title":"Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension","volume":"19","author":"Tanaka","year":"2022","journal-title":"Heart Rhythm"},{"key":"2023011015040679600_bib154","doi-asserted-by":"publisher","first-page":"H1304","DOI":"10.1152\/ajpheart.00843.2001","article-title":"Role of FKBP12.6 in cADPR-induced activation of reconstituted ryanodine receptors from arterial smooth muscle","volume":"282","author":"Tang","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023011015040679600_bib155","doi-asserted-by":"publisher","first-page":"H707","DOI":"10.1152\/ajpheart.00564.2014","article-title":"Long-term hypoxia increases calcium affinity of BK channels in ovine fetal and adult cerebral artery smooth muscle","volume":"308","author":"Tao","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2023011015040679600_bib156","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1152\/physrev.00036.2017","article-title":"Sources of vascular nitric oxide and reactive oxygen species and their regulation","volume":"99","author":"Tejero","year":"2019","journal-title":"Physiol. Rev."},{"key":"2023011015040679600_bib157","doi-asserted-by":"publisher","first-page":"767002","DOI":"10.3389\/fphar.2021.767002","article-title":"Therapy for pulmonary arterial hypertension: Glance on nitric oxide pathway","volume":"12","author":"Tettey","year":"2021","journal-title":"Front. Pharmacol."},{"key":"2023011015040679600_bib158","doi-asserted-by":"publisher","first-page":"F360","DOI":"10.1152\/ajprenal.00512.2007","article-title":"ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo","volume":"295","author":"Thai","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"2023011015040679600_bib159","doi-asserted-by":"publisher","first-page":"37233","DOI":"10.1074\/jbc.M112.398974","article-title":"Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes","volume":"287","author":"Thakur","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2023011015040679600_bib160","doi-asserted-by":"publisher","first-page":"9367673","DOI":"10.1155\/2020\/9367673","article-title":"Endothelin-1 downregulates sulfur dioxide\/aspartate aminotransferase pathway via reactive oxygen species to promote the proliferation and migration of vascular smooth muscle cells","volume":"2020","author":"Tian","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2023011015040679600_bib161","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/hmg\/10.3.189","article-title":"Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2)","volume":"10","author":"Tiso","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"2023011015040679600_bib162","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00395-009-0057-8","article-title":"K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum","volume":"105","author":"Toischer","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"2023011015040679600_bib163","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.1113\/jphysiol.2012.233353","article-title":"STIM\/Orai signalling complexes in vascular smooth muscle","volume":"590","author":"Trebak","year":"2012","journal-title":"J. Physiol."},{"key":"2023011015040679600_bib164","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-3-030-68748-9_9","article-title":"Overview on interactive role of inflammation, reactive oxygen species, and calcium signaling in asthma, COPD, and pulmonary hypertension","volume":"1304","author":"Truong","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"2023011015040679600_bib165","doi-asserted-by":"publisher","first-page":"108234","DOI":"10.1016\/j.abb.2019.108234","article-title":"Mitochondrial Rieske iron-sulfur protein in pulmonary artery smooth muscle: A key primary signaling molecule in pulmonary hypertension","volume":"683","author":"Truong","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"2023011015040679600_bib166","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/0003-9861(85)90293-0","article-title":"Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria","volume":"237","author":"Turrens","year":"1985","journal-title":"Arch. Biochem. Biophys."},{"key":"2023011015040679600_bib167","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ceca.2007.04.010","article-title":"Metabotropic Ca2+ channel-induced calcium release in vascular smooth muscle","volume":"42","author":"Ure\u00f1a","year":"2007","journal-title":"Cell Calcium"},{"key":"2023011015040679600_bib168","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1089\/ars.2019.7742","article-title":"Redox imbalance in idiopathic pulmonary fibrosis: A role for oxidant cross-talk between NADPH oxidase enzymes and mitochondria","volume":"31","author":"Veith","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"2023011015040679600_bib169","first-page":"1186","article-title":"Mechanisms of hypoxic pulmonary vasoconstriction","volume":"133","author":"Voelkel","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"2023011015040679600_bib170","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1172\/JCI11144","article-title":"Hypoxia-induced pulmonary vascular remodeling: A model for what human disease?","volume":"106","author":"Voelkel","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2023011015040679600_bib171","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fmed.2016.00023","article-title":"Pulmonary hypertension and indicators of right ventricular function","volume":"3","author":"von Siebenthal","year":"2016","journal-title":"Front. Med."},{"key":"2023011015040679600_bib172","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1465-9921-10-123","article-title":"Inhibition of SOC\/Ca2+\/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells","volume":"10","author":"Wang","year":"2009","journal-title":"Respir. Res."},{"key":"2023011015040679600_bib173","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1161\/01.RES.0000227551.68124.98","article-title":"Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca2+ in pulmonary arterial smooth muscle cells","volume":"98","author":"Wang","year":"2006","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib174","doi-asserted-by":"publisher","first-page":"17074","DOI":"10.1038\/cddiscovery.2017.74","article-title":"Orai1, 2, 3 and STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells","volume":"3","author":"Wang","year":"2017","journal-title":"Cell Death Discov."},{"key":"2023011015040679600_bib175","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.3892\/mmr.2015.4750","article-title":"TRPC6 is required for hypoxia-induced basal intracellular calcium concentration elevation, and for the proliferation and migration of rat distal pulmonary venous smooth muscle cells","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"2023011015040679600_bib176","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.freeradbiomed.2006.12.008","article-title":"Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes","volume":"42","author":"Wang","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"2023011015040679600_bib177","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.taap.2019.02.017","article-title":"Inhibition of RhoA\/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1\u03b1-dependent functional TRPC channels","volume":"369","author":"Wang","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2023011015040679600_bib178","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.freeradbiomed.2008.08.015","article-title":"A twist in the tail: Synergism between mitochondria and NADPH oxidase in the hypoxia-induced elevation of reactive oxygen species in pulmonary artery","volume":"45","author":"Ward","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"2023011015040679600_bib179","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/hh1201.091960","article-title":"Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing","volume":"88","author":"Waypa","year":"2001","journal-title":"Circ. Res."},{"key":"2023011015040679600_bib180","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1164\/rccm.201207-1294OC","article-title":"Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation","volume":"187","author":"Waypa","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023011015040679600_bib181","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/9780470035009.ch14","article-title":"Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction","volume":"272","author":"Waypa","year":"2006","journal-title":"Novartis Found Symp."},{"key":"2023011015040679600_bib182","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1126\/science.1094301","article-title":"Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2","volume":"304","author":"Wehrens","year":"2004","journal-title":"Science"},{"key":"2023011015040679600_bib183","doi-asserted-by":"publisher","first-page":"58","DOI":"10.4331\/wjbc.v5.i1.58","article-title":"Roles and mechanisms of the CD38\/cyclic adenosine diphosphate ribose\/Ca2+ signaling pathway","volume":"5","author":"Wei","year":"2014","journal-title":"World J. Biol. Chem."},{"key":"2023011015040679600_bib184","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cardiores.2006.04.014","article-title":"Role of ion channels in acute and chronic responses of the pulmonary vasculature to hypoxia","volume":"71","author":"Weir","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"2023011015040679600_bib185","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.resp.2003.10.003","article-title":"Basic features of hypoxic pulmonary vasoconstriction in mice","volume":"139","author":"Weissmann","year":"2004","journal-title":"Respir. Physiol. Neurobiol."},{"key":"2023011015040679600_bib186","doi-asserted-by":"publisher","first-page":"19093","DOI":"10.1073\/pnas.0606728103","article-title":"Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange","volume":"103","author":"Weissmann","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023011015040679600_bib187","doi-asserted-by":"publisher","first-page":"L683","DOI":"10.1152\/ajplung.2000.279.4.L683","article-title":"Hypoxic vasoconstriction in intact lungs: A role for NADPH oxidase-derived H2O2?","volume":"279","author":"Weissmann","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib188","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1165\/rcmb.2005-0337OC","article-title":"Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction","volume":"34","author":"Weissmann","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2023011015040679600_bib189","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1111\/jcmm.13645","article-title":"FKBP12.6 protects heart from AngII-induced hypertrophy through inhibiting Ca2+\/calmodulin-mediated signalling pathways in vivo and in vitro","volume":"22","author":"Xiao","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"2023011015040679600_bib190","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/416334a","article-title":"Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy","volume":"416","author":"Xin","year":"2002","journal-title":"Nature"},{"key":"2023011015040679600_bib191","doi-asserted-by":"publisher","first-page":"L143","DOI":"10.1152\/ajplung.00310.2012","article-title":"Important role of PLC-\u03b31 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells","volume":"304","author":"Yadav","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib192","doi-asserted-by":"publisher","first-page":"L724","DOI":"10.1152\/ajplung.00243.2017","article-title":"PLC\u03b31-PKC\u03b5-IP3R1 signaling plays an important role in hypoxia-induced calcium response in pulmonary artery smooth muscle cells","volume":"314","author":"Yadav","year":"2018","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib193","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1136\/jim-2020-001291","article-title":"Clinical update on pulmonary hypertension","volume":"68","author":"Yaghi","year":"2020","journal-title":"J. Investig. Med."},{"key":"2023011015040679600_bib194","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1161\/CIRCULATIONAHA.107.718957","article-title":"Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts","volume":"117","author":"Yamamoto","year":"2008","journal-title":"Circulation"},{"key":"2023011015040679600_bib195","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1089\/ars.2018.7652","article-title":"Important role of sarcoplasmic reticulum Ca2+ release ryanodine receptor-2 channel in hypoxia-induced Rieske iron-sulfur protein-mediated mitochondrial reactive oxygen species generation in pulmonary artery smooth muscle cells","volume":"32","author":"Yang","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"2023011015040679600_bib196","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fmed.2019.00093","article-title":"Thin air, thick vessels: Historical and current perspectives on hypoxic pulmonary hypertension","volume":"6","author":"Young","year":"2019","journal-title":"Front. Med."},{"key":"2023011015040679600_bib197","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.mvr.2010.03.002","article-title":"Plasmid-based short hairpin RNA against cyclin D1 attenuated pulmonary vascular remodeling in smoking rats","volume":"80","author":"Zeng","year":"2010","journal-title":"Microvasc. Res."},{"key":"2023011015040679600_bib198","doi-asserted-by":"publisher","first-page":"L603","DOI":"10.1152\/ajplung.1997.273.3.L603","article-title":"Pulmonary artery smooth muscle cell [Ca2+]i and contraction: Responses to diphenyleneiodonium and hypoxia","volume":"273","author":"Zhang","year":"1997","journal-title":"Am. J. Physiol."},{"key":"2023011015040679600_bib199","doi-asserted-by":"publisher","first-page":"L680","DOI":"10.1152\/ajplung.00067.2003","article-title":"ET-1 activates Ca2+ sparks in PASMC: Local Ca2+ signaling between inositol trisphosphate and ryanodine receptors","volume":"285","author":"Zhang","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023011015040679600_bib200","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1093\/cvr\/cvaa163","article-title":"Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts","volume":"117","author":"Zhang","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"2023011015040679600_bib201","first-page":"563","article-title":"Endothelin-1 promoted proliferation of vascular smooth muscle cell through pathway of extracellular signal-regulated kinase and cyclin D1","volume":"24","author":"Zhang","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"2023011015040679600_bib202","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.7150\/ijbs.21475","article-title":"Distinct effects of Ca2+ sparks on cerebral artery and airway smooth muscle cell tone in mice and humans","volume":"13","author":"Zhao","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"2023011015040679600_bib203","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.ceca.2003.09.006","article-title":"Role of FKBP12.6 in hypoxia- and norepinephrine-induced Ca2+ release and contraction in pulmonary artery myocytes","volume":"35","author":"Zheng","year":"2004","journal-title":"Cell Calcium"},{"key":"2023011015040679600_bib204","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1159\/000127438","article-title":"Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells","volume":"45","author":"Zheng","year":"2008","journal-title":"J. Vasc. Res."},{"key":"2023011015040679600_bib205","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1085\/jgp.200409232","article-title":"Type-3 ryanodine receptors mediate hypoxia-, but not neurotransmitter-induced calcium release and contraction in pulmonary artery smooth muscle cells","volume":"125","author":"Zheng","year":"2005","journal-title":"J. Gen. Physiol."}],"container-title":["Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/doi\/10.1085\/jgp.202213100\/1446389\/jgp_202213100.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/doi\/10.1085\/jgp.202213100\/1446389\/jgp_202213100.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:05:46Z","timestamp":1673363146000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/155\/3\/e202213100\/213798\/Role-of-ryanodine-receptor-2-and-FK506-binding"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,16]]},"references-count":205,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,6]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.202213100","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,16]]},"article-number":"e202213100"}}