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Here, we studied the functional contribution of Nav1.8 in DRG neurons using a dynamic clamp to express Nav1.7L848H, a gain-of-function Nav1.7 mutation that causes inherited erythromelalgia (IEM), a human genetic model of neuropathic pain, and demonstrate a profound functional interaction of Nav1.8 with Nav1.7 close to the threshold for AP generation. At the voltage threshold of \u221221.9 mV, we observed that Nav1.8 channel open-probability exceeded Nav1.7WT channel open-probability ninefold. Using a kinetic model of Nav1.8, we showed that a reduction of Nav1.8 current by even 25\u201350% increases rheobase and reduces firing probability in small DRG neurons expressing Nav1.7L848H. Nav1.8 subtraction also reduces the amplitudes of subthreshold membrane potential oscillations in these cells. Our results show that within DRG neurons that express peripheral sodium channel Nav1.7, the Nav1.8 channel amplifies excitability at a broad range of membrane voltages with a predominant effect close to the AP voltage threshold, while Nav1.7 plays a major role at voltages closer to resting membrane potential. Our data show that dynamic-clamp reduction of Nav1.8 conductance by 25\u201350% can reverse hyperexcitability of DRG neurons expressing a gain-of-function Nav1.7 mutation that causes pain in humans and suggests, more generally, that full inhibition of Nav1.8 may not be required for relief of pain due to DRG neuron hyperexcitability.<\/jats:p>","DOI":"10.1085\/jgp.202413596","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:32:27Z","timestamp":1728390747000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain"],"prefix":"10.1085","volume":"156","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3523-2249","authenticated-orcid":true,"given":"Dmytro V.","family":"Vasylyev","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pnmqc26","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University School of Medicine 1 Department of Neurology and Center for Neuroscience and Regeneration Research, , New Haven, CT,","place":["USA"]},{"name":"Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System 2 , West Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-3044","authenticated-orcid":true,"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pnmqc26","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University School of Medicine 1 Department of Neurology and Center for Neuroscience and Regeneration Research, , New Haven, CT,","place":["USA"]},{"name":"Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System 2 , West Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-9091","authenticated-orcid":true,"given":"Betsy R.","family":"Schulman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pnmqc26","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University School of Medicine 1 Department of Neurology and Center for Neuroscience and Regeneration Research, , New Haven, CT,","place":["USA"]},{"name":"Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System 2 , West Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5718-7177","authenticated-orcid":true,"given":"Stephen G.","family":"Waxman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03pnmqc26","id-type":"ROR","asserted-by":"publisher"}],"name":"Yale University School of Medicine 1 Department of Neurology and Center for Neuroscience and Regeneration Research, , New Haven, CT,","place":["USA"]},{"name":"Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System 2 , West Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"2025100720023279600_bib1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/379257a0","article-title":"A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons","volume":"379","author":"Akopian","year":"1996","journal-title":"Nature"},{"key":"2025100720023279600_bib2","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/9195","article-title":"The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways","volume":"2","author":"Akopian","year":"1999","journal-title":"Nat. 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