{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:10:13Z","timestamp":1779333013703,"version":"3.51.4"},"reference-count":52,"publisher":"Rockefeller University Press","issue":"6","license":[{"start":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T00:00:00Z","timestamp":1759795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/rupress.org\/pages\/terms102024"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 HL171542"],"award-info":[{"award-number":["R35 HL171542"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AHA 25POST1366289"],"award-info":[{"award-number":["AHA 25POST1366289"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK056341"],"award-info":[{"award-number":["P30 DK056341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:p>Cantu syndrome (CS) is a rare disease caused by gain-of-function (GOF) mutations of Kir6.1 or SUR2 subunits of ATP-sensitive potassium (KATP) channels. CS patients with SUR2 and Kir6.1 variants display a similar constellation of symptoms, including muscle weakness and fatigue. The effects of CS mutations on skeletal muscle KATP channels, and any consequent direct effects on contractility, are currently unclear. Here, we used two knock-in mouse models of CS, respectively, carrying GOF mutations Kir6.1[V65M] or SUR2[A478V], to assess KATP channel properties and contractility in isolated fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus (SOL) muscles. Electrophysiological recordings in isolated myofibers showed normal resting potentials, and excised patch-clamp recordings showed normal KATP channel density in both genotypes, but enhanced Mg-nucleotide activation only in SUR2[A478V] fibers, consistent with muscle KATP channels being formed predominantly as complexes of SUR2A and Kir6.2 subunits. Ex vivo testing of isolated SUR2[A478V], but not Kir6.1[V65M], muscles showed an earlier onset of fatigue and a marked intra-tetanic decline of force compared with littermate controls. Importantly, normal contractile behavior was restored ex vivo and in vivo in SUR2[A478V] muscles in the presence of the FDA-approved KATP channel inhibitor glibenclamide, indicating that the increased fatigue of isolated muscles is a direct consequence of overactive sarcolemmal KATP channels. These results shed light on the pathophysiologic relevance of SUR2-dependent KATP channel subunits in skeletal muscle and highlight their role in fatiguing conditions, as well as identifying potential therapeutic benefit of skeletal muscle KATP inhibition in CS.<\/jats:p>","DOI":"10.1085\/jgp.202513781","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:49:38Z","timestamp":1759844978000},"update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Muscle fatigue arising intrinsically from SUR2- but not Kir6.1-dependent gain-of-function in Cantu syndrome mice"],"prefix":"10.1085","volume":"157","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1370-2012","authenticated-orcid":true,"given":"Rosa","family":"Scala","sequence":"first","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7417-8871","authenticated-orcid":true,"given":"Maya","family":"Mukadam","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0265-5067","authenticated-orcid":true,"given":"Yuezhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1519-1503","authenticated-orcid":true,"given":"Courtney","family":"Frazier","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-0900","authenticated-orcid":true,"given":"Nathaniel W.","family":"York","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9486-884X","authenticated-orcid":true,"given":"Robert C.","family":"Tryon","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-3993","authenticated-orcid":true,"given":"Gretchen A.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Program in Physical Therapy, Neurology and Biomedical Engineering, Washington University School of Medicine 2 Departments of Orthopedic Surgery, , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-2134","authenticated-orcid":true,"given":"Colin G.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine 1 , St. Louis, MO,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"2025100709491585900_bib1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cmet.2009.11.009","article-title":"Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight","volume":"11","author":"Alekseev","year":"2010","journal-title":"Cell Metab."},{"key":"2025100709491585900_bib2","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1111\/j.1440-1681.2004.04032.x","article-title":"Skeletal muscle function: Role of ionic changes in fatigue, damage and disease","volume":"31","author":"Allen","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2025100709491585900_bib3","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1002\/ajmg.a.62710","article-title":"Cant\u00f9 syndrome: Report of a patient with a novel variant in KCNJ8 and revision of literature","volume":"188","author":"Apuril Velgara","year":"2022","journal-title":"Am. J. Med. Genet. A"},{"key":"2025100709491585900_bib4","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1242\/jcs.141440","article-title":"Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes","volume":"127","author":"Arakel","year":"2014","journal-title":"J. Cell Sci."},{"key":"2025100709491585900_bib5","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.1111\/bph.16390","article-title":"Identification and characterisation of functional K(ir)6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane","volume":"181","author":"Brennan","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"2025100709491585900_bib6","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1016\/j.ejmg.2013.09.009","article-title":"Mutation of KCNJ8 in a patient with Cant\u00fa syndrome with unique vascular abnormalities - support for the role of K(ATP) channels in this condition","volume":"56","author":"Brownstein","year":"2013","journal-title":"Eur. J. Med. Genet."},{"key":"2025100709491585900_bib7","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/mus.880180814","article-title":"High-frequency fatigue in rat skeletal muscle: Role of extracellular ion concentrations","volume":"18","author":"Cairns","year":"1995","journal-title":"Muscle Nerve"},{"key":"2025100709491585900_bib8","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/BF00281261","article-title":"A distinct osteochondrodysplasia with hypertrichosis- Individualization of a probable autosomal recessive entity","volume":"60","author":"Cant\u00fa","year":"1982","journal-title":"Hum. Genet."},{"key":"2025100709491585900_bib9","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.exger.2010.04.001","article-title":"Slow twitch soleus muscle is not protected from sarcopenia in senescent rats","volume":"45","author":"Carter","year":"2010","journal-title":"Exp. Gerontol."},{"key":"2025100709491585900_bib10","doi-asserted-by":"publisher","first-page":"e476","DOI":"10.1111\/jdv.16384","article-title":"A novel mutation in the KCNJ8 gene encoding the Kir6.1 subunit of an ATP-sensitive potassium channel in a Japanese patient with Cant\u00fa syndrome","volume":"34","author":"Chihara","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2025100709491585900_bib11","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1111\/j.1469-7793.1998.831bd.x","article-title":"The contribution of pH-dependent mechanisms to fatigue at different intensities in mammalian single muscle fibres","volume":"512","author":"Chin","year":"1998","journal-title":"J. Physiol."},{"key":"2025100709491585900_bib12","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.2337\/diab.45.10.1439","article-title":"Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels","volume":"45","author":"Chutkow","year":"1996","journal-title":"Diabetes"},{"key":"2025100709491585900_bib13","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1113\/expphysiol.2008.042572","article-title":"Contractile dysfunctions in ATP-dependent K+ channel-deficient mouse muscle during fatigue involve excessive depolarization and Ca2+ influx through L-type Ca2+ channels","volume":"93","author":"Cifelli","year":"2008","journal-title":"Exp. Physiol."},{"key":"2025100709491585900_bib14","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/humu.22555","article-title":"Cant\u00fa syndrome resulting from activating mutation in the KCNJ8 gene","volume":"35","author":"Cooper","year":"2014","journal-title":"Hum. Mutat."},{"key":"2025100709491585900_bib15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1085\/jgp.201511495","article-title":"Differential mechanisms of Cant\u00fa syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel","volume":"146","author":"Cooper","year":"2015","journal-title":"J. Gen. Physiol."},{"key":"2025100709491585900_bib16","doi-asserted-by":"publisher","first-page":"zqad017","DOI":"10.1093\/function\/zqad017","article-title":"Lymphatic contractile dysfunction in mouse models of Cant\u00fa Syndrome with KATP channel gain-of-function","volume":"4","author":"Davis","year":"2023","journal-title":"Function"},{"key":"2025100709491585900_bib17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2418021122","article-title":"Potassium-sensitive loss of muscle force in the setting of reduced inward rectifier K(+) current: Implications for Andersen-Tawil syndrome","volume":"122","author":"Elia","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025100709491585900_bib18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.yjmcc.2011.04.016","article-title":"Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts","volume":"51","author":"Fedorov","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2025100709491585900_bib19","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1161\/CIRCRESAHA.108.178186","article-title":"Differential structure of atrial and ventricular KATP: Atrial KATP channels require SUR1","volume":"103","author":"Flagg","year":"2008","journal-title":"Circ. Res."},{"key":"2025100709491585900_bib20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.yjmcc.2005.01.005","article-title":"Sarcolemmal K(ATP) channels: What do we really know?","volume":"39","author":"Flagg","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"2025100709491585900_bib21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1007\/s00421-008-0796-5","article-title":"High-frequency fatigue of skeletal muscle: Role of extracellular Ca(2+)","volume":"104","author":"Germinario","year":"2008","journal-title":"Eur. J. Appl. Physiol."},{"key":"2025100709491585900_bib22","doi-asserted-by":"publisher","first-page":"C1464","DOI":"10.1152\/ajpcell.00278.2003","article-title":"KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle","volume":"285","author":"Gong","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025100709491585900_bib23","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/ajmg.c.31753","article-title":"Cant\u00fa syndrome: Findings from 74 patients in the international Cant\u00fa syndrome registry","volume":"181","author":"Grange","year":"2019","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"2025100709491585900_bib24","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/ng.2324","article-title":"Dominant missense mutations in ABCC9 cause Cant\u00fa syndrome","volume":"44","author":"Harakalova","year":"2012","journal-title":"Nat. Genet."},{"key":"2025100709491585900_bib25","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.121153","article-title":"Cardiovascular consequences of KATP overactivity in Cantu syndrome","volume":"3","author":"Huang","year":"2018","journal-title":"JCI Insight"},{"key":"2025100709491585900_bib26","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/s0896-6273(00)80124-5","article-title":"A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels","volume":"16","author":"Inagaki","year":"1996","journal-title":"Neuron"},{"key":"2025100709491585900_bib27","doi-asserted-by":"publisher","first-page":"17704","DOI":"10.1038\/s41598-025-00547-9","article-title":"Treatment of overactive KATP channels with glibenclamide in a zebrafish model and a clinical trial in humans with Cant\u00fa syndrome","volume":"15","author":"Kleinendorst","year":"2025","journal-title":"Sci. Rep."},{"key":"2025100709491585900_bib28","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1212\/WNL.0000000000000239","article-title":"A Kir3.4 mutation causes Andersen-Tawil syndrome by an inhibitory effect on Kir2.1","volume":"82","author":"Kokunai","year":"2014","journal-title":"Neurology"},{"key":"2025100709491585900_bib29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1113\/jphysiol.1994.sp020088","article-title":"The effect of glibenclamide on frog skeletal muscle: Evidence for K+ATP channel activation during fatigue","volume":"475","author":"Light","year":"1994","journal-title":"J. Physiol."},{"key":"2025100709491585900_bib30","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1469-7793.2001.00591.x","article-title":"Force and power output of fast and slow skeletal muscles from mdx mice 6-28 months old","volume":"535","author":"Lynch","year":"2001","journal-title":"J. Physiol."},{"key":"2025100709491585900_bib31","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1002\/ajmg.a.61200","article-title":"Glibenclamide treatment in a Cant\u00fa syndrome patient with a pathogenic ABCC9 gain-of-function variant: Initial experience","volume":"179","author":"Ma","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"2025100709491585900_bib32","doi-asserted-by":"publisher","first-page":"C404","DOI":"10.1152\/ajpcell.2000.278.2.C404","article-title":"Pinacidil suppresses contractility and preserves energy but glibenclamide has no effect during muscle fatigue","volume":"278","author":"Matar","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2025100709491585900_bib33","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.6928","article-title":"Cant\u00fa syndrome: A new case and evolution of clinical conditions during first 2-year follow-up","volume":"11","author":"Mattiucci","year":"2023","journal-title":"Clin. Case Rep."},{"key":"2025100709491585900_bib34","doi-asserted-by":"publisher","first-page":"zqaa004","DOI":"10.1093\/function\/zqaa004","article-title":"The mechanism of high-output cardiac hypertrophy arising from potassium channel gain-of-function in Cant\u00fa syndrome","volume":"1","author":"McClenaghan","year":"2020","journal-title":"Function"},{"key":"2025100709491585900_bib35","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1172\/JCI130571","article-title":"Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity","volume":"130","author":"McClenaghan","year":"2020","journal-title":"J. Clin. Invest."},{"key":"2025100709491585900_bib36","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202216883","article-title":"Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS","volume":"15","author":"McClenaghan","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"2025100709491585900_bib37","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/BF00121294","article-title":"Time course study of the isometric contractile properties of mdx mouse striated muscles","volume":"14","author":"Pastoret","year":"1993","journal-title":"J. Muscle Res. Cell Motil."},{"key":"2025100709491585900_bib38","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1085\/jgp.200910290","article-title":"Regulation of ClC-1 and KATP channels in action potential-firing fast-twitch muscle fibers","volume":"134","author":"Pedersen","year":"2009","journal-title":"J. Gen. Physiol."},{"key":"2025100709491585900_bib39","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00421-023-05270-9","article-title":"Exercise and fatigue: Integrating the role of K(+), Na(+) and Cl(\u2212) in the regulation of sarcolemmal excitability of skeletal muscle","volume":"123","author":"Renaud","year":"2023","journal-title":"Eur. J. Appl. Physiol."},{"key":"2025100709491585900_bib40","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cell.2009.12.024","article-title":"Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis","volume":"140","author":"Ryan","year":"2010","journal-title":"Cell"},{"key":"2025100709491585900_bib41","doi-asserted-by":"publisher","first-page":"604885","DOI":"10.3389\/fphar.2020.604885","article-title":"Pathophysiological consequences of KATP channel overactivity and pharmacological response to glibenclamide in skeletal muscle of a murine model of Cant\u00f9 syndrome","volume":"11","author":"Scala","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2025100709491585900_bib42","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.3390\/cells10071791","article-title":"Consequences of SUR2[A478V] mutation in skeletal muscle of murine model of Cantu syndrome","volume":"10","author":"Scala","year":"2021","journal-title":"Cells"},{"key":"2025100709491585900_bib43","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/ajmg.a.33885","article-title":"Cant\u00fa syndrome: Report of nine new cases and expansion of the clinical phenotype","volume":"155A","author":"Scurr","year":"2011","journal-title":"Am. J. Med. Genet. A"},{"key":"2025100709491585900_bib44","doi-asserted-by":"publisher","first-page":"37176","DOI":"10.1074\/jbc.M206757200","article-title":"Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose","volume":"277","author":"Shiota","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2025100709491585900_bib45","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s00441-017-2696-7","article-title":"Andersen\u2019s syndrome mutants produce a knockdown of inwardly rectifying K(+) channel in mouse skeletal muscle in vivo","volume":"371","author":"Simkin","year":"2018","journal-title":"Cell Tissue Res."},{"key":"2025100709491585900_bib46","doi-asserted-by":"publisher","first-page":"4457","DOI":"10.1038\/s41467-019-12428-7","article-title":"ABCC9-related Intellectual disability Myopathy Syndrome is a K(ATP) channelopathy with loss-of-function mutations in ABCC9","volume":"10","author":"Smeland","year":"2019","journal-title":"Nat. Commun."},{"key":"2025100709491585900_bib47","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1073\/pnas.0505974103","article-title":"Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties","volume":"103","author":"Tricarico","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025100709491585900_bib48","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.ajhg.2012.04.014","article-title":"Cant\u00fa syndrome is caused by mutations in ABCC9","volume":"90","author":"van Bon","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"2025100709491585900_bib50","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1152\/physiologyonline.2002.17.1.17","article-title":"Muscle fatigue: Lactic acid or inorganic phosphate the major cause?","volume":"17","author":"Westerblad","year":"2002","journal-title":"News Physiol. Sci."},{"key":"2025100709491585900_bib51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.141443","article-title":"Kir6.1- and SUR2-dependent KATP overactivity disrupts intestinal motility in murine models of Cantu syndrome","volume":"5","author":"York","year":"2020","journal-title":"JCI Insight"},{"key":"2025100709491585900_bib52","doi-asserted-by":"publisher","first-page":"376","DOI":"10.2337\/db24-0650","article-title":"Loss of beta-cell KATP reduces Ca2+ sensitivity of insulin secretion and Trpm5 expression","volume":"74","author":"York","year":"2025","journal-title":"Diabetes"},{"key":"2025100709491585900_bib53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1085\/jgp.201311063","article-title":"Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads","volume":"143","author":"Zhu","year":"2014","journal-title":"J. Gen. Physiol."}],"container-title":["Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/doi\/10.1085\/jgp.202513781\/1950957\/jgp_202513781.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/doi\/10.1085\/jgp.202513781\/1950957\/jgp_202513781.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:49:39Z","timestamp":1759844979000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/157\/6\/e202513781\/278353\/Muscle-fatigue-arising-intrinsically-from-SUR2-but"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,7]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11,3]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.202513781","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,7]]},"article-number":"e202513781"}}