{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:44:56Z","timestamp":1758278696148},"reference-count":0,"publisher":"Rockefeller University Press","issue":"2","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1952,11,20]]},"abstract":"<jats:p>Albino rats weighing 160 to 175 gm. were fed a complete synthetic diet containing 0.003 per cent potassium and 0.7 per cent sodium for 40 days. Controls were given the same diet plus adequate added potassium.<\/jats:p>\n               <jats:p>1. Data from analyses of serum and skeletal muscle showed (a) a fall in serum chloride concentration and an increase in serum carbon dioxide concentration and pH in the potassium-deficient rats; (b) increases of sodium, magnesium, and calcium and a decrease of potassium in the muscle of the potassium-deficient rats; (c) no change of muscle chloride or carbon dioxide concentrations in the potassium-deficient rats.<\/jats:p>\n               <jats:p>(2) Application of the Wallace-Hastings calculations to these data revealed (a) intracellular pH of the skeletal muscle of the normal rat to be 6.98 \u00b1 0.08; (b) an increase in serum partial pressure of carbon dioxide (pCO2) in potassium deficiency, together with increases in concentrations of [H2CO2] and [HCO3-] per kg. extracellular water and [H2CO3] per kg. cell water; (c) a decrease in values for [CO2] and [HCO3-] per kg. intracellular water; (d) a fall of intracellular pH in potassium deficiency to 6.42 \u00b1 0.05.<\/jats:p>\n               <jats:p>(3) Analyses of sacrospinalis muscle from five men undergoing operation for ruptured intervertebral disc showed a mean value of 9.46 \u00b1 1.31 mM carbon dioxide per kg. blood-free tissue.<\/jats:p>\n               <jats:p>Some problems of interpretation of data are briefly discussed.<\/jats:p>","DOI":"10.1085\/jgp.36.2.153","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T21:41:10Z","timestamp":1084484470000},"page":"153-159","update-policy":"http:\/\/dx.doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["EFFECT OF POTASSIUM DEFICIENCY ON CARBON DIOXIDE, CATION, AND PHOSPHATE CONTENT OF MUSCLE"],"prefix":"10.1085","volume":"36","author":[{"given":"Lytt I.","family":"Gardner","sequence":"first","affiliation":[{"name":"From the Burnham Memorial Hospital for Children, Massachusetts General Hospital, and the Department of Pediatrics, Harvard Medical School, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsie A.","family":"MacLachlan","sequence":"additional","affiliation":[{"name":"From the Burnham Memorial Hospital for Children, Massachusetts General Hospital, and the Department of Pediatrics, Harvard Medical School, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Berman","sequence":"additional","affiliation":[{"name":"From the Burnham Memorial Hospital for Children, Massachusetts General Hospital, and the Department of Pediatrics, Harvard Medical School, Boston"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1952,11,20]]},"container-title":["Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/rupress.org\/jgp\/article-pdf\/36\/2\/153\/1240724\/153.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/rupress.org\/jgp\/article-pdf\/36\/2\/153\/1240724\/153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T19:29:30Z","timestamp":1601753370000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/36\/2\/153\/47434\/EFFECT-OF-POTASSIUM-DEFICIENCY-ON-CARBON-DIOXIDE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1952,11,20]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1952,11,20]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.36.2.153","relation":{},"ISSN":["1540-7748","0022-1295"],"issn-type":[{"value":"1540-7748","type":"electronic"},{"value":"0022-1295","type":"print"}],"subject":[],"published":{"date-parts":[[1952,11,20]]}}}