{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:36:27Z","timestamp":1792150587324,"version":"4.4.0"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"1","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1961,9,1]]},"abstract":"<jats:p>A \"translation\" of the phenomenological permeability coefficients into friction and distribution coefficients amenable to physical interpretation is presented. Expressions are obtained for the solute permeability coefficient \u03c9 and the reflection coefficient \u03c3 for both non-electrolytic and electrolytic permeants. An analysis of the coefficients is given for loose membranes as well as for dense natural membranes where transport may go through capillaries or by solution in the lipoid parts of the membrane. Water diffusion and filtration and the relation between these and capillary pore radius of the membrane are discussed. For the permeation of ions through the charged membranes equations are developed for the case of zero electrical current in the membrane. The correlation of \u03c3 with \u03c9 and Lp for electrolytes resembles that for non-electrolytes. In this case \u03c9 and \u03c3 depend markedly on ion concentration and on the charge density of the membrane. The reflection coefficient may assume negative values indicating anomalous osmosis. An analysis of the phenomena of anomalous osmosis was carried out for the model of Teorell and Meyer and Sievers and the results agree with the experimental data of Loeb and of Grim and Sollner. A set of equations and reference curves are presented for the evaluation of \u03c9 and \u03c3 in the transport of polyvalent ions through charged membranes.<\/jats:p>","DOI":"10.1085\/jgp.45.1.143","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T22:11:52Z","timestamp":1084486312000},"page":"143-179","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":582,"title":["A Physical Interpretation of the Phenomenological Coefficients of Membrane Permeability"],"prefix":"10.1085","volume":"45","author":[{"given":"O.","family":"Kedem","sequence":"first","affiliation":[{"name":"From the Weizmann Institute of Science, Rehovoth, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katchalsky","sequence":"additional","affiliation":[{"name":"From the Weizmann Institute of Science, Rehovoth, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[1961,9,1]]},"container-title":["The Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/45\/1\/143\/1806159\/143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/45\/1\/143\/1806159\/143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T07:49:19Z","timestamp":1690444159000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/45\/1\/143\/30570\/A-Physical-Interpretation-of-the-Phenomenological"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1961,9,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1961,9,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.45.1.143","relation":{},"ISSN":["1540-7748","0022-1295"],"issn-type":[{"value":"1540-7748","type":"electronic"},{"value":"0022-1295","type":"print"}],"subject":[],"published":{"date-parts":[[1961,9,1]]}}}