{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:20:50Z","timestamp":1778962850058,"version":"3.51.4"},"reference-count":0,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,6,1]]},"abstract":"<jats:p>Electroretinogram (ERG) and extracellular potassium activity (K+o) measurements were carried out in isolated superfused rabbit eyecup preparations under control conditions and during the application of pharmacological agents that selectively modify the light-responsive retinal network. Light-evoked K+o changes in the rabbit (E-type) retina resemble those previously described in amphibian (I-type) retinas. Different components of the light-evoked K+o changes can be distinguished on the bases of retinal depth, V vs. log I properties, and their responses to pharmacological agents. We find two separable sources of light-evoked increases in extracellular K+: a proximal source and a distal source. The properties of the distal light-evoked K+o increase are consistent with the hypothesis that it initiates a K+-mediated current through M\u00fcller cells that is detected as the primary voltage of the electroretinographic b-wave. These experiments also support previous studies indicating that both the corneal-positive component of c-wave and the corneal-negative slow PIII potential result from K+-mediated influences on, respectively, the retinal pigment epithelium and M\u00fcller cells.<\/jats:p>","DOI":"10.1085\/jgp.85.6.911","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T23:16:46Z","timestamp":1084490206000},"page":"911-931","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Extracellular K+ activity changes related to electroretinogram components. II. Rabbit (E-type) retinas."],"prefix":"10.1085","volume":"85","author":[{"given":"E","family":"Dick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bloomfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"291","published-online":{"date-parts":[[1985,6,1]]},"container-title":["The Journal of general physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/85\/6\/911\/1812991\/911.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/85\/6\/911\/1812991\/911.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T12:17:53Z","timestamp":1690460273000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/85\/6\/911\/27383\/Extracellular-K-activity-changes-related-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,6,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.85.6.911","relation":{},"ISSN":["0022-1295","1540-7748"],"issn-type":[{"value":"0022-1295","type":"print"},{"value":"1540-7748","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,6,1]]}}}