{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:03:23Z","timestamp":1778634203991,"version":"3.51.4"},"reference-count":36,"publisher":"Rockefeller University Press","issue":"6","content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"DOI":"10.1085\/jgp.201010508","type":"journal-article","created":{"date-parts":[[2010,11,29]],"date-time":"2010-11-29T16:58:49Z","timestamp":1291049929000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1085\/jgp.crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["310 helices in channels and other membrane proteins"],"prefix":"10.1085","volume":"136","author":[{"given":"Ricardo Sim\u00e3o","family":"Vieira-Pires","sequence":"first","affiliation":[{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal"}]},{"given":"Jo\u00e3o Henrique","family":"Morais-Cabral","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150-180 Porto, Portugal"}]}],"member":"291","published-online":{"date-parts":[[2010,11,29]]},"reference":[{"key":"2023072622053814800_bib1","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/S0896-6273(00)80143-9","article-title":"Contribution of the S4 segment to gating charge in the Shaker K+ channel","volume":"16","author":"Aggarwal","year":"1996","journal-title":"Neuron."},{"key":"2023072622053814800_bib2","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1110\/ps.0240103","article-title":"The role of alpha-, 3(10)-, and pi-helix in helix\u2014>coil transitions","volume":"12","author":"Armen","year":"2003","journal-title":"Protein Sci."},{"key":"2023072622053814800_bib3","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/0022-2836(88)90641-9","article-title":"Helix geometry in proteins","volume":"201","author":"Barlow","year":"1988","journal-title":"J. Mol. Biol."},{"key":"2023072622053814800_bib4","first-page":"407","article-title":"Solvent polarity controls the helical conformation of short peptides rich in Calpha-tetrasubstituted amino acids","volume":"13","author":"Bellanda","year":"2007","journal-title":"Chemistry (Easton)."},{"key":"2023072622053814800_bib5","doi-asserted-by":"publisher","first-page":"e1000289","DOI":"10.1371\/journal.pcbi.1000289","article-title":"Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel","volume":"5","author":"Bjelkmar","year":"2009","journal-title":"PLOS Comput. Biol."},{"key":"2023072622053814800_bib6","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/nsb1197-915","article-title":"Helix packing angle preferences","volume":"4","author":"Bowie","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"2023072622053814800_bib7","doi-asserted-by":"publisher","first-page":"11352","DOI":"10.1073\/pnas.1000142107","article-title":"Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072622053814800_bib8","doi-asserted-by":"publisher","first-page":"11912","DOI":"10.1021\/ja980010o","article-title":"Folding and translocation of the undecamer of poly-L-leucine across the water-hexane interface. A molecular dynamics study","volume":"120","author":"Chipot","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"2023072622053814800_bib9","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.cell.2004.10.030","article-title":"Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel","volume":"119","author":"Clayton","year":"2004","journal-title":"Cell."},{"key":"2023072622053814800_bib10","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1073\/pnas.0711533105","article-title":"Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel","volume":"105","author":"Clayton","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072622053814800_bib11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/bip.20357","article-title":"Peptide helices based on alpha-amino acids","volume":"84","author":"Crisma","year":"2006","journal-title":"Biopolymers."},{"key":"2023072622053814800_bib12","doi-asserted-by":"publisher","first-page":"22498","DOI":"10.1073\/pnas.0912307106","article-title":"Sequential formation of ion pairs during activation of a sodium channel voltage sensor","volume":"106","author":"DeCaen","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072622053814800_bib13","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jsb.2006.07.006","article-title":"Solution structure of amphibian tachykinin Uperolein bound to DPC micelles","volume":"156","author":"Dike","year":"2006","journal-title":"J. Struct. Biol."},{"key":"2023072622053814800_bib14","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1002\/prot.21026","article-title":"3(10)-helices in proteins are parahelices","volume":"64","author":"Enkhbayar","year":"2006","journal-title":"Proteins."},{"key":"2023072622053814800_bib15","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/nsb0694-374","article-title":"A single carboxy-terminal arginine determines the amino-terminal helix conformation of an alanine-based peptide","volume":"1","author":"Fiori","year":"1994","journal-title":"Nat. Struct. Biol."},{"key":"2023072622053814800_bib16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nature01580","article-title":"X-ray structure of a voltage-dependent K+ channel","volume":"423","author":"Jiang","year":"2003","journal-title":"Nature."},{"key":"2023072622053814800_bib17","doi-asserted-by":"publisher","first-page":"6747","DOI":"10.1021\/bi00481a001","article-title":"Structural characteristics of alpha-helical peptide molecules containing Aib residues","volume":"29","author":"Karle","year":"1990","journal-title":"Biochemistry."},{"key":"2023072622053814800_bib18","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1002\/pro.5560030920","article-title":"Facile transition between 3(10)- and alpha-helix: structures of 8-, 9-, and 10-residue peptides containing the -(Leu-Aib-Ala)2-Phe-Aib- fragment","volume":"3","author":"Karle","year":"1994","journal-title":"Protein Sci."},{"key":"2023072622053814800_bib19","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1016\/j.bpj.2010.02.056","article-title":"Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel","volume":"98","author":"Khalili-Araghi","year":"2010","journal-title":"Biophys. J."},{"key":"2023072622053814800_bib20","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1126\/science.1116269","article-title":"Crystal structure of a mammalian voltage-dependent Shaker family K+ channel","volume":"309","author":"Long","year":"2005","journal-title":"Science."},{"key":"2023072622053814800_bib21","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1126\/science.1116270","article-title":"Voltage sensor of Kv1.2: structural basis of electromechanical coupling","volume":"309","author":"Long","year":"2005","journal-title":"Science."},{"key":"2023072622053814800_bib22","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature06265","article-title":"Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment","volume":"450","author":"Long","year":"2007","journal-title":"Nature."},{"key":"2023072622053814800_bib23","doi-asserted-by":"publisher","first-page":"13789","DOI":"10.1021\/ja062269+","article-title":"Direct UV Raman monitoring of 3(10)-helix and pi-bulge premelting during alpha-helix unfolding","volume":"128","author":"Mikhonin","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"2023072622053814800_bib24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1085\/jgp.200409133","article-title":"A cyclic nucleotide modulated prokaryotic K+ channel","volume":"124","author":"Nimigean","year":"2004","journal-title":"J. Gen. Physiol."},{"key":"2023072622053814800_bib25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/312121a0","article-title":"Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence","volume":"312","author":"Noda","year":"1984","journal-title":"Nature."},{"key":"2023072622053814800_bib26","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1093\/protein\/12.10.811","article-title":"Novel protein structural motifs containing two-turn and longer 3(10)-helices","volume":"12","author":"Pal","year":"1999","journal-title":"Protein Eng."},{"key":"2023072622053814800_bib27","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1073\/pnas.37.4.205","article-title":"The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain","volume":"37","author":"Pauling","year":"1951","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072622053814800_bib28","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nsb1296-991","article-title":"A leucine-rich repeat variant with a novel repetitive protein structural motif","volume":"3","author":"Peters","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"2023072622053814800_bib29","doi-asserted-by":"publisher","first-page":"9100","DOI":"10.1021\/jp7119813","article-title":"Helix forming tendency of valine substituted poly-alanine: a molecular dynamics investigation","volume":"112","author":"Raman","year":"2008","journal-title":"J. Phys. Chem. B."},{"key":"2023072622053814800_bib30","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/S0896-6273(00)80142-7","article-title":"Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel","volume":"16","author":"Seoh","year":"1996","journal-title":"Neuron."},{"key":"2023072622053814800_bib31","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nature07620","article-title":"Sensing voltage across lipid membranes","volume":"456","author":"Swartz","year":"2008","journal-title":"Nature."},{"key":"2023072622053814800_bib32","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1021\/bi00230a009","article-title":"Molecular dynamics simulations of the unfolding of an alpha-helical analogue of ribonuclease A S-peptide in water","volume":"30","author":"Tirado-Rives","year":"1991","journal-title":"Biochemistry."},{"key":"2023072622053814800_bib33","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev.cellbio.21.020404.145837","article-title":"How does voltage open an ion channel?","volume":"22","author":"Tombola","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2023072622053814800_bib34","doi-asserted-by":"publisher","first-page":"17600","DOI":"10.1073\/pnas.0807387105","article-title":"S4-based voltage sensors have three major conformations","volume":"105","author":"Villalba-Galea","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023072622053814800_bib35","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1110\/ps.04712004","article-title":"The progress of membrane protein structure determination","volume":"13","author":"White","year":"2004","journal-title":"Protein Sci."},{"key":"2023072622053814800_bib36","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cell.2010.07.013","article-title":"A shaker K+ channel with a miniature engineered voltage sensor","volume":"142","author":"Xu","year":"2010","journal-title":"Cell."}],"container-title":["Journal of General Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/136\/6\/585\/1788520\/jgp_201010508.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jgp\/article-pdf\/136\/6\/585\/1788520\/jgp_201010508.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T22:06:06Z","timestamp":1690409166000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jgp\/article\/136\/6\/585\/42884\/310-helices-in-channels-and-other-membrane"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,29]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12,1]]}},"URL":"https:\/\/doi.org\/10.1085\/jgp.201010508","relation":{},"ISSN":["1540-7748","0022-1295"],"issn-type":[{"value":"1540-7748","type":"electronic"},{"value":"0022-1295","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11,29]]}}}