{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:51:55Z","timestamp":1776977515080,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":5344,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[1998,12]]},"DOI":"10.1086\/302172","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:47:41Z","timestamp":1027694861000},"page":"1578-1587","source":"Crossref","is-referenced-by-count":148,"title":["Molecular Genetics of the Caveolin Gene Family: Implications for Human Cancers, Diabetes, Alzheimer Disease, and Muscular Dystrophy"],"prefix":"10.1016","volume":"63","author":[{"given":"Jeffrey A.","family":"Engelman","sequence":"first","affiliation":[]},{"given":"XiaoLan","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Ferruccio","family":"Galbiati","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Volont\u00e9","sequence":"additional","affiliation":[]},{"given":"Federica","family":"Sotgia","sequence":"additional","affiliation":[]},{"given":"Richard G.","family":"Pestell","sequence":"additional","affiliation":[]},{"given":"Carlo","family":"Minetti","sequence":"additional","affiliation":[]},{"given":"Philipp E.","family":"Scherer","sequence":"additional","affiliation":[]},{"given":"Takashi","family":"Okamoto","sequence":"additional","affiliation":[]},{"given":"Michael P.","family":"Lisanti","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1086\/302172_bib2","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1074\/jbc.272.10.6525","article-title":"Identification of peptide and protein ligands for the caveolin-scaffolding domain: implications for the interaction of caveolin with caveolae-associated proteins","volume":"272","author":"Couet","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1050-1738(97)00001-7","article-title":"Molecular and cellular biology of caveolae: paradoxes and plasticities","volume":"7","author":"Couet","year":"1997","journal-title":"Trends Cardiovasc Med"},{"key":"10.1086\/302172_bib3","doi-asserted-by":"crossref","first-page":"30429","DOI":"10.1074\/jbc.272.48.30429","article-title":"Interaction of a receptor tyrosine kinase, EGF-R, with caveolins: caveolin binding negatively regulates tyrosine and serine\/threonine kinase activities","volume":"272","author":"Couet","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-5793(98)00470-0","article-title":"Caveolin-mediated regulation of signaling along the p42\/44 MAP kinase cascade in vivo: a role for the caveolin-scaffolding domain","volume":"428","author":"Engelman","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib5","doi-asserted-by":"crossref","first-page":"20448","DOI":"10.1074\/jbc.273.32.20448","article-title":"Reciprocal regulation of Neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo: implications for human breast cancer","volume":"273","author":"Engelman","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib6","doi-asserted-by":"crossref","first-page":"16374","DOI":"10.1074\/jbc.272.26.16374","article-title":"Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth","volume":"272","author":"Engelman","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib7","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0014-5793(98)00619-X","article-title":"Chromosomal localization, genomic organization, and developmental expression of the murine caveolin gene family (Cav-1, -2, and -3): Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2\/7q31)","volume":"429","author":"Engelman","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0014-5793(98)01134-X","article-title":"Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers","volume":"436","author":"Engelman","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0092-8674(00)81075-2","article-title":"Molecular glue: kinase anchoring and scaffold proteins","volume":"85","author":"Faux","year":"1996","journal-title":"Cell"},{"key":"10.1086\/302172_bib10","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1093\/emboj\/17.22.6633","article-title":"Targeted down-regulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42\/44 MAP kinase cascade","volume":"17","author":"Galbiati","year":"1998","journal-title":"EMBO J"},{"key":"10.1086\/302172_bib11","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1073\/pnas.95.17.10257","article-title":"Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: caveolin-2 is upregulated in response to cell injury","volume":"95","author":"Galbiati","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib12","doi-asserted-by":"crossref","first-page":"25437","DOI":"10.1074\/jbc.272.41.25437","article-title":"Dissecting the interaction between nitric oxide synthase (NOS) and caveolin: functional significance of the NOS caveolin binding domain in vivo","volume":"272","author":"Garcia-Cardena","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/339155a0","article-title":"Tyrosine kinase receptor indistinguishable from the c-met protein","volume":"339","author":"Giordano","year":"1989","journal-title":"Nature"},{"key":"10.1086\/302172_bib14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-5793(92)81458-X","article-title":"The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles","volume":"314","author":"Glenney","year":"1992","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib15","doi-asserted-by":"crossref","first-page":"10485","DOI":"10.1074\/jbc.273.17.10485","article-title":"Caveolae, plasma membrane micro-domains for \u03b1-secretase-mediated processing of the amyloid precursor protein (APP)","volume":"273","author":"Ikezu","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0006-8993(98)00498-3","article-title":"Affinity-purification and characterization of caveolins from the brain. Differential expression of caveolin-1-2 and -3 in brain endothelial and astroglial cell types","volume":"804","author":"Ikezu","year":"1998","journal-title":"Brain Res"},{"key":"10.1086\/302172_bib17","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1073\/pnas.92.5.1381","article-title":"Reduction of caveolin and caveolae in oncogenically transformed cells","volume":"92","author":"Koleske","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib18","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0698-730","article-title":"A detergent-insoluble membrane compartment contains A-beta in vivo","volume":"4","author":"Lee","year":"1998","journal-title":"Nat Med"},{"key":"10.1086\/302172_bib19","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/sj.onc.1201661","article-title":"Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells","volume":"16","author":"Lee","year":"1998","journal-title":"Oncogene"},{"key":"10.1086\/302172_bib20","doi-asserted-by":"crossref","first-page":"29182","DOI":"10.1074\/jbc.271.46.29182","article-title":"Src tyrosine kinases, G alpha subunits and H-Ras share a common membrane-anchored scaffolding protein, caveolin: caveolin binding negatively regulates the auto-activation of Src tyrosine kinases","volume":"271","author":"Li","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(98)00945-4","article-title":"Mutational analysis of caveolin-induced vesicle formation: expression of caveolin-1 recruits caveolin-2 to caveolae membranes","volume":"434","author":"Li","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib22","doi-asserted-by":"crossref","first-page":"28647","DOI":"10.1074\/jbc.271.45.28647","article-title":"Baculovirus-based expression of mammalian caveolin in Sf21 insect cells: a model system for the biochemical and morphological study of caveolar biogenesis","volume":"271","author":"Li","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0962-8924(94)90114-7","article-title":"Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis","volume":"4","author":"Lisanti","year":"1994","journal-title":"Trends Cell Biol"},{"key":"10.1086\/302172_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.126.1.111","article-title":"Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease","volume":"126","author":"Lisanti","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1086\/302172_bib25","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1074\/jbc.272.11.7211","article-title":"Organized endothelial cell signal transduction in caveolae","volume":"272","author":"Liu","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib26","doi-asserted-by":"crossref","first-page":"13666","DOI":"10.1073\/pnas.94.25.13666","article-title":"PDGF activates MAP kinase in isolated caveolae","volume":"94","author":"Liu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/hmg\/7.5.871","article-title":"Caveolin-3 in muscular dystrophy","volume":"7","author":"McNally","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1086\/302172_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng0498-365","article-title":"Mutations in the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy","volume":"18","author":"Minetti","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/302172_bib29","doi-asserted-by":"crossref","first-page":"33416","DOI":"10.1074\/jbc.272.52.33416","article-title":"Caveolin interaction with protein kinase C: isoenzyme-dependent regulation of kinase activity by the caveolin-scaffolding domain peptide","volume":"272","author":"Oka","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib30","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1074\/jbc.273.10.5419","article-title":"Caveolins, a family of scaffolding proteins for organizing \u201cpreassembled signaling complexes\u201d at the plasma membrane","volume":"273","author":"Okamoto","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0955-0674(96)80033-0","article-title":"Caveolae and caveolins","volume":"8","author":"Parton","year":"1996","journal-title":"Curr Opin Cell Biol"},{"key":"10.1086\/302172_bib32","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0022-5347(01)67297-5","article-title":"c-met proto-oncogene expression in benign and malignant human prostate tissues","volume":"154","author":"Pisters","year":"1995","journal-title":"J Urol"},{"key":"10.1086\/302172_bib33","first-page":"467","article-title":"A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP","volume":"1224","author":"Rubin","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1086\/302172_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1101\/SQB.1994.059.01.060","article-title":"RNA Genetics of breast cancer: maspin as a paradigm","volume":"59","author":"Sager","year":"1994","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"10.1086\/302172_bib36","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1073\/pnas.92.20.9407","article-title":"Oligomeric structure of caveolin: implications for caveolae membrane organization","volume":"92","author":"Sargiacomo","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib35","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.122.4.789","article-title":"Signal transducing molecules and GPI-linked proteins form a caveolin-rich insoluble complex in MDCK cells","volume":"122","author":"Sargiacomo","year":"1993","journal-title":"J Cell Biol"},{"key":"10.1086\/302172_bib37","doi-asserted-by":"crossref","first-page":"29337","DOI":"10.1074\/jbc.272.46.29337","article-title":"Cell-type and tissue-specific expression of caveolin-2: caveolins 1 and 2 co-localize and form a stable hetero-oligomeric complex in vivo","volume":"272","author":"Scherer","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib39","doi-asserted-by":"crossref","first-page":"20698","DOI":"10.1074\/jbc.272.33.20698","article-title":"Association of phosphofructokinase-M with caveolin-3 in differentiated skeletal myotubes: dynamic regulation by extra-cellular glucose and intracellular metabolites","volume":"272","author":"Scherer","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib38","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1083\/jcb.127.5.1233","article-title":"Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles","volume":"127","author":"Scherer","year":"1994","journal-title":"J Cell Biol"},{"key":"10.1086\/302172_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1073\/pnas.93.1.131","article-title":"Identification, sequence and expression of caveolin-2 defines a caveolin gene family","volume":"93","author":"Scherer","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib41","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1073\/pnas.95.11.6460","article-title":"Cholesterol depletion inhibits the generation of beta-amyloid in hippo-campal neurons","volume":"95","author":"Simons","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib42","doi-asserted-by":"crossref","first-page":"10104","DOI":"10.1073\/pnas.92.22.10104","article-title":"A detergent-free method for purifying caveolae membrane from tissue culture cells","volume":"92","author":"Smart","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302172_bib43","doi-asserted-by":"crossref","first-page":"9690","DOI":"10.1074\/jbc.271.16.9690","article-title":"Copurification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains: detergent free purification of caveolae microdomains","volume":"271","author":"Song","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib44","doi-asserted-by":"crossref","first-page":"15160","DOI":"10.1074\/jbc.271.25.15160","article-title":"Expression of caveolin-3 in skeletal, cardiac and smooth muscle cells: caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins","volume":"271","author":"Song","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib45","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1074\/jbc.272.4.2437","article-title":"Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans: implications for the molecular evolution of mammalian caveolin genes","volume":"272","author":"Tang","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib46","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1074\/jbc.271.4.2255","article-title":"Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle","volume":"271","author":"Tang","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib47","doi-asserted-by":"crossref","first-page":"26962","DOI":"10.1074\/jbc.273.41.26962","article-title":"Caveolin is an activator of insulin receptor signaling","volume":"273","author":"Yamamoto","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1086\/302172_bib48","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0014-5793(98)01354-4","article-title":"Upregulation of caveolin-1 and caveolae organelles in Taxol-resistant A549 cells","volume":"439","author":"Yang","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/302172_bib49","first-page":"1873","article-title":"Elevated expression of caveolin is associated with prostate and breast cancer","volume":"4","author":"Yang","year":"1998","journal-title":"Clin Cancer Res"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707616012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707616012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T13:25:00Z","timestamp":1554989100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707616012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0002929707616012"],"URL":"https:\/\/doi.org\/10.1086\/302172","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}