{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:46:25Z","timestamp":1791315985197,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,3,1]],"date-time":"1999-03-01T00:00:00Z","timestamp":920246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":5254,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[1999,3]]},"DOI":"10.1086\/302292","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:47:41Z","timestamp":1027694861000},"page":"739-746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":186,"title":["Genomic Structure of the Canalicular Multispecific Organic Anion\u2013Transporter Gene (MRP2\/cMOAT) and Mutations in the ATP-Binding\u2013Cassette Region in Dubin-Johnson Syndrome"],"prefix":"10.1016","volume":"64","author":[{"given":"Satoshi","family":"Toh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morimasa","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Uchiumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Horie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Sakisaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiko","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/302292_bib1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng0397-236","article-title":"A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy","volume":"15","author":"Allikmets","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/302292_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev.bi.50.070181.002025","article-title":"Organization and expression of eucaryotic split genes coding for proteins","volume":"50","author":"Breathnach","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"10.1086\/302292_bib3","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1074\/jbc.271.25.15091","article-title":"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats","volume":"271","author":"B\u00fcchler","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302292_bib4","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1360704","article-title":"Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell","volume":"258","author":"Cole","year":"1992","journal-title":"Science"},{"key":"10.1086\/302292_bib5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/scbi.1997.0070","article-title":"Function, evolution and structure of multidrug resistance protein (MRP)","volume":"8","author":"Deeley","year":"1997","journal-title":"Semin Cancer Biol"},{"key":"10.1086\/302292_bib6","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/BF00211022","article-title":"Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients","volume":"94","author":"D\u00f6rk","year":"1994","journal-title":"Hum Genet"},{"key":"10.1086\/302292_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-195409000-00001","article-title":"Chronic idiopathic jaundice with unidentified pigment in liver cells: new clinico-pathologic entity with report of 12 cases","volume":"33","author":"Dubin","year":"1954","journal-title":"Medicine"},{"key":"10.1086\/302292_bib8","doi-asserted-by":"crossref","first-page":"S242","DOI":"10.1111\/j.1440-1746.1997.tb00507.x","article-title":"Drug-induced hepatic injury","volume":"12","author":"Farrell","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1086\/302292_bib9","first-page":"147","article-title":"Diagnostic and pathogenetic implications of urinary coproporphyrin excretion in the Dubin-Johnson syndrome","volume":"37","author":"Frank","year":"1990","journal-title":"Hepatogastroenterology"},{"key":"10.1086\/302292_bib10","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1146\/annurev.ge.29.120195.003135","article-title":"Genetic analysis of the multidrug transporter","volume":"29","author":"Gottesman","year":"1995","journal-title":"Annu Rev Genet"},{"key":"10.1086\/302292_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1006\/geno.1997.4950","article-title":"Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA","volume":"45","author":"Grant","year":"1997","journal-title":"Genomics"},{"key":"10.1086\/302292_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.cb.08.110192.000435","article-title":"ABC transporters: from microorganisms to man","volume":"8","author":"Higgins","year":"1992","journal-title":"Annu Rev Cell Biol"},{"key":"10.1086\/302292_bib13","doi-asserted-by":"crossref","first-page":"23623","DOI":"10.1074\/jbc.272.38.23623","article-title":"Membrane topology of the multidrug resistance protein (MRP): a study of glycosylation-site mutants reveals an extracytosolic NH2 terminus","volume":"272","author":"Hipfner","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1086\/302292_bib14","first-page":"G16","article-title":"Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR","volume":"272","author":"Ito","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1086\/302292_bib15","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hep.510230519","article-title":"Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome","volume":"23","author":"Kartenbeck","year":"1996","journal-title":"Hepatology"},{"key":"10.1086\/302292_bib16","first-page":"787","article-title":"Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2","volume":"378","author":"Keppler","year":"1997","journal-title":"Biol Chem"},{"key":"10.1086\/302292_bib18","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1073\/pnas.87.9.3557","article-title":"Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR\u2212) rats with conjugated hyperbilirubinemia","volume":"87","author":"Kitamura","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302292_bib19","first-page":"378","article-title":"Clinical and genetic studies on Dubin-Johnson syndrome in a cluster area in Japan","volume":"18","author":"Kondo","year":"1974","journal-title":"Jpn J Hum Genet"},{"key":"10.1086\/302292_bib20","first-page":"3537","article-title":"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines","volume":"57","author":"Kool","year":"1997","journal-title":"Cancer Res"},{"key":"10.1086\/302292_bib21","doi-asserted-by":"crossref","first-page":"9675","DOI":"10.1074\/jbc.271.16.9675","article-title":"Multidrug resistance protein (MRP)\u2013mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles: demonstration of glutathione-dependent vincristine transport","volume":"271","author":"Loe","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1086\/302292_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-4157(95)00006-D","article-title":"Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport","volume":"1241","author":"Oude Elferink","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1086\/302292_bib23","first-page":"G699","article-title":"ATP-dependent efflux of GSSG and GS-conjugate from isolated rat hepatocytes","volume":"258","author":"Oude Elferink","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1086\/302292_bib24","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.271.5252.1126","article-title":"Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene","volume":"271","author":"Paulusma","year":"1996","journal-title":"Science"},{"key":"10.1086\/302292_bib25","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/hep.510250635","article-title":"A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome","volume":"25","author":"Paulusma","year":"1997","journal-title":"Hepatology"},{"key":"10.1086\/302292_bib26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0022-3565(24)37330-6","article-title":"Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats","volume":"284","author":"Sasabe","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1086\/302292_bib27","first-page":"549","article-title":"Dubin-Johnson syndrome in Israel. I. Clinical, laboratory, and genetic aspects of 101 cases","volume":"39","author":"Shani","year":"1970","journal-title":"QJM"},{"key":"10.1086\/302292_bib28","doi-asserted-by":"crossref","first-page":"952","DOI":"10.7326\/0003-4819-41-5-952","article-title":"Persistent nonhemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells: report of four cases","volume":"41","author":"Sprinz","year":"1954","journal-title":"Ann Intern Med"},{"key":"10.1086\/302292_bib29","doi-asserted-by":"crossref","first-page":"8883","DOI":"10.1021\/bi970553v","article-title":"Alteration of substrate specificity by mutations at the His61 position in predicted transmembrane domain 1 of human MDR1\/P-glycoprotein","volume":"36","author":"Taguchi","year":"1997","journal-title":"Biochemistry"},{"key":"10.1086\/302292_bib30","first-page":"1518","article-title":"Clinical study of the constitutional hyperbilirubinemia in Japan: a nationwide survey between 1970 and 1974 (in Japanese)","volume":"74","author":"Takino","year":"1977","journal-title":"Nippon Shokakibyo Gakkai Zasshi"},{"key":"10.1086\/302292_bib31","first-page":"4124","article-title":"A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation","volume":"56","author":"Taniguchi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1086\/302292_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-5793(96)01478-0","article-title":"Membrane topology distinguishes a subfamily of the ABC (ABC) transporters","volume":"402","author":"Tusnady","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1086\/302292_bib33","series-title":"Human genetics: problems and approaches","author":"Vogel","year":"1997"},{"key":"10.1086\/302292_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/hmg\/7.2.203","article-title":"Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II\/Dubin-Johnson syndrome","volume":"7","author":"Wada","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1086\/302292_bib35","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0092-8674(93)90353-R","article-title":"Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis","volume":"73","author":"Welsh","year":"1993","journal-title":"Cell"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761711X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761711X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:13:57Z","timestamp":1762078437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292970761711X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,3]]}},"alternative-id":["S000292970761711X"],"URL":"https:\/\/doi.org\/10.1086\/302292","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[1999,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic Structure of the Canalicular Multispecific Organic Anion\u2013Transporter Gene (MRP2\/cMOAT) and Mutations in the ATP-Binding\u2013Cassette Region in Dubin-Johnson Syndrome","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1086\/302292","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}