{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T07:49:36Z","timestamp":1773733776576,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":5132,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1086\/302441","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:47:41Z","timestamp":1027694861000},"page":"252-254","source":"Crossref","is-referenced-by-count":54,"title":["Highly Skewed X-Chromosome Inactivation Is Associated with Idiopathic Recurrent Spontaneous Abortion"],"prefix":"10.1016","volume":"65","author":[{"given":"Mark C.","family":"Lanasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Allen","family":"Hogge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Kubik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Blancato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric P.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1086\/302441_bib1","first-page":"1101","article-title":"Genetic control of X inactivation and processes leading to X-inactivation skewing","volume":"58","author":"Belmont","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302441_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V88.1.59.59","article-title":"Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age","volume":"88","author":"Busque","year":"1996","journal-title":"Blood"},{"key":"10.1086\/302441_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2141.1997.2573078.x","article-title":"Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age","volume":"98","author":"Gale","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1086\/302441_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1097\/00003081-199409000-00016","article-title":"Recurrent miscarriage: epidemiologic factors, definitions, and incidence","volume":"37","author":"Hatasaka","year":"1994","journal-title":"Clin Obstet Gynecol"},{"key":"10.1086\/302441_bib5","series-title":"Human genetics: problems and approaches","author":"Motulsky","year":"1997"},{"key":"10.1086\/302441_bib6","first-page":"1111","article-title":"Heritability of X chromosome-inactivation phenotype in a large family","volume":"58","author":"Naumova","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302441_bib7","first-page":"989","article-title":"Detection of new paternal dystrophin gene mutations in isolated cases of dystrophinopathy in females","volume":"54","author":"Pegoraro","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302441_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1086\/513901","article-title":"Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28","volume":"61","author":"Pegoraro","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302441_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng1197-353","article-title":"A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation","volume":"17","author":"Plenge","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/302441_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0015-0282(16)58382-4","article-title":"Frequency of factors associated with habitual abortion in 197 couples","volume":"66","author":"Stephenson","year":"1996","journal-title":"Fertil Steril"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707637501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707637501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T19:08:15Z","timestamp":1682190495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707637501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["S0002929707637501"],"URL":"https:\/\/doi.org\/10.1086\/302441","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}