{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:46:59Z","timestamp":1761580019075},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4888,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1086\/302828","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:47:54Z","timestamp":1027694874000},"page":"922-932","source":"Crossref","is-referenced-by-count":82,"title":["Fine Mapping of the Chromosome 12 Late-Onset Alzheimer Disease Locus: Potential Genetic and Phenotypic Heterogeneity"],"prefix":"10.1016","volume":"66","author":[{"given":"W.K.","family":"Scott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Grubber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Conneally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.W.","family":"Small","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Hulette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.K.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Roses","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Pericak-Vance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1086\/302828_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/1243","article-title":"Alpha-2 macroglobulin is genetically associated with Alzheimer disease","volume":"19","author":"Blacker","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib2","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2105\/AJPH.88.9.1337","article-title":"Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset","volume":"88","author":"Brookmeyer","year":"1998","journal-title":"Am J Public Health"},{"key":"10.1086\/302828_bib3","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/archneur.1997.00550220087019","article-title":"Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease","volume":"54","author":"Clatworthy","year":"1997","journal-title":"Arch Neurol"},{"key":"10.1086\/302828_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1086\/302828_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/6002","article-title":"Loci on chromosome 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans","volume":"21","author":"Cox","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/8724","article-title":"Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK","volume":"22","author":"Dow","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1086\/301780","article-title":"Using neural networks as an aid in the determination of disease status: comparison of clinical diagnosis to neural-network predictions in a pedigree with autosomal dominant limb-girdle muscular dystrophy","volume":"62","author":"Falk","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302828_bib9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(97)00634-4","article-title":"No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample","volume":"233","author":"Fallin","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1086\/302828_bib10","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1086\/302828_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/(SICI)1098-2272(1999)17:1<51::AID-GEPI4>3.0.CO;2-V","article-title":"Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis","volume":"17","author":"Feakes","year":"1999","journal-title":"Genet Epidemiol"},{"key":"10.1086\/302828_bib12","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1086\/302828_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1001\/archfami.8.4.347","article-title":"Alzheimer disease: report of the Council on Scientific Affairs","volume":"8","author":"Guttman","year":"1999","journal-title":"Arch Fam Med"},{"key":"10.1086\/302828_bib14","series-title":"Alzheimer's disease: advances in clinical and basic research","first-page":"221","article-title":"Inheritance of multiple loci in familial Alzheimer disease","author":"Haines","year":"1993"},{"key":"10.1086\/302828_bib15","series-title":"The ASPEX package: affected sib-pair exclusion mapping","author":"Hinds","year":"1998"},{"key":"10.1086\/302828_bib16","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1212\/WNL.50.6.1905","article-title":"Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease","volume":"50","author":"Hollenbach","year":"1998","journal-title":"Neurology"},{"key":"10.1086\/302828_bib17","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1212\/WNL.45.11.1991","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease","volume":"45","author":"Hulette","year":"1995","journal-title":"Neurology"},{"key":"10.1086\/302828_bib18","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease","volume":"56","author":"Hyman","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1086\/302828_bib19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(98)00141-4","article-title":"Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene","volume":"244","author":"Kamboh","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1086\/302828_bib20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1212\/WNL.49.1.56","article-title":"Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease","volume":"49","author":"Kang","year":"1997","journal-title":"Neurology"},{"key":"10.1086\/302828_bib21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/hmg\/8.2.237","article-title":"A full genome scan for late onset Alzheimer's disease","volume":"8","author":"Kehoe","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/302828_bib22","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1086\/301592","article-title":"Allele-sharing models: LOD scores and accurate linkage tests","volume":"61","author":"Kong","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302828_bib23","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302828_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0304-3940(97)13381-X","article-title":"Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population","volume":"222","author":"Lendon","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1086\/302828_bib25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1086\/302828_bib26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000022816","article-title":"Multi-locus nonparametric linkage analysis of complex trait loci with neural networks","volume":"48","author":"Lucek","year":"1998","journal-title":"Hum Hered"},{"key":"10.1086\/302828_bib27","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1212\/WNL.47.5.1113","article-title":"Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB International Workshop","volume":"47","author":"McKeith","year":"1996","journal-title":"Neurology"},{"key":"10.1086\/302828_bib28","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1086\/302828_bib29","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1086\/302828_bib30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/ng1295-402","article-title":"The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance","volume":"11","author":"O'Connell","year":"1995","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib31","series-title":"Analysis of human genetic linkage","author":"Ott","year":"1999"},{"key":"10.1086\/302828_bib32","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late-onset familial Alzheimer disease: evidence for a new locus on chromosome 12","volume":"278","author":"Pericak-Vance","year":"1997","journal-title":"JAMA"},{"key":"10.1086\/302828_bib33","first-page":"1034","article-title":"Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage","volume":"48","author":"Pericak-Vance","year":"1991","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302828_bib34","first-page":"A240","article-title":"Development of a data coordinating center (DCC): data quality control for complex disease studies","volume":"63","author":"Rimmler","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302828_bib35","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1086\/302828_bib36","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jama.280.7.614","article-title":"Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity","volume":"280","author":"Rogaeva","year":"1998","journal-title":"JAMA"},{"key":"10.1086\/302828_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/8729","article-title":"An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease","volume":"22","author":"Rogaeva","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/8726","article-title":"Alpha-2 macroglobulin gene and Alzheimer disease","volume":"22","author":"Rudrasingham","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/302828_bib39","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele \u03b54 with late-onset familial and sporadic Alzheimer's disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1086\/302828_bib40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.281.6.513","article-title":"Further evidence linking late-onset Alzheimer disease with chromosome 12","volume":"281","author":"Scott","year":"1999","journal-title":"JAMA"},{"key":"10.1086\/302828_bib41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s100480050026","article-title":"No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease","volume":"1","author":"Scott","year":"1998","journal-title":"Neurogenetics"},{"key":"10.1086\/302828_bib42","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1086\/302828_bib43","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302828_bib44","series-title":"Approaches to gene mapping in complex human diseases","first-page":"213","article-title":"Methods of genotyping","author":"Vance","year":"1998"},{"key":"10.1086\/302828_bib45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0304-3940(97)00304-2","article-title":"Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease","volume":"227","author":"Wavrant-DeVrieze","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1086\/302828_bib46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/bbrc.1993.1423","article-title":"Apolipoprotein E: binding to soluble Alzheimer beta-amyloid","volume":"192","author":"Wisniewski","year":"1993","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1086\/302828_bib47","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jama.280.7.619","article-title":"Genetic studies on chromosome 12 in late-onset Alzheimer disease","volume":"280","author":"Wu","year":"1998","journal-title":"JAMA"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707640191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707640191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T13:28:17Z","timestamp":1554989297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707640191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["S0002929707640191"],"URL":"https:\/\/doi.org\/10.1086\/302828","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}