{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:33:04Z","timestamp":1789212784221,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4857,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1086\/302853","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:47:54Z","timestamp":1027709274000},"page":"1259-1272","source":"Crossref","is-referenced-by-count":259,"title":["BRCA1 and BRCA2 Mutation Analysis of 208 Ashkenazi Jewish Women with Ovarian Cancer"],"prefix":"10.1016","volume":"66","author":[{"given":"Roxana","family":"Moslehi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Karlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fishman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Risch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbie","family":"Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smotkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda","family":"Ben-David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacalyn","family":"Rosenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Warner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Brunet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Narod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/302853_bib1","first-page":"505","article-title":"The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women","volume":"60","author":"Abeliovich","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/cncr.2820710212","article-title":"Genetic epidemiology of epithelial ovarian cancer","volume":"71","author":"Amos","year":"1993","journal-title":"Cancer"},{"key":"10.1086\/302853_bib3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/gyno.1997.4844","article-title":"High frequency of BRCA1 and BRCA2 germline mutations in Ashkenazi Jewish ovarian cancer patients, regardless of family history","volume":"67","author":"Beller","year":"1997","journal-title":"Gynecol Oncol"},{"key":"10.1086\/302853_bib4","first-page":"444","article-title":"Clinical and pathologic features of hereditary ovarian cancers associated with germline mutations of BRCA1 or BRCA2.","volume":"72","author":"Boyd","year":"1999","journal-title":"Gynecol Oncol"},{"key":"10.1086\/302853_bib5","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/jnci\/91.15.1310","article-title":"Cancer risks in BRCA2 mutation carriers","volume":"91","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1086\/302853_bib6","first-page":"1256","article-title":"Survival rates in BRCA1 carriers with ovarian cancer","volume":"336","author":"Brunet","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1086\/302853_bib7","first-page":"265","article-title":"Breast and ovarian cancer incidence in BRCA1 mutation carriers","volume":"56","author":"Easton","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib8","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(94)91578-4","article-title":"Risks of cancer in BRCA1-mutation carriers","volume":"343","author":"Ford","year":"1994","journal-title":"Lancet"},{"key":"10.1086\/302853_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/ng0197-103","article-title":"Variation of risks of breast and ovarian associated with different germline mutations of the BRCA2 gene","volume":"15","author":"Gayther","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ng1295-428","article-title":"Germline mutations of the BRCA1 gene in breast and ovarian cancer families provide evidence for a genotype-phenotype correlation","volume":"11","author":"Gayther","year":"1995","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib14","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/hmg\/8.5.889","article-title":"Germline BRCA1alterations in a population-based series of ovarian cancer cases","volume":"8","author":"Janezic","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/302853_bib15","first-page":"1059","article-title":"Founder BRCA1 and BRCA2 mutations in Ashkenazi Jews in Israel: frequency and differential penetrance in ovarian cancer and in breast cancer families","volume":"60","author":"Levy-Lehad","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib16","first-page":"1255","article-title":"BRCA1 mutations and survival in women with ovarian cancer","volume":"336","author":"Modan","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1086\/302853_bib17","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1001\/jama.1996.03540220047029","article-title":"High frequency of BRCA1 185delAG mutation in ovarian cancer in Israel","volume":"276","author":"Modan","year":"1996","journal-title":"JAMA"},{"key":"10.1086\/302853_bib18","first-page":"1250","article-title":"Frequency of the BRCA1 185delAG mutation among Jewish women with ovarian cancer and matched population controls","volume":"56","author":"Muto","year":"1996","journal-title":"Cancer Res"},{"key":"10.1086\/302853_bib19","first-page":"957","article-title":"Genetic heterogeneity of breast-ovarian cancer revisited","volume":"57","author":"Narod","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib20","first-page":"254","article-title":"An evaluation of genetic heterogeneity in 145 breast-ovarian cancer families","volume":"56","author":"Narod","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302853_bib21","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0140-6736(93)92468-9","article-title":"Increasing incidence of breast cancer in family with BRCA1 mutation","volume":"341","author":"Narod","year":"1993","journal-title":"Lancet"},{"key":"10.1086\/302853_bib22","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1002\/1097-0142(19941015)74:8<2341::AID-CNCR2820740819>3.0.CO;2-Z","article-title":"Hereditary and familial ovarian cancer in Southern Ontario","volume":"74","author":"Narod","year":"1994","journal-title":"Cancer"},{"key":"10.1086\/302853_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng1096-188","article-title":"The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%","volume":"14","author":"Oddoux","year":"1996","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng0597-17","article-title":"Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients","volume":"16","author":"Ozcelik","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib26","volume":"vol 7","author":"Parkin","year":"1997"},{"key":"10.1086\/302853_bib28","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/jnci\/91.17.1475","article-title":"Reduction in breast cancer risk following bilateral prophylactic mastectomy in BRCA1 carriers","volume":"91","author":"Rebbeck","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"10.1086\/302853_bib30","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/jnci\/90.23.1774","article-title":"Hormonal etiology of epithelial ovarian cancer with a hypothesis concerning the role of androgens and progesterone","volume":"90","author":"Risch","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1086\/302853_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/ng1096-185","article-title":"Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2.","volume":"14","author":"Roa","year":"1996","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM199611073351901","article-title":"Clinical and pathological features of ovarian cancer in women with germ-line mutations of BRCA1.","volume":"335","author":"Rubin","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1086\/302853_bib33","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0002-9378(98)70476-4","article-title":"BRCA1, BRCA2 and hereditary nonpolyposis colorectal cancer gene mutations in an unselected ovarian cancer population. Relationship to family history and implications for genetic testing","volume":"178","author":"Rubin","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1086\/302853_bib36","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1056\/NEJM199704173361602","article-title":"Contribution of BRCA1 mutations to ovarian cancer","volume":"336","author":"Stratton","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1086\/302853_bib37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/ng1095-198","article-title":"The carrier frequency of the BRCA1 185delAG mutation is approximately 1 percent in Ashkenazi Jewish individuals","volume":"11","author":"Struewing","year":"1995","journal-title":"Nat Genet"},{"key":"10.1086\/302853_bib38","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1086\/302853_bib39","first-page":"33","article-title":"Prophylactic oophorectomy in inherited breast\/ovarian cancer families","volume":"17","author":"Struewing","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"10.1086\/302853_bib40","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nm1196-1179","article-title":"Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families","volume":"2","author":"Tonin","year":"1996","journal-title":"Nat Med"},{"key":"10.1086\/302853_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/aje\/148.7.623","article-title":"The kin-cohort study for estimating penetrance","volume":"148","author":"Wacholder","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1086\/302853_bib42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/jnci\/91.14.1241","article-title":"Prevalence and penetrance of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish women with breast cancer","volume":"91","author":"Warner","year":"1999","journal-title":"J Natl Cancer Inst"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707601554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707601554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:28:04Z","timestamp":1555003684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707601554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0002929707601554"],"URL":"https:\/\/doi.org\/10.1086\/302853","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}