{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:29:59Z","timestamp":1791890999451,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4857,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1086\/302866","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:47:54Z","timestamp":1027709274000},"page":"1443-1448","source":"Crossref","is-referenced-by-count":130,"title":["Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome Maps to Chromosome 15q"],"prefix":"10.1016","volume":"66","author":[{"given":"Howard B.","family":"Yeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noralane M.","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/302866_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/rheumatology\/27.4.306","article-title":"The role of HLA-B27 in arthritis","volume":"27","author":"Archer","year":"1988","journal-title":"Br J Rheumatol"},{"key":"10.1086\/302866_bib2","doi-asserted-by":"crossref","first-page":"17662","DOI":"10.1016\/S0021-9258(19)47422-X","article-title":"Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP): retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vivo","volume":"266","author":"Astrom","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1086\/302866_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/ard.53.1.64","article-title":"Arthritis associated with hidradenitis suppurativa","volume":"53","author":"Bhalla","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"10.1086\/302866_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0300-2977(95)00093-3","article-title":"Familial occurrence and inheritance studies in inflammatory bowel disease","volume":"48","author":"Binder","year":"1996","journal-title":"Neth J Med"},{"key":"10.1086\/302866_bib5","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000249709","article-title":"Pyoderma gangrenosum associated with selective hereditary IgA deficiency","volume":"168","author":"Bundino","year":"1984","journal-title":"Dermatologica"},{"key":"10.1086\/302866_bib6","first-page":"61","article-title":"Pyoderma gangrenosum\u2014a literature review","volume":"21","author":"Callen","year":"1978","journal-title":"Cutis"},{"key":"10.1086\/302866_bib7","first-page":"167","article-title":"The lymphocyte chemoattractant factor","volume":"125","author":"Center","year":"1995","journal-title":"J Lab Clin Med"},{"key":"10.1086\/302866_bib8","first-page":"108","article-title":"Sibling pairs affected by chronic arthritis of childhood: evidence for a genetic predisposition","volume":"12","author":"Clemens","year":"1985","journal-title":"J Rheumatol"},{"key":"10.1086\/302866_bib9","first-page":"336","article-title":"Acne rheumatism: report of a case","volume":"8","author":"Cros","year":"1981","journal-title":"J Rheumatol"},{"key":"10.1086\/302866_bib11","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1073\/pnas.91.11.5109","article-title":"Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression","volume":"91","author":"Cruikshank","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302866_bib10","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.4049\/jimmunol.146.9.2928","article-title":"Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes","volume":"146","author":"Cruikshank","year":"1991","journal-title":"J Immunol"},{"key":"10.1086\/302866_bib12","first-page":"195","article-title":"Acute arthritis during isotretinoin treatment for acne conglobata [letter]","volume":"194","author":"De Francesco","year":"1997","journal-title":"Dermatology"},{"key":"10.1086\/302866_bib13","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1053\/gast.1996.v110.pm8964393","article-title":"Long-term evolution of gut inflammation in patients with spondyloarthropathy","volume":"110","author":"De Vos","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1086\/302866_bib14","first-page":"228","article-title":"Acute monoarthritis in a patient under isotretinoin [letter]","volume":"63","author":"Dubourg","year":"1996","journal-title":"Rev Rhum Engl Ed"},{"key":"10.1086\/302866_bib15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/1523-1747.ep12499896","article-title":"Differential regulation of retinoic acid receptors and binding proteins in human skin","volume":"98","author":"Elder","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1086\/302866_bib16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0014-4827(92)90387-N","article-title":"The molecular cloning and expression two CRABP cDNAs from human skin","volume":"198","author":"Eller","year":"1992","journal-title":"Exp Cell Res"},{"key":"10.1086\/302866_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/00325481.1989.11704368","article-title":"Arthritis and the gut","volume":"86","author":"Finch","year":"1989","journal-title":"Postgrad Med"},{"key":"10.1086\/302866_bib18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1365-2133.1996.d01-1088.x","article-title":"A review of skin ageing and its medical therapy","volume":"135","author":"Gilchrest","year":"1996","journal-title":"Br J Dermatol"},{"key":"10.1086\/302866_bib19","first-page":"1149","article-title":"[Postoperative and post-traumatic familial pyoderma gangrenosum.]","volume":"115","author":"Girardin","year":"1988","journal-title":"Ann Dermatol Venereol"},{"key":"10.1086\/302866_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0950-3579(05)80193-1","article-title":"Psoriatic arthritis","volume":"9","author":"Gladman","year":"1995","journal-title":"Baillieres Clin Rheumatol"},{"key":"10.1086\/302866_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00005792-198003000-00003","article-title":"Pyoderma gangrenosum: clinical and laboratory findings in 15 patients with special reference to polyarthritis","volume":"59","author":"Holt","year":"1980","journal-title":"Medicine (Baltimore)"},{"key":"10.1086\/302866_bib22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1542\/peds.56.4.570","article-title":"\u201cStreaking leukocyte factor,\u201d arthritis, and pyoderma gangrenosum","volume":"56","author":"Jacobs","year":"1975","journal-title":"Pediatrics"},{"key":"10.1086\/302866_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0049-0172(91)90020-Z","article-title":"Musculoskeletal syndromes associated with acne","volume":"20","author":"Knitzer","year":"1991","journal-title":"Semin Arthritis Rheum"},{"key":"10.1086\/302866_bib24","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.81.11.3443","article-title":"Strategies for multilocus linkage analysis in humans","volume":"81","author":"Lathrop","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/302866_bib25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0025-6196(11)63565-9","article-title":"A new autosomal dominant disorder of pyogenic sterile arthritis, pyoderma gangrenosum, and acne: PAPA syndrome","volume":"72","author":"Lindor","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"10.1086\/302866_bib26","first-page":"459","article-title":"Late onset pauciarticular juvenile chronic arthritis: relation to gut inflammation","volume":"14","author":"Mielants","year":"1987","journal-title":"J Rheumatol"},{"key":"10.1086\/302866_bib27","first-page":"466","article-title":"HLA antigens in seronegative spondylarthropathies. Reactive arthritis and arthritis in ankylosing spondylitis: relation to gut inflammation","volume":"14","author":"Mielants","year":"1987","journal-title":"J Rheumatol"},{"key":"10.1086\/302866_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/ard.47.11.893","article-title":"Immunoglobulin allotype Gm(1,2;21) in ankylosing spondylitis with peripheral arthritis","volume":"47","author":"Mierau","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1086\/302866_bib29","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3109\/03009748509165506","article-title":"HLA antigen frequencies in juvenile chronic arthritis","volume":"14","author":"Morling","year":"1985","journal-title":"Scand J Rheumatol"},{"key":"10.1086\/302866_bib30","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0960-8966(97)00448-3","article-title":"Prenatal diagnosis in merosin-deficient congenital muscular dystrophy","volume":"7","author":"Naom","year":"1997","journal-title":"Neuromuscul Disord"},{"key":"10.1086\/302866_bib31","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/hmg\/5.10.1679","article-title":"susceptibility locus for inflammatory bowl disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis","volume":"5","author":"Ohmen","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1086\/302866_bib32","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/S0140-6736(05)66204-6","article-title":"Susceptibility loci in inflammatory bowel disease [letter]","volume":"348","author":"Parkes","year":"1996","journal-title":"Lancet"},{"key":"10.1086\/302866_bib33","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.nu.16.070196.001353","article-title":"Regulation of metabolism by retinoic acid and its nuclear receptors","volume":"16","author":"Pfahl","year":"1996","journal-title":"Annu Rev Nutr"},{"key":"10.1086\/302866_bib34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/rheumatology\/30.5.387","article-title":"Lytic bone lesions and polyarthritis associated with acne fulminans","volume":"30","author":"Piazza","year":"1991","journal-title":"Br J Rheumatol"},{"key":"10.1086\/302866_bib35","first-page":"173","article-title":"Pyoderma gangrenosum: a review of 86 patients","volume":"55","author":"Powell","year":"1985","journal-title":"Q J Med"},{"key":"10.1086\/302866_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1001\/archderm.1989.01670130059007","article-title":"Present status of pyoderma gangrenosum: review of 21 cases","volume":"125","author":"Prystowsky","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1086\/302866_bib37","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/ard.49.4.225","article-title":"Genes associated with rheumatoid arthritis and mild inflammatory arthritis. II. Association of HLA with complement C3 and immunoglobulin Gm allotypes","volume":"49","author":"Puttick","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1086\/302866_bib38","first-page":"684","article-title":"The clinical spectrum of the arthropathy associated with hidradenitis suppurativa and acne conglobata","volume":"20","author":"Rosner","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1086\/302866_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/1523-1747.ep12462785","article-title":"Retinoids and state of differentiation modulate CRABP II gene expression in a skin equivalent","volume":"100","author":"Sanquer","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1086\/302866_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng1096-199","article-title":"Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12","volume":"14","author":"Satsangi","year":"1996","journal-title":"Nat Genet"},{"key":"10.1086\/302866_bib41","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0190-9622(87)70116-9","article-title":"Pyoderma gangrenosum in a kindred: precipitation by surgery or mild physical trauma","volume":"16","author":"Shands","year":"1987","journal-title":"J Am Acad Dermatol"},{"key":"10.1086\/302866_bib42","first-page":"315","article-title":"Pyoderma gangrenosum associated with cystic acne and hidradenitis suppurativa coned by add minocycline and sulfasalazine to the treatment regimen","volume":"57","author":"Shenefelt","year":"1996","journal-title":"Cutis"},{"key":"10.1086\/302866_bib43","first-page":"1097","article-title":"Genetic linkage of familial granulomatous inflammatory arthritis, skin rash, and uveitis to chromosome 16","volume":"59","author":"Tromp","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302866_bib44","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ng0493-333","article-title":"A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3","volume":"3","author":"Watkins","year":"1993","journal-title":"Nat Genet"},{"key":"10.1086\/302866_bib45","first-page":"388","article-title":"Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction","volume":"44","author":"Weber","year":"1989","journal-title":"Am J Hum Genet"},{"key":"10.1086\/302866_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0307-742X(21)00586-5","article-title":"Genetic aspects of the spondyloarthropathies","volume":"11","author":"Woodrow","year":"1985","journal-title":"Clin Rheum Dis"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707601748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707601748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T23:00:46Z","timestamp":1682204446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707601748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S0002929707601748"],"URL":"https:\/\/doi.org\/10.1086\/302866","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}