{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:05Z","timestamp":1790255045708,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4674,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2000,10]]},"DOI":"10.1086\/303086","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:47:54Z","timestamp":1027709274000},"page":"976-981","source":"Crossref","is-referenced-by-count":66,"title":["PEX3 Is the Causal Gene Responsible for Peroxisome Membrane Assembly\u2013Defective Zellweger Syndrome of Complementation Group G"],"prefix":"10.1016","volume":"67","author":[{"given":"Kamran","family":"Ghaedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Honsho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Shimozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Fujiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/303086_bib1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1093\/hmg\/4.suppl_1.1791","article-title":"Disorders of peroxisome biogenesis","volume":"4","author":"Braverman","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1086\/303086_bib2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0014-5793(00)01667-7","article-title":"Peroxisome biogenesis and peroxisome biogenesis disorders","volume":"476","author":"Fujiki","year":"2000","journal-title":"FEBS Lett"},{"key":"10.1086\/303086_bib3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1006\/excr.1999.4413","article-title":"Isolation and characterization of novel peroxisome biogenesis-defective Chinese hamster ovary cell mutants using green fluorescent protein","volume":"248","author":"Ghaedi","year":"1999","journal-title":"Exp Cell Res"},{"key":"10.1086\/303086_bib4","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1091\/mbc.11.6.2085","article-title":"The peroxin Pex3p initiates membrane assembly in peroxisome biogenesis","volume":"11","author":"Ghaedi","year":"2000","journal-title":"Mol Biol Cell"},{"key":"10.1086\/303086_bib5","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1086\/302161","article-title":"Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D","volume":"63","author":"Honsho","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/303086_bib6","doi-asserted-by":"crossref","first-page":"24122","DOI":"10.1074\/jbc.273.37.24122","article-title":"Newly identified Chinese hamster ovary cell mutants are defective in biogenesis of peroxisomal membrane vesicles (peroxisomal ghosts), representing a novel complementation group in mammals","volume":"273","author":"Kinoshita","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1086\/303086_bib7","series-title":"The metabolic basis of inherited disease","first-page":"2287","article-title":"Disorders of peroxisome biogenesis","author":"Lazarow","year":"1995"},{"key":"10.1086\/303086_bib8","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1073\/pnas.96.5.2116","article-title":"Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome and potential role in peroxisomal membrane assembly","volume":"96","author":"Matsuzono","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/303086_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1006\/bbrc.2000.2193","article-title":"The human PEX3 gene encoding a peroxisomal assembly protein: genetic organization, positional mapping, and mutation analysis in candidate phenotypes","volume":"268","author":"Muntau","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1086\/303086_bib10","doi-asserted-by":"crossref","first-page":"21703","DOI":"10.1074\/jbc.M000720200","article-title":"The mammalian peroxin Pex5pL, the longer isoform of mobile PTS1-transporter, translocates Pex7p-PTS2 protein complex into peroxisomes via its initial docking site Pex14p","volume":"275","author":"Otera","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1086\/303086_bib11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0022-3476(95)70121-4","article-title":"Peroxisomal assembly defects: clinical, pathologic, and biochemical findings in two patients in a newly identified complementation group","volume":"127","author":"Poulos","year":"1995","journal-title":"J Pediatr"},{"key":"10.1086\/303086_bib12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1083\/jcb.148.5.931","article-title":"PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis","volume":"148","author":"Sacksteder","year":"2000","journal-title":"J Cell Biol"},{"key":"10.1086\/303086_bib13","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/jcp.1041510115","article-title":"Peroxisome assembly mutations in humans: structural heterogeneity in Zellweger syndrome","volume":"151","author":"Santos","year":"1992","journal-title":"J Cell Physiol"},{"key":"10.1086\/303086_bib14","doi-asserted-by":"crossref","first-page":"12593","DOI":"10.1074\/jbc.274.18.12593","article-title":"The peroxin Pex14p: cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis","volume":"274","author":"Shimizu","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1086\/303086_bib16","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1086\/302142","article-title":"Genetic basis of peroxisome-assembly mutants of humans, Chinese hamster ovary cells, and yeast: identification of a new complementation group of peroxisome-biogenesis disorders apparently lacking peroxisomal-membrane ghosts","volume":"63","author":"Shimozawa","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/303086_bib15","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1172\/JCI116063","article-title":"Animal cell mutants represent two complementation groups of peroxisome-defective Zellweger syndrome","volume":"90","author":"Shimozawa","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1086\/303086_bib17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0171-9335(99)80078-8","article-title":"Identification and characterization of the human peroxin PEX3","volume":"78","author":"Soukupova","year":"1999","journal-title":"Eur J Cell Biol"},{"key":"10.1086\/303086_bib18","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1083\/jcb.144.2.255","article-title":"Peroxisome synthesis in the absence of preexisting peroxisomes","volume":"144","author":"South","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1086\/303086_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ng0497-331","article-title":"PEX genes on the rise","volume":"15","author":"Subramani","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/303086_bib20","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1073\/pnas.95.8.4350","article-title":"Human PEX1 cloned by functional complementation on a CHO cell mutant is responsible for peroxisome-deficient Zellweger syndrome of complementation group I","volume":"95","author":"Tamura","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/303086_bib21","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/hmg\/8.9.1673","article-title":"Isolation, characterization, and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants","volume":"8","author":"Toyama","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/303086_bib22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1083\/jcb.110.3.651","article-title":"Isolation and characterization of Chinese hamster ovary cell mutants defective in assembly of peroxisomes","volume":"110","author":"Tsukamoto","year":"1990","journal-title":"J Cell Biol"},{"key":"10.1086\/303086_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.bi.61.070192.001105","article-title":"Biochemistry of peroxisomes","volume":"61","author":"van den Bosch","year":"1992","journal-title":"Annu Rev Biochem"},{"key":"10.1086\/303086_bib24","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1172\/JCI116854","article-title":"Presence of cytoplasmic factors functional in peroxisomal protein import implicates organelle-associated defects in several human peroxisomal disorders","volume":"92","author":"Wendland","year":"1993","journal-title":"J Clin Invest"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707632893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707632893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:25:20Z","timestamp":1555003520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707632893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["S0002929707632893"],"URL":"https:\/\/doi.org\/10.1086\/303086","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}