{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:24:20Z","timestamp":1791354260040,"version":"4.3.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4582,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1086\/316925","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T18:47:54Z","timestamp":1027709274000},"page":"254-260","source":"Crossref","is-referenced-by-count":55,"title":["DFNA25, a Novel Locus for Dominant Nonsyndromic Hereditary Hearing Impairment, Maps to 12q21-24"],"prefix":"10.1016","volume":"68","author":[{"given":"Charles C.","family":"Greene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamella M.","family":"McMillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Kurnool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret I.","family":"Lomax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Burmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marci M.","family":"Lesperance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/316925_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0030-6665(20)33071-1","article-title":"A high risk registry to find congenital deafness","volume":"4","author":"Bergstrom","year":"1971","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1086\/316925_bib2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1086\/302011","article-title":"Comprehensive human genetic maps: individual and sex-specific variation in recombination","volume":"63","author":"Broman","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/316925_bib3","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s003359900552","article-title":"Localization of the bronx waltzer (bv) deafness gene to mouse chromosome 5","volume":"8","author":"Bussoli","year":"1997","journal-title":"Mamm Genome"},{"key":"10.1086\/316925_bib4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1086\/302938","article-title":"Phenotypes of patients with \u201csimple\u201d Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics","volume":"66","author":"Dipple","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/316925_bib5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/jmg.1.2.118","article-title":"Profound childhood deafness","volume":"1","author":"Fraser","year":"1964","journal-title":"J Med Genet"},{"key":"10.1086\/316925_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0378-5955(96)00013-5","article-title":"Identification of genes expressed after noise exposure in the chick basilar papilla","volume":"96","author":"Gong","year":"1996","journal-title":"Hear Res"},{"key":"10.1086\/316925_bib7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00003446-199612000-00003","article-title":"The hearing threshold levels of children at school age","volume":"17","author":"Haapaniemi","year":"1996","journal-title":"Ear Hear"},{"key":"10.1086\/316925_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/387080a0","article-title":"Connexin 26 mutations in hereditary non-syndromic sensorineural deafness","volume":"387","author":"Kelsell","year":"1997","journal-title":"Nature"},{"key":"10.1086\/316925_bib9","series-title":"Genetic and metabolic deafness","first-page":"7","article-title":"Genetic hearing loss with no associated abnormalities","author":"Konigsmark","year":"1976"},{"key":"10.1086\/316925_bib10","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.81.11.3443","article-title":"Strategies for multilocus linkage analysis in humans","volume":"81","author":"Lathrop","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/316925_bib11","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/hmg\/4.10.1967","article-title":"A gene for autosomal dominant nonsyndromic heredity hearing impairment maps to 4p16.3","volume":"4","author":"Lesperance","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1086\/316925_bib12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)00143-4","article-title":"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor","volume":"103","author":"Liedtke","year":"2000","journal-title":"Cell"},{"key":"10.1086\/316925_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0378-5955(00)00139-8","article-title":"Differential display and gene arrays to examine auditory plasticity","volume":"147","author":"Lomax","year":"2000","journal-title":"Hear Res"},{"key":"10.1086\/316925_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.1991.tb19572.x","article-title":"Genetic epidemiology of hearing impairment","volume":"630","author":"Morton","year":"1991","journal-title":"Ann N Y Acad Sci"},{"key":"10.1086\/316925_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0888-7543(91)90356-J","article-title":"Localization of two genes encoding plasma membrane Ca2+-transporting ATPases to human chromosomes 1q25-32 and 12q21-23","volume":"9","author":"Olson","year":"1991","journal-title":"Genomics"},{"key":"10.1086\/316925_bib16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/3840","article-title":"Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis","volume":"20","author":"Richard","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/316925_bib17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0167-4781(96)00022-X","article-title":"A novel zinc finger gene preferentially expressed in the retina and the organ of Corti localizes to human chromosome 12q24.3","volume":"1306","author":"Rivolta","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1086\/316925_bib18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/03005368809077793","article-title":"Threshold of hearing as a function of age and sex for the typical unscreened population","volume":"22","author":"Robinson","year":"1988","journal-title":"Br J Audiol"},{"key":"10.1086\/316925_bib19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6784","article-title":"Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease","volume":"21","author":"Sakuntabhai","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/316925_bib20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.274.5287.540","article-title":"A gene map of the human genome","volume":"274","author":"Schuler","year":"1996","journal-title":"Science"},{"key":"10.1086\/316925_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/hmg\/8.3.439","article-title":"Human cochlear expressed sequence tags provide insight into cochlear gene expression and identify candidate genes for deafness","volume":"8","author":"Skvorak","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/316925_bib22","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/1284","article-title":"Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice","volume":"19","author":"Street","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/316925_bib23","first-page":"758","article-title":"Nonsyndromic hearing impairment: unparalleled heterogeneity","volume":"60","author":"Van Camp","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/316925_bib24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/3845","article-title":"Mutations in the gene encoding gap junction protein \u03b2-3 associated with autosomal dominant hearing impairment","volume":"20","author":"Xia","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/316925_bib25","first-page":"459","article-title":"Improved set of short-tandem-repeat polymorphisms for screening the human genome","volume":"60","author":"Yuan","year":"1997","journal-title":"Am J Hum Genet"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707624938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707624938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T06:27:11Z","timestamp":1621232831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707624938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0002929707624938"],"URL":"https:\/\/doi.org\/10.1086\/316925","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}