{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:36:38Z","timestamp":1792305398805,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4551,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1086\/318185","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T15:01:40Z","timestamp":1027695700000},"page":"495-500","source":"Crossref","is-referenced-by-count":86,"title":["A Second Gene for Otosclerosis, OTSC2, Maps to Chromosome 7q34-36"],"prefix":"10.1016","volume":"68","author":[{"given":"Kris","family":"Van Den Bogaert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Govaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Schatteman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goele","family":"Caethoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.Erwin","family":"Offeciers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Somers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Declau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Coucke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Van","family":"de Heyning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.H.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Van Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/318185_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/cyto.1999.0539","article-title":"Tumour necrosis factor \u03b1 enhances the expression of hydroxyl lyase, cytoplasmic antiproteinase-2 and a dual specificity kinase TTK in human chondrocyte-like cells","volume":"12","author":"Ah-Kim","year":"2000","journal-title":"Cytokine"},{"key":"10.1086\/318185_bib2","first-page":"244","article-title":"\u00dcber der vererbung der heredit\u00e4ren labyrinth-schwerk\u00f6rigkeit und der otosclerose","volume":"11","author":"Albrecht","year":"1922","journal-title":"Arch Ohrenheilk Nas Kehlkopfheilk"},{"key":"10.1086\/318185_bib3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/00016489609137910","article-title":"Measles virus in otosclerosis and the specific immune response of the inner ear","volume":"116","author":"Arnold","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"10.1086\/318185_bib4","first-page":"111","article-title":"A genetic study of otosclerosis in a population living in the north of Tunisia","volume":"36","author":"Ben Arab","year":"1993","journal-title":"Ann Genet"},{"key":"10.1086\/318185_bib5","first-page":"211","article-title":"Otospongiosis as a genetic disease: early detection, medical management, and prevention","volume":"5","author":"Causse","year":"1984","journal-title":"Am J Otol"},{"key":"10.1086\/318185_bib6","first-page":"252","article-title":"Faster sequential genetic linkage computations","volume":"53","author":"Cottingham","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1086\/318185_bib7","series-title":"Genetics and hearing impairment","first-page":"221","article-title":"Otosclerosis","author":"Declau","year":"1996"},{"key":"10.1086\/318185_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/380152a0","article-title":"A comprehensive genetic map of the human genome based on 5,264 microsatellites","volume":"380","author":"Dib","year":"1996","journal-title":"Nature"},{"key":"10.1086\/318185_bib9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1288\/00005537-198001000-00004","article-title":"Medical genetics for the otolaryngologist","volume":"90","author":"Donnell","year":"1980","journal-title":"Laryngoscope"},{"key":"10.1086\/318185_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1096-9926(199710)56:4<233::AID-TERA1>3.0.CO;2-#","article-title":"Effect of retinoic acid on otic capsule chondrogenesis in high-density culture suggests disruption of epithelial-mesenchymal interactions","volume":"56","author":"Frenz","year":"1997","journal-title":"Teratology"},{"key":"10.1086\/318185_bib11","series-title":"Otosclerosis: genetics and surgical rehabilitation","author":"Gapany-Gapanaviscius","year":"1975"},{"key":"10.1086\/318185_bib12","first-page":"426","article-title":"The genetics of otosclerosis: a review","volume":"10","author":"Gordon","year":"1989","journal-title":"Am J Otol"},{"key":"10.1086\/318185_bib13","first-page":"718","article-title":"A new autosomal-dominant locus (DFNA12) is responsible for a nonsyndromic, midfrequency, prelingual and nonprogressive sensorineural hearing loss","volume":"19","author":"Govaerts","year":"1998","journal-title":"Am J Otol"},{"key":"10.1086\/318185_bib101","series-title":"Acoustics-threshold of hearing by air conduction as a function of age and sex for otologically normal persons [publication 7029]","author":"International Organization for Standardization","year":"1984"},{"key":"10.1086\/318185_bib14","first-page":"1","article-title":"Otosclerosis: a genetic and clinical study","volume":"154","author":"Larsson","year":"1960","journal-title":"Acta Otolaryngol (Stockh) (Suppl)"},{"key":"10.1086\/318185_bib15","series-title":"Otosclerosis","first-page":"109","article-title":"Genetic problems in otosclerosis","author":"Larsson","year":"1962"},{"key":"10.1086\/318185_bib16","first-page":"827","article-title":"Polymerase chain reaction amplification of a measles virus sequence from human temporal bone sections with active otosclerosis","volume":"17","author":"McKenna","year":"1996","journal-title":"Am J Otol"},{"key":"10.1086\/318185_bib17","first-page":"202","article-title":"Genetic factors in otosclerosis","volume":"41","author":"Morrison","year":"1967","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1086\/318185_bib18","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1017\/S0022215100072698","article-title":"The inheritance of otosclerosis","volume":"84","author":"Morrison","year":"1970","journal-title":"J Laryngol Otol"},{"key":"10.1086\/318185_bib19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000276627","article-title":"Evidence of measles virus RNA in otosclerotic tissue","volume":"56","author":"Niedermeyer","year":"1994","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"10.1086\/318185_bib20","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0794-390","article-title":"Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping","volume":"7","author":"Reed","year":"1994","journal-title":"Nat Genet"},{"key":"10.1086\/318185_bib21","first-page":"1","article-title":"Fenestration operation for otosclerosis","volume":"79","author":"Shambaugh","year":"1949","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1086\/318185_bib22","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1177\/000348949410301204","article-title":"Statistical analysis of otosclerosis surgery performed by J Marquet","volume":"103","author":"Somers","year":"1994","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1086\/318185_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1017\/S0022215100136989","article-title":"Revision stapes surgery","volume":"111","author":"Somers","year":"1997","journal-title":"J Laryngol Otol"},{"key":"10.1086\/318185_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/hmg\/7.2.285","article-title":"Localization of a gene for otosclerosis to chromosome 15q25-q26","volume":"7","author":"Tomek","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1086\/318185_bib25","doi-asserted-by":"crossref","first-page":"12881","DOI":"10.1074\/jbc.273.21.12881","article-title":"Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3)","volume":"273","author":"Valtavaara","year":"1998","journal-title":"J Biol Chem"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707636209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707636209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:48:42Z","timestamp":1583282922000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707636209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0002929707636209"],"URL":"https:\/\/doi.org\/10.1086\/318185","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}