{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:46:26Z","timestamp":1760852786796},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4217,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1086\/324773","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T17:29:04Z","timestamp":1027704544000},"page":"237-243","source":"Crossref","is-referenced-by-count":47,"title":["Chromosome-12 Mapping of Late-Onset Alzheimer Disease among Caribbean Hispanics"],"prefix":"10.1016","volume":"70","author":[{"given":"R.","family":"Mayeux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.N.","family":"Romas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ciappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.Z.","family":"Rondon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Estevez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Lantigua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tycko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1086\/324773_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0304-3940(98)00734-4","article-title":"Low density lipoprotein receptor related protein gene amplification and 766T polymorphism in astrocytomas","volume":"256","author":"Baum","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1086\/324773_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0304-3940(98)00888-X","article-title":"The polymorphism in exon 3 of the low density lipoprotein receptor- related protein gene is weakly associated with Alzheimer's disease","volume":"259","author":"Beffert","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1086\/324773_bib6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/1243","article-title":"Alpha-2 macroglobulin is genetically associated with Alzheimer disease","volume":"19","author":"Blacker","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/324773_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/archneur.1997.00550220087019","article-title":"Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease","volume":"54","author":"Clatworthy","year":"1997","journal-title":"Arch Neurol"},{"key":"10.1086\/324773_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1212\/WNL.54.2.438","article-title":"Alpha2 macroglobulin and the risk of Alzheimer's disease","volume":"54","author":"Dodel","year":"2000","journal-title":"Neurology"},{"key":"10.1086\/324773_bib9","doi-asserted-by":"crossref","first-page":"4008","DOI":"10.1093\/nar\/19.14.4008","article-title":"\u201cTouchdown\u201d PCR to circumvent spurious priming during gene amplification","volume":"19","author":"Don","year":"1991","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/324773_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1212\/WNL.54.2.433","article-title":"Lack of association of the alpha2-macroglobulin locus on chromosome 12 in AD","volume":"54","author":"Gibson","year":"2000","journal-title":"Neurology"},{"key":"10.1086\/324773_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000484736","article-title":"Relationship estimation in affected sib pair analysis of late-onset diseases","volume":"5","author":"Goring","year":"1997","journal-title":"Eur J Hum Genet"},{"key":"10.1086\/324773_bib12","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1086\/302846","article-title":"Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters","volume":"66","author":"Goring","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/324773_bib13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.0.CO;2-5","article-title":"Rates of dementia in three ethnoracial groups","volume":"14","author":"Gurland","year":"1999","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1086\/324773_bib14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0022-2275(20)43176-1","article-title":"Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI","volume":"31","author":"Hixson","year":"1990","journal-title":"J Lipid Res"},{"key":"10.1086\/324773_bib15","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1212\/WNL.50.6.1905","article-title":"Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease","volume":"50","author":"Hollenbach","year":"1998","journal-title":"Neurology"},{"key":"10.1086\/324773_bib16","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1192\/bjp.140.6.566","article-title":"A new clinical scale for the staging of dementia","volume":"140","author":"Hughes","year":"1982","journal-title":"Br J Psychiatry"},{"key":"10.1086\/324773_bib17","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000154188","article-title":"Linkage analysis in nuclear families. 2. Relationship between affected sib-pair tests and lod score analysis","volume":"44","author":"Knapp","year":"1994","journal-title":"Hum Hered"},{"key":"10.1086\/324773_bib18","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/324773_bib19","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/7.12.1953","article-title":"Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease","volume":"7","author":"Liao","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1086\/324773_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.410370217","article-title":"Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks","volume":"37","author":"Maestre","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1086\/324773_bib21","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1086\/324773_bib22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: a program for identification of genotype incompatibilities in linkage analysis","volume":"63","author":"O'Connell","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/324773_bib23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late-onset familial Alzheimer disease: evidence for a new locus on chromosome 12","volume":"278","author":"Pericak-Vance","year":"1997","journal-title":"JAMA"},{"key":"10.1086\/324773_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1212\/WNL.49.1.44","article-title":"Incidence and prevalence of dementia in a multiethnic cohort of municipal retirees","volume":"49","author":"Perkins","year":"1997","journal-title":"Neurology"},{"key":"10.1086\/324773_bib25","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/archneur.1992.00530290043010","article-title":"Diagnosis of dementia in a heterogeneous population: a comparison of paradigm-based diagnosis and physician's diagnosis","volume":"49","author":"Pittman","year":"1992","journal-title":"Arch Neurol"},{"key":"10.1086\/324773_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000154047","article-title":"Model misspecification and multipoint linkage analysis","volume":"42","author":"Risch","year":"1992","journal-title":"Hum Hered"},{"key":"10.1086\/324773_bib27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jama.280.7.614","article-title":"Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity","volume":"280","author":"Rogaeva","year":"1998","journal-title":"JAMA"},{"key":"10.1086\/324773_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3940(99)00972-6","article-title":"The deletion polymorphism and Val1000Ile in alpha-2-macroglobulin and Alzheimer disease in Caribbean Hispanics","volume":"279","author":"Romas","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1086\/324773_bib29","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.281.6.513","article-title":"Further evidence linking late-onset Alzheimer disease with chromosome 12","volume":"281","author":"Scott","year":"1999","journal-title":"JAMA"},{"key":"10.1086\/324773_bib30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1086\/302828","article-title":"Fine mapping of the chromosome 12 late-onset Alzheimer disease locus: potential genetic and phenotypic heterogeneity","volume":"66","author":"Scott","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/324773_bib31","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1086\/301714","article-title":"A sibship test for linkage in the presence of association: the sib transmission\/disequilibrium test","volume":"62","author":"Spielman","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/324773_bib32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1001\/archneur.1992.00530290035009","article-title":"Diagnosis of dementia in a heterogeneous population: development of a neuropsychological paradigm-based diagnosis of dementia and quantified correction for the effects of education","volume":"49","author":"Stern","year":"1992","journal-title":"Arch Neurol"},{"key":"10.1086\/324773_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1212\/WNL.56.1.49","article-title":"Incidence of AD in African-Americans, Caribbean Hispanics, and Caucasians in northern Manhattan","volume":"56","author":"Tang","year":"2001","journal-title":"Neurology"},{"key":"10.1086\/324773_bib34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1001\/jama.280.7.619","article-title":"Genetic studies on chromosome 12 in late-onset Alzheimer disease","volume":"280","author":"Wu","year":"1998","journal-title":"JAMA"},{"key":"10.1086\/324773_bib35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1212\/WNL.52.4.725","article-title":"Neurobiological correlates of a putative risk allele for Alzheimer's disease on chromosome 12q","volume":"52","author":"Zubenko","year":"1999","journal-title":"Neurology"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761297X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761297X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T05:25:09Z","timestamp":1621229109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292970761297X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S000292970761297X"],"URL":"https:\/\/doi.org\/10.1086\/324773","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}