{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:05:44Z","timestamp":1777439144911,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4217,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1086\/338453","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T17:29:04Z","timestamp":1027704544000},"page":"51-59","source":"Crossref","is-referenced-by-count":75,"title":["Genomewide Linkage Analysis of Celiac Disease in Finnish Families"],"prefix":"10.1016","volume":"70","author":[{"given":"Jianjun","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suh-Hang","family":"Juo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4ivi","family":"Holopainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Terwilliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina","family":"Grunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Brito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi","family":"Mustalahti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markku","family":"M\u00e4ki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Conrad","family":"Gilliam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Partanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1086\/338453_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/gepi.1370110109","article-title":"LABMAN and LINKMAN: a data management system specifically designed for genome searches of complex diseases","volume":"11","author":"Adams","year":"1994","journal-title":"Genet Epidemiol"},{"key":"10.1086\/338453_bib5","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1086\/302185","article-title":"A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus","volume":"64","author":"Aita","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib6","first-page":"687","article-title":"Contribution of the MHC region to the familial risk of coeliac disease","volume":"36","author":"Bevan","year":"1999","journal-title":"J Med Genet"},{"key":"10.1086\/338453_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/S0003480098006642","article-title":"A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings","volume":"62","author":"Brett","year":"1998","journal-title":"Ann Hum Genet"},{"key":"10.1086\/338453_bib8","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1086\/302112","article-title":"Estimation of pairwise relationships in the presence of genotyping errors","volume":"63","author":"Broman","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib9","first-page":"43","article-title":"Williams-Beuren syndrome and celiac disease","volume":"47","author":"Chiaravalloti","year":"1995","journal-title":"Minerva Pediatr"},{"key":"10.1086\/338453_bib10","first-page":"252","article-title":"Faster sequential genetic linkage computations","volume":"53","author":"Cottingham","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib11","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/jmg.30.10.857","article-title":"Disease gene mapping in isolated human populations: the example of Finland","volume":"30","author":"de la Chapelle","year":"1993","journal-title":"J Med Genet"},{"key":"10.1086\/338453_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/77091","article-title":"The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes","volume":"25","author":"Eaves","year":"2000","journal-title":"Nat Genet"},{"key":"10.1086\/338453_bib13","series-title":"The genetics of coeliac disease","first-page":"197","article-title":"Coeliac disease: previous family studies","author":"Ellis","year":"1981"},{"key":"10.1086\/338453_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1101\/gr.7.2.165","article-title":"Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers: FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group","volume":"7","author":"Ghosh","year":"1997","journal-title":"Genome Res"},{"key":"10.1086\/338453_bib15","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1086\/302846","article-title":"Linkage analysis in the presence of errors III: marker loci and their map as nuisance parameters","volume":"66","author":"G\u00f6ring","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib16","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1086\/302845","article-title":"Linkage analysis in the presence of errors IV: joint pseudomarker analysis of linkage and\/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified","volume":"66","author":"G\u00f6ring","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1469-1809.2001.6510035.x","article-title":"Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease families","volume":"65","author":"Greco","year":"2001","journal-title":"Ann Hum Genet"},{"key":"10.1086\/338453_bib18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1086\/301754","article-title":"Genome search in celiac disease","volume":"62","author":"Greco","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib19","doi-asserted-by":"crossref","unstructured":"Greco L, Romino R, Coto I, Cosmo ND, Percopo S, Maglio M, Paparo F, Gasperi V, Limongelli MG, Cotichini R, D'Agate C, Tinto N, Sacchetti L, Tosi R, Stazi MA. The first large population-based twin study of coeliac disease. Gut (in press).","DOI":"10.1136\/gut.50.5.624"},{"key":"10.1086\/338453_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000022911","article-title":"Search for coeliac disease susceptibility loci on 7q11.23 candidate region: absence of association with the ELN17 microsatellite marker","volume":"50","author":"Grillo","year":"2000","journal-title":"Hum Hered"},{"key":"10.1086\/338453_bib21","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1046\/j.1523-1747.2000.00172.x","article-title":"Concordance of dermatitis herpetiformis and celiac disease in monozygous twins","volume":"115","author":"Hervonen","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1086\/338453_bib22","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1034\/j.1399-0039.1999.530503.x","article-title":"CD28\/CTLA4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease: a linkage and family-based association study","volume":"53","author":"Holopainen","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1086\/338453_bib23","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1136\/gut.48.5.696","article-title":"Candidate gene regions and genetic heterogeneity in gluten sensitivity","volume":"48","author":"Holopainen","year":"2001","journal-title":"Gut"},{"key":"10.1086\/338453_bib24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/hmg\/6.8.1335","article-title":"Linkage analysis of candidate regions for coeliac disease genes","volume":"6","author":"Houlston","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1086\/338453_bib25","doi-asserted-by":"crossref","unstructured":"Karell K, Holopainen P, Mustalahti K, Collin P, M\u00e4ki M, Partanen J. Not all HLA DR3 DQ2 haplotypes confer equal susceptibility to coeliac disease: transmission analysis in families. Scand J Gastroenterol (in press).","DOI":"10.1080\/003655202753387365"},{"key":"10.1086\/338453_bib26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1469-1809.2000.6460479.x","article-title":"A genome-wide family-based linkage study of coeliac disease","volume":"64","author":"King","year":"2000","journal-title":"Ann Hum Genet"},{"key":"10.1086\/338453_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/ng1297-435","article-title":"Demographic history and linkage disequilibrium in human populations","volume":"17","author":"Laan","year":"1997","journal-title":"Nat Genet"},{"key":"10.1086\/338453_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1034\/j.1399-0039.1999.540207.x","article-title":"A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease","volume":"54","author":"Lie","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1086\/338453_bib29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ajmg.1195","article-title":"A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22","volume":"105","author":"Liu","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1086\/338453_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1086\/321980","article-title":"A genomewide screen for autism susceptibility loci","volume":"69","author":"Liu","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib31","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/S0140-6736(96)70237-4","article-title":"Coeliac disease","volume":"349","author":"M\u00e4ki","year":"1997","journal-title":"Lancet"},{"key":"10.1086\/338453_bib32","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/0140-6736(91)92234-S","article-title":"Serological markers and HLA genes among healthy first-degree relatives of patients with coeliac disease","volume":"338","author":"M\u00e4ki","year":"1991","journal-title":"Lancet"},{"key":"10.1086\/338453_bib33","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/gut.24.6.532","article-title":"HLA-DR phenotypes in Spanish coeliac children: their contribution to the understanding of the genetics of the disease","volume":"24","author":"Mearin","year":"1983","journal-title":"Gut"},{"key":"10.1086\/338453_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/00365529850172052","article-title":"Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors","volume":"33","author":"Not","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1086\/338453_bib35","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: a program for identification of genotype incompatibilities in linkage analysis","volume":"63","author":"O'Connell","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib36","first-page":"577","article-title":"Williams-Beuren syndrome in combination with celiac disease","volume":"141","author":"Pankau","year":"1993","journal-title":"Monatsschr Kinderheilkd"},{"key":"10.1086\/338453_bib37","unstructured":"Papadatou B, Digilio C, Ferretti F, Colistro F, Bella S, Orru M, Castro M, Giannotti A (1996) Celiac disease in Williams' syndrome. Paper presented at 7th International Symposium on Coeliac Disease. Tampere, September 5\u20137."},{"key":"10.1086\/338453_bib38","series-title":"HLA 1997","first-page":"214","article-title":"Caucasian Finnish normal","author":"Partanen","year":"1997"},{"key":"10.1086\/338453_bib39","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1093\/hmg\/8.10.1913","article-title":"Molecular genetics of the Finnish disease heritage","volume":"8","author":"Peltonen","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/338453_bib40","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0003480097006258","article-title":"Genetic contribution of the HLA region to the familial clustering of coeliac disease","volume":"61","author":"Petronzelli","year":"1997","journal-title":"Ann Hum Genet"},{"key":"10.1086\/338453_bib41","first-page":"iv","article-title":"Williams syndrome and coeliac disease","volume":"82","author":"Pittschieler","year":"1993","journal-title":"Acta Paediatr"},{"key":"10.1086\/338453_bib42","series-title":"The genetics of coeliac disease","first-page":"211","article-title":"Gluten sensitive enteropathy in Spain: genetic and environmental factors","author":"Polanco","year":"1981"},{"key":"10.1086\/338453_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0198-8859(98)00008-1","article-title":"HLA-DQ2-negative celiac disease in Finland and Spain","volume":"59","author":"Polvi","year":"1998","journal-title":"Hum Immunol"},{"key":"10.1086\/338453_bib44","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0794-390","article-title":"Chromosome-specific microsatellite sets for fluorescence-based, semi- automated genome mapping","volume":"7","author":"Reed","year":"1994","journal-title":"Nat Genet"},{"key":"10.1086\/338453_bib45","first-page":"1","article-title":"Assessing the role of HLA-linked and unlinked determinants of disease","volume":"40","author":"Risch","year":"1987","journal-title":"Am J Hum Genet"},{"key":"10.1086\/338453_bib46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1399-0004.1984.tb01100.x","article-title":"Measuring the genetic contribution of a single locus to a multilocus disease","volume":"26","author":"Rotter","year":"1984","journal-title":"Clin Genet"},{"key":"10.1086\/338453_bib47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.immunol.18.1.53","article-title":"Molecular basis of celiac disease","volume":"18","author":"Sollid","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1086\/338453_bib48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0198-8859(92)90104-U","article-title":"HLA-DR and -DQ genotypes of celiac disease patients serologically typed to be non-DR3 or non-DR5\/7","volume":"35","author":"Spurkland","year":"1992","journal-title":"Hum Immunol"},{"key":"10.1086\/338453_bib49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0198-8859(90)90111-2","article-title":"Susceptibility to develop celiac disease is primarily associated with HLA-DQ alleles","volume":"29","author":"Spurkland","year":"1990","journal-title":"Hum Immunol"},{"key":"10.1086\/338453_bib50","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1034\/j.1399-0039.2000.560407.x","article-title":"The CTLA4\/CD28 gene region on chromosome 2q33 confers susceptibility to celiac disease in a way possibly distinct from that of type 1 diabetes and other chronic inflammatory disorders","volume":"56","author":"Torinsson Naluai","year":"2000","journal-title":"Tissue Antigens"},{"key":"10.1086\/338453_bib51","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng1196-329","article-title":"An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland","volume":"14","author":"Zhong","year":"1996","journal-title":"Nat Genet"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707612828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707612828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:52:30Z","timestamp":1555005150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707612828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0002929707612828"],"URL":"https:\/\/doi.org\/10.1086\/338453","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}