{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:23:50Z","timestamp":1789914230977,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":4127,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1086\/339518","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T17:03:18Z","timestamp":1033405398000},"page":"1015-1022","source":"Crossref","is-referenced-by-count":75,"title":["Premature Chromosome Condensation in Humans Associated with Microcephaly and Mental Retardation: A Novel Autosomal Recessive Condition"],"prefix":"10.1016","volume":"70","author":[{"given":"Heidemarie","family":"Neitzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luitgard M.","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlev","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wirges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"T\u00f6nnies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Trimborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Krebsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyk","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/339518_bib2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.147.2.295","article-title":"Human cyclin A is required for mitosis until mid prophase","volume":"147","author":"Furuno","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1086\/339518_bib3","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1242\/jcs.110.17.2129","article-title":"Nuclear envelope breakdown in mammalian cells involves stepwise lamina disassembly and microtubule-drive deformation of the nuclear membrane","volume":"110","author":"Georgatos","year":"1997","journal-title":"J Cell Sci"},{"key":"10.1086\/339518_bib4","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/sj.onc.1204177","article-title":"Cdc25-dependent activation of cyclin A\/cdk2 is blocked in G2 phase arrested cells independently of ATM\/ATR","volume":"20","author":"Goldstone","year":"2001","journal-title":"Oncogene"},{"key":"10.1086\/339518_bib5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0960-9822(99)80308-X","article-title":"Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal","volume":"9","author":"Hagting","year":"1999","journal-title":"Curr Biol"},{"key":"10.1086\/339518_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/226717a0","article-title":"Mammalian cell fusion: induction of premature chromosome condensation in interphase nuclei","volume":"226","author":"Johnson","year":"1970","journal-title":"Nature"},{"key":"10.1086\/339518_bib7","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/MCB.6.6.2027","article-title":"Molecular cloning of a human gene that regulates chromosome condensation and is essential for cell proliferation","volume":"6","author":"Kai","year":"1986","journal-title":"Mol Cell Biol"},{"key":"10.1086\/339518_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.146.3.573","article-title":"Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis","volume":"146","author":"Karlsson","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1086\/339518_bib9","first-page":"6","article-title":"Cell cycle analysis via BrdU-Hoechst flow cytometry\u2014principles and applications","volume":"vol 2","author":"Kubbies","year":"1989"},{"key":"10.1086\/339518_bib10","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ajmg.1320120103","article-title":"Studies of microcephalic primordial dwarfism. I: Approach to a delineation of the Seckel syndrome","volume":"12","author":"Majewski","year":"1982","journal-title":"Am J Med Genet"},{"key":"10.1086\/339518_bib11","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.292.5521.1540","article-title":"Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B","volume":"292","author":"Nemergut","year":"2001","journal-title":"Science"},{"key":"10.1086\/339518_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0962-8924(00)01773-6","article-title":"The G2-phase DNA-damage checkpoint","volume":"10","author":"O'Connell","year":"2000","journal-title":"Trends Cell Biol"},{"key":"10.1086\/339518_bib13","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0955-0674(99)80036-2","article-title":"Regulating the onset of mitosis","volume":"11","author":"Ohi","year":"1999","journal-title":"Curr Opin Cell Biol"},{"key":"10.1086\/339518_bib14","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1038\/35050676","article-title":"Re-staging mitosis: a contemporary view of mitotic progression","volume":"3","author":"Pines","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1086\/339518_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/32204","article-title":"The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller","volume":"392","author":"Renault","year":"1998","journal-title":"Nature"},{"key":"10.1086\/339518_bib16","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1083\/jcb.142.4.1013","article-title":"Entry into mitosis in vertebrate somatic cells is guarded by a chromosome damage checkpoint that reverses the cell cycle when triggered during early but not late prophase","volume":"142","author":"Rieder","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1086\/339518_bib17","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/BF01959085","article-title":"Simultaneous measurement, using flow cytometry, of radiosensitivity and defective mitogen response in ataxia telangiectasia and related syndromes","volume":"151","author":"Seyschab","year":"1992","journal-title":"Eur J Pediatr"},{"key":"10.1086\/339518_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF00216146","article-title":"G2 phase cell cycle disturbance as a manifestation of genetic cell damage","volume":"92","author":"Seyschab","year":"1993","journal-title":"Hum Genet"},{"key":"10.1086\/339518_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s004390051005","article-title":"Incidence of mosaic cell lines in vivo and malsegregation of chromosome 21 in lymphocytes in vitro of trisomy 21 patients: detection by fluorescence in situ hybridization on binucleated lymphocytes","volume":"106","author":"Shi","year":"2000","journal-title":"Hum Genet"},{"key":"10.1086\/339518_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4781(01)00204-4","article-title":"Checking out the G(2)\/M transition","volume":"1519","author":"Smits","year":"2001","journal-title":"Biochim Biophys Acta"},{"key":"10.1086\/339518_bib21","first-page":"235","article-title":"The phenomenon of premature chromosome condensation: its application to basic and applied research","volume":"23","author":"Sperling","year":"1974","journal-title":"Humangenetik"},{"key":"10.1086\/339518_bib22","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0955-0674(00)00149-6","article-title":"Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C","volume":"12","author":"Takizawa","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"10.1086\/339518_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01247331","article-title":"Chromosomal breakage, endomitosis, endoreduplication, and hypersensitivity toward radiomimetric and alkylating agents: a possible new autosomal recessive mutation in a girl with craniosynostosis and microcephaly","volume":"92","author":"Tommerup","year":"1993","journal-title":"Hum Genet"},{"key":"10.1086\/339518_bib24","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/MCB.10.2.577","article-title":"Premature chromosome condensation is induced by a point mutation in the hamster RCC1 gene","volume":"10","author":"Uchida","year":"1990","journal-title":"Mol Cell Biol"},{"key":"10.1086\/339518_bib25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0014-4827(81)90450-X","article-title":"Maturing Xenopus oocytes induce chromosome condensation in somatic plant nuclei","volume":"134","author":"von der Haar","year":"1981","journal-title":"Exp Cell Res"},{"key":"10.1086\/339518_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/mutage\/9.3.225","article-title":"Simultaneous detection of X-chromosome loss and non-disjunction in cytokinesis-blocked human lymphocytes by in situ hybridization with a centromeric DNA probe: implications for the human lymphocyte in vitro micronucleus assay using cytochalasin B","volume":"9","author":"Zijno","year":"1994","journal-title":"Mutagenesis"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707603097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707603097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T07:39:35Z","timestamp":1622187575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707603097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0002929707603097"],"URL":"https:\/\/doi.org\/10.1086\/339518","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}