{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:11:54Z","timestamp":1791040314012,"version":"4.1.0"},"reference-count":8,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":3609,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1086\/378100","type":"journal-article","created":{"date-parts":[[2003,8,21]],"date-time":"2003-08-21T12:52:44Z","timestamp":1061470364000},"page":"652-655","source":"Crossref","is-referenced-by-count":123,"title":["A Full-Likelihood Method for the Evaluation of Causality of Sequence Variants from Family Data"],"prefix":"10.1016","volume":"73","author":[{"given":"Deborah","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F.","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Goldgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/378100_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/(SICI)1098-2272(1996)13:6<595::AID-GEPI5>3.0.CO;2-#","article-title":"BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype","volume":"13","author":"Barker","year":"1996","journal-title":"Genet Epidemiol"},{"key":"10.1086\/378100_bib2","first-page":"678","article-title":"Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families","volume":"52","author":"Easton","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1086\/378100_bib3","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1200\/JCO.20.6.1480","article-title":"Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals","volume":"20","author":"Frank","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1086\/378100_bib4","series-title":"PAP: Pedigree Analysis Package, version 5.0","author":"Hasstedt","year":"2002"},{"key":"10.1086\/378100_bib5","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/gepi.1370050611","article-title":"Programs for pedigree analysis: MENDEL, FISHER, dGENE","volume":"5","author":"Lange","year":"1988","journal-title":"Genet Epidemiol"},{"key":"10.1086\/378100_bib6","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1073\/pnas.81.11.3443","article-title":"Strategies for multilocus linkage analysis in humans","volume":"81","author":"Lathrop","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/378100_bib7","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1038\/sj.onc.1204485","article-title":"Nine novel conserved motifs in BRCA1 identified by the chicken orthologue","volume":"20","author":"Orelli","year":"2001","journal-title":"Oncogene"},{"key":"10.1086\/378100_bib8","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1086\/301871","article-title":"Missense mutations in disease genes: a Bayesian approach to evaluate causality","volume":"62","author":"Petersen","year":"1998","journal-title":"Am J Hum Genet"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970762028X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970762028X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T08:52:13Z","timestamp":1551084733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292970762028X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S000292970762028X"],"URL":"https:\/\/doi.org\/10.1086\/378100","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}