{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:29:21Z","timestamp":1762079361115,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":3396,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1086\/383095","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T12:20:57Z","timestamp":1079526057000},"page":"647-660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Novel Analytical Methods Applied to Type 1 Diabetes Genome-Scan Data"],"prefix":"10.1016","volume":"74","author":[{"given":"Flemming","family":"Pociot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan E.","family":"Karlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus B.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Aalund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"Nerup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1086\/383095_bib3","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1086\/324069","article-title":"Genomewide scans of complex diseases: true linkage is hard to find","volume":"69","author":"Altm\u00fcller","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/383095_bib4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/70466","article-title":"Thinking postgenomics","volume":"23","author":"Anonymous","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/4478","article-title":"Gene expression informatics: it\u2019s all in your mine","volume":"21","author":"Bassett","year":"1999","journal-title":"Nat Genet"},{"issue":"Suppl 17","key":"10.1086\/383095_bib6","first-page":"S503","article-title":"Analysis of complex traits using neural networks","author":"Bhat","year":"1999","journal-title":"Genet Epidemiol"},{"year":"1995","series-title":"Neural networks for pattern recognition","author":"Bishop","key":"10.1086\/383095_bib7"},{"key":"10.1086\/383095_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<959::AID-GEPI66>3.0.CO;2-K","article-title":"Multipoint oligogenic linkage analysis of quantitative traits","volume":"14","author":"Blangero","year":"1997","journal-title":"Genet Epidemiol"},{"key":"10.1086\/383095_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1287\/ijoc.11.3.217","article-title":"Mathematical programming for data mining: formulations and challenges","volume":"11","author":"Bradley","year":"1999","journal-title":"INFORMS J Comput"},{"year":"1984","series-title":"Classification and regression trees","author":"Breiman","key":"10.1086\/383095_bib10"},{"key":"10.1086\/383095_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000154415","article-title":"Linkage analyses in type-I diabetes-mellitus using Caspar, a software and statistical program for conditional analysis of polygenic diseases","volume":"47","author":"Buhler","year":"1997","journal-title":"Hum Hered"},{"key":"10.1086\/383095_bib12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/985","article-title":"A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes-mellitus","volume":"19","author":"Concannon","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/6002","article-title":"Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans","volume":"21","author":"Cox","year":"1999","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1086\/323501","article-title":"Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families","volume":"69","author":"Cox","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/383095_bib15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1469-1809.2001.6510095.x","article-title":"Use of an artificial neural network to detect association between a disease and multiple marker genotypes","volume":"65","author":"Curtis","year":"2001","journal-title":"Ann Hum Genet"},{"key":"10.1086\/383095_bib16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/371130a0","article-title":"A genome-wide search for human susceptibility genes","volume":"371","author":"Davies","year":"1994","journal-title":"Nature"},{"key":"10.1086\/383095_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/genetics\/140.2.843","article-title":"Statistical-methods for linkage analysis of complex traits from high-resolution maps of identity by descent","volume":"140","author":"Dupuis","year":"1995","journal-title":"Genetics"},{"key":"10.1086\/383095_bib18","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1086\/324341","article-title":"A genomewide scan for type 1\u2013diabetes susceptibility genes in Scandinavian families: identification of new loci with evidence of interactions","volume":"69","author":"European Consortium for IDDM Genome Studies (ECIGS)","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/383095_bib19","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/(SICI)1098-2272(1997)14:2<103::AID-GEPI1>3.0.CO;2-8","article-title":"Affected sibpair linkage tests for multiple linked susceptibility genes","volume":"14","author":"Farrall","year":"1997","journal-title":"Genet Epidemiol"},{"issue":"Suppl 21","key":"10.1086\/383095_bib20","first-page":"S390","article-title":"Preliminary implementation of new data mining techniques for the analysis of simulation data from Genetic Analysis Workshop 12: problem 2","author":"Flodman","year":"2001","journal-title":"Genet Epidemiol"},{"key":"10.1086\/383095_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/371161a0","article-title":"Genetic mapping of a susceptibility locus for insulin-dependent mellitus on chromosome 11q","volume":"371","author":"Hashimoto","year":"1994","journal-title":"Nature"},{"key":"10.1086\/383095_bib22","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.2337\/diacare.23.10.1516","article-title":"Incidence of childhood type 1 diabetes worldwide","volume":"23","author":"Karvonen","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1086\/383095_bib23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1161\/01.CIR.0000024410.15081.FD","article-title":"Use of the logical analysis of data method for assessing long-term mortality risk after exercise electrocardiography","volume":"106","author":"Lauer","year":"2002","journal-title":"Circulation"},{"key":"10.1086\/383095_bib24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/881","article-title":"Sometimes it\u2019s hot, sometimes it\u2019s not","volume":"19","author":"Lernmark","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000022816","article-title":"Multi-locus nonparametric linkage analysis of complex trait loci with neural networks","volume":"48","author":"Lucek","year":"1998","journal-title":"Hum Hered"},{"key":"10.1086\/383095_bib26","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/(SICI)1098-2272(1997)14:6<1101::AID-GEPI90>3.0.CO;2-K","article-title":"Neural network analysis of complex traits","volume":"14","author":"Lucek","year":"1997","journal-title":"Genet Epidemiol"},{"key":"10.1086\/383095_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000053338","article-title":"The complexity of linkage analysis with neural networks","volume":"51","author":"Marinov","year":"2001","journal-title":"Hum Hered"},{"key":"10.1086\/383095_bib28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1137\/0111030","article-title":"An algorithm for least squares estimation of nonlinear parameters","volume":"11","author":"Marquardt","year":"1963","journal-title":"J Soc Indust Appl Mathem"},{"key":"10.1086\/383095_bib29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/991","article-title":"A search for type-1 diabetes susceptibility genes in families from the United Kingdom","volume":"19","author":"Mein","year":"1998","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1101\/gr.172901","article-title":"A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation","volume":"11","author":"Nelson","year":"2001","journal-title":"Genome Res"},{"key":"10.1086\/383095_bib31","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s001250051309","article-title":"Worldwide increase in incidence of type I diabetes: the analysis of the data on published incidence trends","volume":"42","author":"Onkamo","year":"1999","journal-title":"Diabetologia"},{"key":"10.1086\/383095_bib32","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng895","article-title":"Association of genes to genetically inherited diseases using data mining","volume":"31","author":"Perez-Iratxeta","year":"2002","journal-title":"Nat Genet"},{"key":"10.1086\/383095_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.gene.6363875","article-title":"Genetics of type 1 diabetes","volume":"3","author":"Pociot","year":"2002","journal-title":"Genes Immun"},{"key":"10.1086\/383095_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/08916939408995692","article-title":"Genetic susceptibility markers in Danish patients with type 1 (insulin-dependent) diabetes: evidence for polygenecity in man","volume":"19","author":"Pociot","year":"1994","journal-title":"Autoimmunity"},{"year":"1992","series-title":"Programs for machine learning","author":"Quinlan","key":"10.1086\/383095_bib35"},{"key":"10.1086\/383095_bib36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1086\/321276","article-title":"Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer","volume":"69","author":"Ritchie","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/383095_bib37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1471-2105-4-28","article-title":"Optimization of neural network architecture using genetic programming improves detection and modeling of gene-gene interactions in studies of human diseases","volume":"4","author":"Ritchie","year":"2003","journal-title":"BMC Bioinformatics"},{"year":"1949","series-title":"A mathematical theory of communication","author":"Shannon","key":"10.1086\/383095_bib38"},{"key":"10.1086\/383095_bib39","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.2337\/diacare.25.12.2197","article-title":"Increased risk of childhood type 1 diabetes in children born after 1985","volume":"25","author":"Svensson","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1086\/383095_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(01)00202-3","article-title":"Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models","volume":"15","author":"Todd","year":"2001","journal-title":"Immunity"},{"key":"10.1086\/383095_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1086\/302954","article-title":"Data mining applied to linkage disequilibrium mapping","volume":"67","author":"Toivonen","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/383095_bib42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-9525(00)02180-6","article-title":"HLA complex genes in type 1 diabetes and other autoimmune diseases; which genes are involved?","volume":"17","author":"Undlien","year":"2001","journal-title":"Trends Genet"},{"key":"10.1086\/383095_bib43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/sj.ejhg.5200918","article-title":"A new Web-based data mining tool for the identification of candidate genes for human genetic disorders","volume":"11","author":"van Driel","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1086\/383095_bib44","first-page":"A14","article-title":"A data-mining approach to fine-scale gene mapping","volume":"65","author":"Weir","year":"1999","journal-title":"Am J Hum Genet"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707618916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707618916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:14:00Z","timestamp":1762078440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707618916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0002929707618916"],"URL":"https:\/\/doi.org\/10.1086\/383095","relation":{},"ISSN":["0002-9297"],"issn-type":[{"type":"print","value":"0002-9297"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Analytical Methods Applied to Type 1 Diabetes Genome-Scan Data","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1086\/383095","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}