{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:20:15Z","timestamp":1791220815099,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":3243,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1086\/423857","type":"journal-article","created":{"date-parts":[[2004,8,3]],"date-time":"2004-08-03T19:48:22Z","timestamp":1091562502000},"page":"460-474","source":"Crossref","is-referenced-by-count":253,"title":["A Major Lung Cancer Susceptibility Locus Maps to Chromosome 6q23\u201325"],"prefix":"10.1016","volume":"75","author":[{"given":"J.E.","family":"Bailey-Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.I.","family":"Amos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Pinney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.S.","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gazdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Rothschild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Coons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Slusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kupert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Minna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/423857_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/(SICI)1098-2264(199905)25:1<60::AID-GCC9>3.0.CO;2-Y","article-title":"Identification of three commonly deleted regions on chromosome arm 6q in human pancreatic cancer","volume":"25","author":"Abe","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1086\/423857_bib3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1086\/302536","article-title":"Direct power comparisons between simple LOD scores and NPL scores for linkage analysis in complex diseases","volume":"65","author":"Abreu","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/gepi.0155","article-title":"Quantification of type I error probabilities for heterogeneity LOD scores","volume":"22","author":"Abreu","year":"2002","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib5","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib6","first-page":"535","article-title":"Robust variance-components approach for assessing genetic linkage in pedigrees","volume":"54","author":"Amos","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib7","doi-asserted-by":"crossref","first-page":"S768","DOI":"10.1002\/gepi.2001.21.s1.s768","article-title":"Variance components analysis for genetic linkage of time to onset for disease","volume":"21","author":"Amos","year":"2001","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib8","first-page":"A145","article-title":"Segregation analysis of lung cancer using class A regressive models","volume":"51","author":"Bailey-Wilson","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib9","series-title":"Biology of lung cancer: volume 122 of the lung biology in health and disease series","first-page":"53","article-title":"Genetics of lung cancer","author":"Bailey-Wilson","year":"1998"},{"key":"10.1086\/423857_bib10","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0002-9440(10)64658-5","article-title":"Putative tumor suppressor loci at 6q22 and 6q23\u2013q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors","volume":"158","author":"Barghorn","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1086\/423857_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-5231(21)01144-8","article-title":"Epidemiology and etiology of lung cancer","volume":"14","author":"Beckett","year":"1993","journal-title":"Clin Chest Med"},{"key":"10.1086\/423857_bib12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/sj.bjc.6601569","article-title":"Chromosomal analysis of non-small-cell lung cancer by multicolour fluorescent in situ hybridisation","volume":"90","author":"Berrieman","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1086\/423857_bib13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/oxfordjournals.aje.a112258","article-title":"Geographic patterns of lung cancer: industrial correlations","volume":"103","author":"Blot","year":"1976","journal-title":"Am J Epidemiol"},{"key":"10.1086\/423857_bib14","series-title":"Cancer epidemiology and prevention","first-page":"637","article-title":"Cancers of the lung and pleura","author":"Blot","year":"1996"},{"key":"10.1086\/423857_bib15","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1056\/NEJM197809212991202","article-title":"Lung cancer after employment in shipyards during World War II","volume":"299","author":"Blot","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1086\/423857_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0021-9681(80)90067-3","article-title":"Smoking and lung cancer: tests of a causal hypothesis","volume":"33","author":"Burch","year":"1980","journal-title":"J Chron Dis"},{"key":"10.1086\/423857_bib17","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/0002-9343(92)90621-H","article-title":"Smoking and cancer","volume":"93","author":"Carbone","year":"1992","journal-title":"Am J Med"},{"key":"10.1086\/423857_bib18","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1073\/pnas.0931262100","article-title":"Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25\u2013q27","volume":"100","author":"Cesari","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/423857_bib19","first-page":"15","article-title":"Segregation analysis of smoking-associated malignancies: evidence for mendelian inheritance","volume":"49","author":"Chen","year":"1991","journal-title":"Am J Hum Genet Supp"},{"key":"10.1086\/423857_bib20","first-page":"252","article-title":"Faster sequential genetic linkage computations","volume":"53","author":"Cottingham","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib21","unstructured":"Daw EW, Ma J, Amos CI, Spitz MR. Monte Carlo Markov chain oligogenic segregation analysis of lung cancer. Eur J Hum Genet (in press)"},{"key":"10.1086\/423857_bib22","first-page":"1338","article-title":"Conclusions of segregation analysis for family data generated under two-locus models","volume":"53","author":"Dizier","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib23","series-title":"The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today","author":"Doll","year":"1981"},{"key":"10.1086\/423857_bib24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/bmj.309.6959.901","article-title":"Mortality in relation to smoking: 40 years' observations on male British doctors","volume":"309","author":"Doll","year":"1994","journal-title":"BMJ"},{"key":"10.1086\/423857_bib25","unstructured":"Duffy DL (2002) SIBPAIR release 0.99.9, Herston, Queensland, Australia"},{"key":"10.1086\/423857_bib26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1086\/302181","article-title":"Further evidence for the increased power of LOD scores compared with nonparametric methods","volume":"64","author":"Durner","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib27","first-page":"8531","article-title":"Risk for smoking-related cancer among relatives of lung cancer patients","volume":"63","author":"Etzel","year":"2003","journal-title":"Cancer Res"},{"key":"10.1086\/423857_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0002-9343(75)90333-2","article-title":"Varied manifestations of a familial lymphoproliferative disorder","volume":"59","author":"Fraumeni","year":"1975","journal-title":"Am J Med"},{"key":"10.1086\/423857_bib29","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/bmj.1.5129.1090","article-title":"Smoking habits of monozygotic and dizygotic twins","volume":"1","author":"Friberg","year":"1959","journal-title":"Br Med J"},{"key":"10.1086\/423857_bib30","unstructured":"GAS (1998) Genetic Analysis System release, Oxford. Available at http:\/\/users.ox.ac.uk\/\u223cayoung\/gas.html (accessed July 20, 2004)"},{"key":"10.1086\/423857_bib31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/(SICI)1098-2272(1997)14:2<199::AID-GEPI8>3.0.CO;2-2","article-title":"Analysis of gene-smoking interaction in lung cancer","volume":"14","author":"Gauderman","year":"1997","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/path.1009","article-title":"Chromosomal imbalances of primary and metastatic lung adenocarcinomas","volume":"196","author":"Goeze","year":"2002","journal-title":"J Pathol"},{"key":"10.1086\/423857_bib33","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/00007611-197909000-00003","article-title":"Lung cancer in shipbuilding and related industries in Louisiana","volume":"72","author":"Gottlieb","year":"1979","journal-title":"South Med J"},{"key":"10.1086\/423857_bib34","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/gepi.1036","article-title":"Determining trait locus position from multipoint analysis: accuracy and power of three different statistics","volume":"21","author":"Greenberg","year":"2001","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib35","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1086\/301997","article-title":"The power to detect linkage in complex disease by means of simple LOD-score analyses","volume":"63","author":"Greenberg","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-4608(02)00620-9","article-title":"Allelic imbalance in selected chromosomal regions in ovarian cancer","volume":"139","author":"Hansen","year":"2002","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1086\/423857_bib37","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1001\/archinte.1958.00260140209031","article-title":"Differences between smokers and non-smokers","volume":"101","author":"Heath","year":"1958","journal-title":"Arch Intern Med"},{"key":"10.1086\/423857_bib38","first-page":"217","article-title":"Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study","volume":"60","author":"Hodge","year":"1997","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib39","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1086\/338923","article-title":"HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity","volume":"70","author":"Hodge","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00439-003-0968-7","article-title":"Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk","volume":"113","author":"Hwang","year":"2003","journal-title":"Hum Genet"},{"key":"10.1086\/423857_bib41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/gcc.10065","article-title":"Defining the region(s) of deletion at 6q16\u2013q22 in human prostate cancer","volume":"34","author":"Hyytinen","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1086\/423857_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3322\/canjclin.54.1.8","article-title":"Cancer statistics, 2004","volume":"54","author":"Jemal","year":"2004","journal-title":"CA Cancer J Clin"},{"key":"10.1086\/423857_bib43","first-page":"2281","article-title":"Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q","volume":"23","author":"Jensen","year":"2003","journal-title":"Anticancer Res"},{"key":"10.1086\/423857_bib44","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0090-4295(01)01598-9","article-title":"Accuracy of family history of cancer as reported by men with prostate cancer","volume":"59","author":"King","year":"2002","journal-title":"Urology"},{"key":"10.1086\/423857_bib45","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/j.1349-7006.2003.tb01516.x","article-title":"Genetic mapping of allelic loss on chromosome 6q within heterogeneous prostate carcinoma","volume":"94","author":"Konishi","year":"2003","journal-title":"Cancer Sci"},{"key":"10.1086\/423857_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat Genet"},{"key":"10.1086\/423857_bib47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0165-4608(00)00363-0","article-title":"Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization","volume":"125","author":"Luk","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1086\/423857_bib48","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1086\/302800","article-title":"Statistical tests for detection of misspecified relationships by use of genome-screen data","volume":"66","author":"McPeek","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib49","first-page":"2322","article-title":"Homozygous deletion on chromosome 9p and loss of heterozygosity on 9p, 6p, and 6q in primary human small cell lung cancer","volume":"54","author":"Merlo","year":"1994","journal-title":"Cancer Res"},{"key":"10.1086\/423857_bib50","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood.V91.9.3397","article-title":"6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas","volume":"91","author":"Merup","year":"1998","journal-title":"Blood"},{"key":"10.1086\/423857_bib51","first-page":"5449","article-title":"Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma","volume":"51","author":"Millikin","year":"1991","journal-title":"Cancer Res"},{"key":"10.1086\/423857_bib52","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.1957.72980250010016","article-title":"Drug reactions enzymes, and biochemical genetics","volume":"165","author":"Motulsky","year":"1957","journal-title":"JAMA"},{"key":"10.1086\/423857_bib53","first-page":"1601","article-title":"Loss of heterozygosity on the long arm of chromosome 6 in breast cancer: possibly four regions of deletion","volume":"2","author":"Noviello","year":"1996","journal-title":"Clin Cancer Res"},{"key":"10.1086\/423857_bib54","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: a program for identifying marker typing incompatibilities in linkage analysis","volume":"63","author":"O'Connell","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib55","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1073\/pnas.86.11.4175","article-title":"Computer-simulation methods in human linkage analysis","volume":"86","author":"Ott","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/423857_bib56","series-title":"Analysis of human linkage","author":"Ott","year":"1999"},{"key":"10.1086\/423857_bib57","unstructured":"Pankratz VS, de Andrade M, Therneau T. The random effects Cox proportional hazards model: variance components for time to onset model. Genet Epidemiol (in press)"},{"key":"10.1086\/423857_bib58","first-page":"2331","article-title":"Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lung","volume":"57","author":"Petersen","year":"1997","journal-title":"Cancer Res"},{"key":"10.1086\/423857_bib59","first-page":"2606","article-title":"Allelic losses on chromosome 6q25 in Hodgkin and Reed Sternberg cells","volume":"63","author":"Re","year":"2003","journal-title":"Cancer Res"},{"key":"10.1086\/423857_bib60","series-title":"SEER Cancer Statistics Review, 1973\u20131997","author":"Ries","year":"2000"},{"key":"10.1086\/423857_bib61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000154047","article-title":"Model misspecification and multipoint linkage analysis","volume":"42","author":"Risch","year":"1992","journal-title":"Hum Hered"},{"key":"10.1086\/423857_bib62","series-title":"Statistical Analysis for Genetic Epidemiology [computer program package]","author":"S.A.G.E.","year":"2002"},{"key":"10.1086\/423857_bib63","series-title":"Occupational lung diseases","first-page":"657","article-title":"Occupational pulmonary neoplasms","author":"Seaton","year":"1984"},{"key":"10.1086\/423857_bib64","series-title":"Lung cancer","first-page":"57","article-title":"Familial predisposition to lung cancer","author":"Sellers","year":"1998"},{"key":"10.1086\/423857_bib65","series-title":"Origins of human cancer: a comprehensive review","first-page":"775","article-title":"Evidence for Mendelian factors in early onset lung cancer","author":"Sellers","year":"1991"},{"key":"10.1086\/423857_bib66","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/jnci\/82.15.1272","article-title":"Evidence for Mendelian inheritance in the pathogenesis of lung cancer","volume":"82","author":"Sellers","year":"1990","journal-title":"J Nat Cancer Inst"},{"key":"10.1086\/423857_bib67","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/gepi.1370090405","article-title":"The effect of cohort differences in smoking prevalence on models of lung cancer susceptibility","volume":"9","author":"Sellers","year":"1992","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib68","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/aje\/126.2.237","article-title":"Increased familial risk for non-lung cancer among relatives of lung cancer patients","volume":"126","author":"Sellers","year":"1987","journal-title":"Am J Epidemiol"},{"key":"10.1086\/423857_bib69","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1086\/339370","article-title":"Individual specific liability groups in genetic linkage analysis with application to Li-Fraumeni syndrome","volume":"70","author":"Shete","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib70","first-page":"1323","article-title":"Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker sharing statistics","volume":"58","author":"Sobel","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000053366","article-title":"Multipoint estimation of identity-by-descent probabilities at arbitrary positions among marker loci on general pedigrees","volume":"52","author":"Sobel","year":"2001","journal-title":"Hum Hered"},{"key":"10.1086\/423857_bib72","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/(SICI)1097-0215(19990621)84:3<331::AID-IJC23>3.0.CO;2-J","article-title":"Allelic loss on chromosome 6q in primary prostate cancer","volume":"84","author":"Srikantan","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1086\/423857_bib73","series-title":"Handbook of genetic linkage","author":"Terwilliger","year":"1994"},{"key":"10.1086\/423857_bib74","series-title":"Mixed-effect Cox models: sparse matrices, and their use in correlated frailty","author":"Therneau","year":"2003"},{"key":"10.1086\/423857_bib75","first-page":"1422","article-title":"A large 6q deletion is a common cytogenetic alteration in fibroadenomas, pre-malignant lesions and carcinomas of the breast","volume":"6","author":"Tibiletti","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1086\/423857_bib76","first-page":"289","article-title":"Familial aggregation of lung cancer in humans","volume":"30","author":"Tokuhata","year":"1963","journal-title":"J Nat Cancer Inst"},{"key":"10.1086\/423857_bib77","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/hed.10391","article-title":"Use of single nucleotide polymorphism arrays to identify a novel region of loss on chromosome 6q in squamous cell carcinomas of the oral cavity","volume":"26","author":"Tong","year":"2004","journal-title":"Head Neck"},{"key":"10.1086\/423857_bib78","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1349-7006.2000.tb00944.x","article-title":"Mapping of target regions of allelic loss in primary breast cancers to 1-cM intervals on genomic contigs at 6q21 and 6q25.3","volume":"91","author":"Utada","year":"2000","journal-title":"Jpn J Cancer Res"},{"key":"10.1086\/423857_bib79","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/ijc.10677","article-title":"Deletion of chromosomal region 6q14\u201316 in prostate cancer","volume":"102","author":"Verhagen","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1086\/423857_bib80","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000048601","article-title":"HLODs, trait models and ascertainment: implications of admixture for parameter estimation and linkage detection","volume":"53","author":"Vieland","year":"2002","journal-title":"Hum Hered"},{"key":"10.1086\/423857_bib81","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2","article-title":"Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer types","volume":"21","author":"Virmani","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1086\/423857_bib82","first-page":"A204","article-title":"SLINK: a general simulation program for linkage analysis","volume":"47","author":"Weeks","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib83","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1001\/jama.283.22.2975","article-title":"Are increasing 5-year survival rates evidence of success against cancer?","volume":"283","author":"Welch","year":"2000","journal-title":"JAMA"},{"key":"10.1086\/423857_bib84","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1086\/318186","article-title":"Problems in the definition, interpretation, and evaluation of genetic heterogeneity","volume":"68","author":"Whittemore","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib85","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/302570","article-title":"Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results","volume":"65","author":"Williams","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1086\/423857_bib86","series-title":"Sample preparation from paraffin-embedded tissues","first-page":"153","article-title":"PCR protocols","author":"Wright","year":"1990"},{"key":"10.1086\/423857_bib87","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/(SICI)1098-2272(199911)17:4<253::AID-GEPI2>3.0.CO;2-K","article-title":"Lung cancer risk in families of nonsmoking probands: heterogeneity by age at diagnosis","volume":"17","author":"Yang","year":"1999","journal-title":"Genet Epidemiol"},{"key":"10.1086\/423857_bib88","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1038\/sj.onc.1206474","article-title":"SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer","volume":"22","author":"Zeller","year":"2003","journal-title":"Oncogene"},{"key":"10.1086\/423857_bib89","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/(SICI)1098-2264(200001)27:1<52::AID-GCC7>3.0.CO;2-X","article-title":"A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by florescence in situ hybridization","volume":"27","author":"Zhang","year":"2000","journal-title":"Genes Chromosomes Cancer"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707633175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707633175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T19:13:33Z","timestamp":1624562013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707633175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0002929707633175"],"URL":"https:\/\/doi.org\/10.1086\/423857","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}